Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: An electrooculography (EOG) signal capture system comprises a) a sensor array adapted for being located at one of a left or right ears of a user and/or for fully or partially being implanted in the head at left or right ears of a user, the sensor array comprising a number Ns of electric potential sensors, respectively, for sensing respective electric potentials from the user's head, where Ns is larger than or equal to two, b) electronic circuitry coupled to the sensor array and configured to provide at least two different beamformed signals (SBF1, SBF2), each being representative of a weighted combination of said electric potentials, or of signals derived therefrom, and wherein a difference between said at least two different beamformed signals (?PBF=SBF1?SBF2)—at least in a specific electrooculography mode of operation—represents an electrooculography signal (?PEOG) from one or both eyes of said user. A single-sensor EOG-system is further proposed. The invention may e.g.

Abstract: To protect corporate information technology (IT) networks, corporations or organizations can design their networks with secure technology. For example, before an employee can remotely access his or her company's network via a user device, a server associated with the company's network can setup an exemplary secure digital certificate for the user device. The secure digital certificate includes a public Internet Protocol (IP) address associated with a router used by the user device to access the Internet. When employee attempts to remotely access his or her company's network, the user device or a router associated with the user device can send the secure digital certificate along with a current public IP address of the router used by the user device to access the Internet. In some embodiments, if the public IP address included in the digital certificate matches the current public IP address, the user device can access the company's network.

Abstract: A conditions monitoring system may include a system controller. The controller may include a device processor and a non-transitory computer readable medium. The computer readable medium may include instructions executable by the device processor to perform the following steps: receiving positional data from a plurality of wearable devices of a plurality of associated wearers; making a determination of a possible dangerous environmental condition based on data received from the wearable device, including the positional data; applying one or more filters to eliminate false positive determinations of possible dangerous conditions; and providing instructions, based on the determination of a possible dangerous environmental condition, to the wearable device for the wearer to follow.

Abstract: Various systems and methods are provided for a biased cathode assembly of an X-ray tube with improved thermal management and a method of manufacturing same. In one example, a cathode assembly of an X-ray tube comprises an emitter assembly including an emitter coupled to an emitter support structure, and an electrode assembly including an electrode stack and a plurality of bias electrodes. The emitter assembly including a plurality of independent components that are coupled together. The electrode assembly including a plurality of independent components that are coupled together, and the emitter assembly being coupled to the electrode assembly.

Abstract: The present invention relates to diaminotriazine compounds and to their use as herbicides. It also relates to agrochemical compositions for crop protection and to a method for controlling unwanted vegetation.

Abstract: A system and method for improving the download time of emails in an environment in which a server distributes emails to persons working in close proximity to each other. When these persons receive multi-recipient emails intended for several or all of these persons, the server distributing the emails delivers the multi-recipient emails to the first one of the persons who logged on to read his or her emails on his or her personal computer, for distribution to the other persons over a personal area network. This reduces the download time for the persons downloading their emails at a subsequent time.

Abstract: The present invention relates to diaminotriazine compounds and to their use as herbicides. It also relates to agrochemical compositions for crop protection and to a method for controlling unwanted vegetation.

Abstract: The present invention relates to a preferably computer-implemented method of raising a group of monogastric animals Issues such as exposure of the animals to an initiator of a disease are recognized at an early stage by ex vivo analysis of blood samples. Said analysis is done where the animals are raised using point-of-care devices. Accuracy of separation between affected and non-affected animals is increased by measuring a set of pre-determined blood parameters. The landless monogastric animal production system of the invention facilitates implementation of the method of the invention.

Abstract: A system that incorporates the subject disclosure may include, for example, a gaming system that cooperates with a graphical user interface to enable user modification and enhancement of one or more audio streams associated with the gaming system. In embodiments, the audio streams may include a game audio stream, a chat audio stream of conversation among players of a video game, and a microphone audio stream of a player of the video game. Additional embodiments are disclosed.

Abstract: According to some implementations, while a proxy routes production traffic to a first application (app) version that runs in a plurality of container orchestration system (cos) pods having first app version containers, configuration information is received including an identification of a second app version container image for a second app version. The second app version is an updated version of the first app version. Cos pods having second app version containers are brought up based on the second app version container image identified in the configuration information. Test and/or warmup traffic is caused to be routed to the second app version containers. Responsive to an indication regarding the routing of the test and/or warmup traffic to the second app version, causing a transition to sending production traffic to the second app version containers instead of to the first app version.

