Abstract: Cannula and device implantation systems are provided. In some embodiments, cannula members are provided that comprise membranes to prevent and reduce infection. Cannulas of the present disclosure are operable to be provided as indwelling catheters. In some embodiments, systems of the disclosure comprise encapsulation devices for housing cells and providing various therapeutic benefits to a patient or host.

Abstract: An implant assembly and methods for loading implant devices which avoids the accidental deposition of transplanted material or other contaminates on the exterior of the device during transportation, storage, and handling are disclosed. The implant assembly of the invention may be used with a large variety of implant devices for implanting a variety of materials such as cells, tissue or other materials into a host. The implant assembly includes an implant device having an elongated port and a first chamber for holding material for implantation and a container with a second chamber for holding the implant device. The container functions to maintain the sterility and protect the physical integrity of the implant device during loading, storage, cryopreservation and transportation and is removed immediately prior to implantation of the device. The container may optionally include liquid media for cellular growth, maintenance, cryostorage, or transportation purposes.

Abstract: Methods for enhancing vascular support of cells housed within an implanted apparatus are disclosed. The methods comprise placing a population of therapeutic substance-producing cells into the cell receiving chamber of an immunoisolation apparatus, implanting the apparatus into a patient, and administering an immunomodulatory agent to the patient. The immunomodulatory agent increases the number of close vascular structures in the vicinity of the implanted device, which increases the long term survival of the cell population housed therein.