Patents by Inventor Thomas Macklin

Thomas Macklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240069026
    Abstract: A method assessing tissue morphology using machine learning includes a step of training a machine learnable device to predict the status of a diagnostic feature in stained tissue samples. The machine learnable device is trained with a characterized set of digital images of stained tissue samples. Each digital image of the characterized set has a known status for the diagnostic feature and an extracted feature map provides values for a extracted feature over an associated 2-dimensional grid of spatial locations. A step of inputting the set of extracted feature maps is inputted into the machine learnable device to form associations therein between the set of extracted feature maps to and the known status for the diagnostic feature to form a trained machine learnable device. The status for the diagnostic feature of a stained tissue sample of unknown status for the diagnostic feature is predicted from the trained machine learnable device.
    Type: Application
    Filed: November 7, 2023
    Publication date: February 29, 2024
    Applicant: University of Southern California
    Inventors: David B. AGUS, Paul Thomas MACKLIN, Rishi Raghav RAWAT, Daniel Lee RUDERMAN
  • Patent number: 11835524
    Abstract: A method assessing tissue morphology using machine learning includes a step of training a machine learnable device to predict the status of a diagnostic feature in stained tissue samples. The machine learnable device is trained with a characterized set of digital images of stained tissue samples. Each digital image of the characterized set has a known status for the diagnostic feature and an extracted feature map provides values for a extracted feature over an associated 2-dimensional grid of spatial locations. A step of inputting the set of extracted feature maps is inputted into the machine learnable device to form associations therein between the set of extracted feature maps to and the known status for the diagnostic feature to form a trained machine learnable device. The status for the diagnostic feature of a stained tissue sample of unknown status for the diagnostic feature is predicted from the trained machine learnable device.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: December 5, 2023
    Assignee: University of Southern California
    Inventors: David B. Agus, Paul Thomas Macklin, Rishi Raghav Rawat, Daniel Lee Ruderman
  • Publication number: 20200388028
    Abstract: A method assessing tissue morphology using machine learning includes a step of training a machine learnable device to predict the status of a diagnostic feature in stained tissue samples. The machine learnable device is trained with a characterized set of digital images of stained tissue samples. Each digital image of the characterized set has a known status for the diagnostic feature and an extracted feature map provides values for a extracted feature over an associated 2-dimensional grid of spatial locations. A step of inputting the set of extracted feature maps is inputted into the machine learnable device to form associations therein between the set of extracted feature maps to and the known status for the diagnostic feature to form a trained machine learnable device. The status for the diagnostic feature of a stained tissue sample of unknown status for the diagnostic feature is predicted from the trained machine learnable device.
    Type: Application
    Filed: March 6, 2018
    Publication date: December 10, 2020
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: David B. AGUS, Paul Thomas MACKLIN, Rishi Raghav RAWAT, Daniel Lee RUDERMAN
  • Publication number: 20120185911
    Abstract: A method of transferring data from a server via a web application by receiving a request from a user operating in a disparate security domain for data on a data store. Generating a labeled view of the data requested from the data store, wherein the label-data relationship can be trusted at a level commensurate to the trust level of the operating system. Next, determining if the data is authorized by a security policy with a policy design engine; and then transmitting the data to the user if the data is authorized. Data can also be transferred by receiving a data flow from the user for writing to the data store. Next, the data flow can be inspected for disallowed content, and a determination is made if the data flow is authorized. If the data flow is authorized, mediating the data flow between the user and the data store with a trusted monitor.
    Type: Application
    Filed: September 30, 2011
    Publication date: July 19, 2012
    Inventors: Khandys Polite, Thomas Macklin, John Ashmore
  • Patent number: 4070638
    Abstract: A surface acoustic wave (SAW) tapped delay line, including a piezoelectric substrate having a pair of signal launching transducers disposed thereon for providing surface acoustic waves in the substrate in response to electrical signals applied thereto, and including a plurality of transducer taps disposed in an interaction region of the substrate for providing a plurality of sensed electrical signals in response to the surface acoustic waves propagating through the interaction region, the plurality of sensed electrical signals including signals at the frequency of each of the acoustic waves, is combined with a plurality of nonlinear frequency mixers, each responsive to a corresponding one of the transducer taps, and each providing signal manifestations of the sum and difference frequency of the surface acoustic waves in a selected one of two phases which are displaced by 180.degree.
    Type: Grant
    Filed: April 14, 1976
    Date of Patent: January 24, 1978
    Assignee: United Technologies Corporation
    Inventor: Thomas Macklin Reeder
  • Patent number: 4024480
    Abstract: A surface acoustic wave (SAW) tapped delay line, including a piezoelectric substrate having a pair of signal launching transducers disposed thereon for providing surface acoustic waves in the substrate in response to electrical signals applied thereto, and including a plurality of transducer taps disposed in an interaction region of the substrate for providing a plurality of sensed electrical signals in response to the surface acoustic waves propagating through the interaction region, the plurality of sensed electrical signals including signals at the frequency of each of the acoustic waves, is combined with a plurality of nonlinear frequency mixers, each responsive to a corresponding one of the transducer taps, and each providing signal manifestations of the sum and different frequencies of the surface acoustic waves in a selected one of two phases which are displaced by 180.degree.
    Type: Grant
    Filed: April 14, 1976
    Date of Patent: May 17, 1977
    Assignee: United Technologies Corporation
    Inventors: Thomas Macklin Reeder, Thomas Walter Grudkowski