Patents by Inventor Thomas M. Woerner

Thomas M. Woerner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilization of HOunder alkaline conditions for use in luminescence, fluorescence and colorimetric assays for enhanced detection of peroxidase type assays
    Patent number: 7563566
    Abstract: The invention relates to stannous halide stabilized and/or enhanced alkaline solutions to be used in combination with calorimetric, luminescent and fluorescent assays. The buffered solutions stabilize hydrogen peroxide at a pH greater than 7.0 and preferably greater than 9.0. By stabilizing and/or enhancing hydrogen peroxide in the buffer system, the compositions used in such assays may have a higher shelf-life and provide enhanced detection of the subject analyte.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: July 21, 2009
    Assignee: SurModics, Inc.
    Inventors: Thomas M. Woerner, Joseph A. Rosebrock, Charles W. Hewitt, Heidi L. Woerner
  • Stabilization of HOunder alkaline conditions for use in luminescence, fluorescence and colorimetric assays for enhanced detection of peroxidase type assays
    Patent number: 7381797
    Abstract: The invention relates to stannous halide stabilized and/or enhanced alkaline solutions to be used in combination with colorimetric, luminescent and fluorescent assays. The buffered solutions stabilize hydrogen peroxide at a pH greater than 7.0 and preferably greater than 9.0. By stabilizing and/or enhancing hydrogen peroxide in the buffer system, the compositions used in such assays may have a higher shelf-life and provide enhanced detection of the subject analyte.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: June 3, 2008
    Assignee: SurModics, Inc.
    Inventors: Thomas M. Woerner, Joseph A. Rosebrock, Charles W. Hewitt, Heidi L. Woerner
  • Charcoal stabilization of phenyl phosphates
    Patent number: 7214481
    Abstract: The invention discloses methods, compositions and kits for stabilizing a solubilized phenyl phosphate, preferably paranitrophenyl phosphate (PNPP), using charcoal. Also disclosed are methods, compositions and kits for recycling solubilized phenyl phosphate, preferably PNPP, that has an absorbance of less than 0.1 when measured at 405 nm due to non-enzymatic hydrolysis.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: May 8, 2007
    Assignee: BioFX Laboratories, Inc.
    Inventor: Thomas M. Woerner
  • Charcoal stabilization of phenyl phosphates
    Patent number: 7001717
    Abstract: The invention discloses methods, compositions and kits for stabilizing a solubilized phenyl phosphate, preferably paranitrophenyl phosphate (PNPP), using charcoal. Also disclosed are methods, compositions and kits for recycling solubilized phenyl phosphate, preferably PNPP, that has an absorbance of less than 0.1 when measured at 405 nm due to non-enzymatic hydrolysis.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: February 21, 2006
    Assignee: BioFX Laboratories, Inc.
    Inventor: Thomas M. Woerner
  • Stabilization of H2O2 under alkaline conditions for use in luminescence, fluorescence and colorimetric assays for enhanced detection of peroxidase type assays
    Publication number: 20030073150
    Abstract: The invention relates to stannous halide stabilized and/or enhanced alkaline solutions to be used in combination with colorimetric, luminescent and fluorescent assays. The buffered solutions stabilize hydrogen peroxide at a pH greater than 7.0 and preferably greater than 9.0. By stabilizing and/or enhancing hydrogen peroxide in the buffer system, the compositions used in such assays may have a higher shelf-life and provide enhanced detection of the subject analyte.
    Type: Application
    Filed: May 9, 2002
    Publication date: April 17, 2003
    Inventors: Thomas M. Woerner, Joseph A. Rosebrock, Charles W. Hewitt, Heidi L. Woerner
  • Formazan-based immunoassay
    Patent number: 5916746
    Abstract: This invention relates to an improved method for detecting and quantifying the presence of a target molecule, such as an antigen, an antibody or a polynucleotide, in a sample which method uses alkaline phosphatase as the reporter enzyme and the reduction of a tetrazolium salt to a formazan as part of the detection/signaling system.
    Type: Grant
    Filed: May 9, 1996
    Date of Patent: June 29, 1999
    Assignee: Kirkegaard & Perry Laboratories, Inc.
    Inventors: Carrington S. Cobbs, Thomas M. Woerner