Abstract: The present disclosure provides liver-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in liver tissues and treat liver diseases and disorders.

Abstract: According to some implementations, while a proxy routes production traffic to a first application (app) version that runs in a plurality of container orchestration system (cos) pods having first app version containers, configuration information is received including an identification of a second app version container image for a second app version. The second app version is an updated version of the first app version. Cos pods having second app version containers are brought up based on the second app version container image identified in the configuration information. Test and/or warmup traffic is caused to be routed to the second app version containers. Responsive to an indication regarding the routing of the test and/or warmup traffic to the second app version, causing a transition to sending production traffic to the second app version containers instead of to the first app version.

Abstract: According to some implementations, while a proxy routes production traffic to a first application (app) version that runs in a plurality of container orchestration system (cos) pods having first app version containers, configuration information is received including an identification of a second app version container image for a second app version. The second app version is an updated version of the first app version. Cos pods having second app version containers are brought up based on the second app version container image identified in the configuration information. Test and/or warmup traffic is caused to be routed to the second app version containers. Responsive to an indication regarding the routing of the test and/or warmup traffic to the second app version, causing a transition to sending production traffic to the second app version containers instead of to the first app version.

Abstract: Cloud services release orchestration with a reusable deployment pipeline. According to some implementations, responsive to receiving from a COS controller parameters from configuration information provided to the COS controller while an app aware proxy routes production traffic to a first application (app) version that communicates with a database management system (DBMS) and that runs in container orchestration system (COS) pods having first app version containers, causing a validation of a second app version using COS pods having second app version containers that are now live after having been brought up by the COS controller responsive to the provision of the configuration information. After the validation, causing the transition to sending production traffic to the second app version containers that are determined to be live instead of to the first app version containers.

Abstract: A dust-proof covering element is provided to close a projection aperture located in the dashboard of a vehicle and through which the information-carrying source light beam projected by the projecting module of a head-up display device passes on its way to a partially reflective return element. The covering element comprises a transparent carrier and an optical coating placed on one of the faces of the carrier; wherein, the optical coating comprises a metal layer with plasmonic properties, said metal layer being endowed with an array of subwavelength nanoperforations, and being configured to allow the extraordinary transmission of one or more restricted bands of wavelengths of the visible spectrum that are centered on the one or more wavelengths of the light beam projected by the projecting module.

Abstract: Cloud services release orchestration with a reusable deployment pipeline. According to some implementations, responsive to receiving from a COS controller parameters from configuration information provided to the COS controller while an app aware proxy routes production traffic to a first application (app) version that communicates with a database management system (DBMS) and that runs in container orchestration system (COS) pods having first app version containers, causing a validation of a second app version using COS pods having second app version containers that are now live after having been brought up by the COS controller responsive to the provision of the configuration information. After the validation, causing the transition to sending production traffic to the second app version containers that are determined to be live instead of to the first app version containers.

Abstract: Cloud services release orchestration with a reusable deployment pipeline. According to some implementations, responsive to receiving from a COS controller parameters from configuration information provided to the COS controller while an app aware proxy routes production traffic to a first application (app) version that communicates with a database management system (DBMS) and that runs in container orchestration system (COS) pods having first app version containers, causing a validation of a second app version using COS pods having second app version containers that are now live after having been brought up by the COS controller responsive to the provision of the configuration information. After the validation, causing the transition to sending production traffic to the second app version containers that are determined to be live instead of to the first app version containers.

Abstract: A method for manufacturing a lead includes forming an elongated multi-lumen conductor guide defining a central stylet lumen and a plurality of conductor lumens arranged around the stylet lumen. The multi-lumen conductor guide is twisted to form at least one helical section where the plurality of conductor lumens each forms a helical pathway around the stylet lumen. Each of the helical pathways of the at least one helical section has a pitch that is no less than 0.04 turns per centimeter.

Abstract: A method for manufacturing a lead includes forming an elongated multi-lumen conductor guide defining a central stylet lumen and a plurality of conductor lumens arranged around the stylet lumen. The multi-lumen conductor guide is twisted to form at least one helical section where the plurality of conductor lumens each forms a helical pathway around the stylet lumen. Each of the helical pathways of the at least one helical section has a pitch that is no less than 0.04 turns per centimeter.