Abstract: The present invention provides isolated T cell receptors (TCRs) that specifically bind to an HLA-displayed New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1) peptides, as well as therapeutic and diagnostic methods of using those isolated TCRs.

Abstract: This invention relates to fault detection in electrical circuits. The invention provides an input module for electrically isolating an input signal received via a field sensor to be transmitted to a plurality of processors, in which the input module comprises a plurality of optical coupler/controller circuits; and each optical coupler/controller comprises a light emitting diode drive sub-circuit driving a light emitting diode; and an input sub-circuit; and in which a sensor voltage representing said input signal and a supply voltage are connected to each input sub-circuit; and each of said light emitting diode drive sub-circuits are connected in series between the supply voltage and ground.

Abstract: This invention relates to line frequency synchronisation for use in diagnostics for alternating current electrical circuits. The invention provides a method of synchronising measurement system frequency with an alternating current line frequency comprising the steps of: adjusting the frequency of the measurement system frequency using a frequency locked loop until the measurement system frequency is within a predetermined range of said alternating current line frequency; and when the measurement system frequency is within a predetermined range of said alternating current line frequency adjusting the phase and the frequency of the measurement system frequency using a phase and frequency locked loop.

Abstract: This invention relates to a method and apparatus for output current control. The invention provides an output module slice for controlling an output current comprising: an output field interface controller for controlling an input voltage to a first field effect transistor; an analogue to digital converter connected to read the current flowing through said first field effect transistor and to provide a digital signal dependent thereon to said output field interface controller.

Abstract: This invention relates to overload protection for a circuit driving a direct current (DC) load.

Abstract: This invention relates to fault detection in electrical circuits, in particular it relates to fault detection for a plurality of adjacent input circuits. The invention provides a method and apparatus for detecting a control or communication fault on an analogue circuit by digitally simulating said analogue circuit; driving the digitally simulated circuit with a control input also used to drive said analogue circuit; and comparing an output of said simulated circuit with a reference output and setting an error condition in the event that the compared outputs differ.

Abstract: This invention relates to fault detection in electrical circuits. The invention provides a switch for a fault tolerant digital output module comprising: an output transistor pair for enabling and disabling an alternating output current; and a current limiter for clamping the output current to a predetermined maximum value.

Abstract: This invention relates to fault detection in electrical circuits. The invention provides a method and apparatus for testing an input circuit by generating a periodic test signal having a predetermined phase and a predetermined amplitude; summing the test signal and an input signal to provide a summed signal; processing the summed signal to provide an output signal; generating an extracted test signal from the output signal; comparing the extracted test signal with a reference signal representing said periodic test signal; generating an error signal in dependence upon the result of said comparing step. The invention also provides a method and apparatus for testing a plurality of adjacent input circuits.

Abstract: A process for fabricating an electronic module (30) and a packaged electronic device (56) having a thermally conductive substrate includes the step of thermally spraying of a dielectric layer (12) onto a baseplate (10). An electrically conductive layer (18) is then direct bonded to the thermally sprayed dielectric layer. The thermally sprayed dielectric layer can be formed at selected locations on the upper surface of the baseplate (10) by forming a pattern on the upper surface prior to carrying out the thermal spraying process. The electrically conductive layer (18) is patterned to form an interconnect pattern overlying the baseplate. Because the thermal spraying process can form extremely thin dielectric layers, an electronic module (30) fabricated in accordance with the invention exhibits high heat transfer characteristics.

Abstract: A reproduction machine for producing copies incorporating a control for varying, infinitely over a given range copy shading. The control operates to change the fixed bias potential applied to the magnetic brush type developing rolls by providing through a variable voltage circuit, varying biasing potentials.

Abstract: A reproducing machine in which a member has successive latent images recorded thereon. The reproducing machine includes a pair of developer units. One developer unit is located in the operative position in the reproducing machine with the other unit being remote therefrom. Each developer unit contains different colored particles. Color changes are achieved by interchanging developer units to develop one latent image with particles of one color and the other latent image with particles of the other color.

Abstract: An electrostatic reproduction machine has a photoconductive member and a transfer roller in contact therewith, the roller having a texturized surface formed so as to prevent or minimize the possibility of a sheet of paper wrapping itself around the roller as the sheet is passing between the photoconductive member and the roller during the transfer operation.

Abstract: Improved stripping of a transfer member (having a developed image thereon) from a photoconductive surface of an electrostatic reproduction machine is effected by charging the lead edge of the member with a first charge, and then charging the body of the member having the developed image thereon with a second charge which is different than the first charge. The second charge has a magnitude and polarity which prevents retransfer of the developed image to the photoconductive surface.