Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for jointly training an image embedding model and a text embedding model. In one aspect, a method comprises: processing data from a historical query log of a search system to generate a candidate set of training examples, wherein each training example comprises: (i) a search query comprising a sequence of one or more words, (ii) an image, and (iii) selection data characterizing how often users selected the image in response to the image being identified by a search result for the search query; selecting a plurality of training examples from the candidate set of training examples; and using the training data to jointly train the image embedding model and the text embedding model.

Abstract: An energy-reclamation apparatus of the present invention including at least a supercapacitor element connected with a charging source and a controlled circuit. After the supercapacitor element is charged to the potential of the charging source, the supercapacitor element and the charging source will work in series to conduct a repetitive polarity reversal of the supercapacitor element through a controlled circuit. As the supercapacitor element discharges, it is reversely charged concurrently. In other words, while the voltage of the supercapacitor element is decreasing on the side, a negative potential is complementarily developing on the other side. By repeatedly reversing the polarity of the supercapacitor element, more energy from the serially connected charging source can be reclaimed and reused.