Abstract: The present invention relates generally to single nucleotide polymorphisms (SNP) associated with increased resistance of a rainbow trout (Oncorhynchus mykiss) to infectious pancreatic necrosis (IPN). In particular, the present invention provides methods for predicting increased resistance of a rainbow trout to infectious pancreatic necrosis (IPN) and methods for selecting a rainbow trout having increased resistant to infectious pancreatic necrosis. The present invention further provides rainbow trout, rainbow trout cells and populations thereof carrying at least one allele conferring IPN resistance (“IPN resistance allele”) in their genome as well as nucleic acid molecules comprising nucleotide sequences associated with the SNPs of the present invention.

Abstract: The invention relates to a device for use in maintaining cache coherence in a multiprocessor computing system. The snoop filter device is connectable with a plurality of cache elements, where each cache element comprises a number of cache agents. The snoop filter device comprises a plurality of snoop filter storage locations, where each snoop filter storage location is mapped to one cache element.

Abstract: The present invention relates to methods of predicting resistance to heart and skeletal muscle inflammation in salmonids, the method comprising determining the alleles present at a DNA polymorphism in the salmonid and predicting whether or not the salmonid is resistant to heart and skeletal muscle inflammation based on the determination of the alleles. The invention also relates to related methods of detecting, in a sample from a salmonid, the alleles present at a DNA polymorphism associated with resistance to heart and skeletal muscle inflammation, methods for obtaining an indication of risk of a salmonid developing heart and skeletal muscle inflammation, uses of such DNA polymorphisms, and methods of detecting, in a sample from a salmonid, one or more salmonid gene variants.

Abstract: The invention relates to a device for use in maintaining cache coherence in a multiprocessor computing system. The snoop filter device is connectable with a plurality of cache elements, where each cache element comprises a number of cache agents. The snoop filter device comprises a plurality of snoop filter storage locations, where each snoop filter storage location is mapped to one cache element.

Abstract: A computer system includes a first group of CPU modules operatively coupled to at least one first Programmable ASIC Node Controller configured to execute transactions directly or through a first interconnect switch to at least one second Programmable ASIC Node Controller connected to a second group of CPU modules running a single instance of an operating system.

Abstract: A method of predicting the ability of a salmon to utilise dietary pigment, the method comprising determining the alleles present at one or more DNA polymorphism in the salmon and predicting the ability of the salmon to utilise dietary pigment based on the determination of the alleles. The method may be used for selecting a salmon for use as broodstock. Also contemplated is a method of improving the ability of a salmon to utilise dietary pigment, the method including the step of administering an agent that inhibits the expression of the genes bcmo1-like and/or bcmo1 and/or an agent that inhibits the activities of the proteins Bcmo1-like and/or Bcmo1.

Abstract: The present invention relates to cache coherent node controllers for scale-up shared memory systems. In particular it is disclosed a computer system at least comprising a first group of CPU modules connected to at least one first FPGA Node Controller configured to execute transactions directly or through a first interconnect switch to at least one second FPGA Node Controller connected to a second group of CPU modules running a single instance of an operating system.

Abstract: The Invention relates to a method of predicting resistance to infectious pancreatic necrosis in salmon, the method comprising determining the alleles present at a DNA polymorphism in the salmon and predicting whether or not the salmon is resistant to infectious pancreatic necrosis based on the determination of the alleles. The invention also relates to a method of selecting a salmon for use as broodstock, wherein the salmon is selected based on the prediction by the first method that the salmon will have resistance to infectious pancreatic necrosis.

Abstract: The Invention relates to a method of predicting resistance to infectious pancreatic necrosis in salmon, the method comprising determining the alleles present at a DNA polymorphism in the salmon and predicting whether or not the salmon is resistant to infectious pancreatic necrosis based on the determination of the alleles. The invention also relates to a method of selecting a salmon for use as broodstock, wherein the salmon is selected based on the prediction by the first method that the salmon will have resistance to infectious pancreatic necrosis.

Abstract: The present invention relates to methods of predicting resistance to heart and skeletal muscle inflammation in salmonids, the method comprising determining the alleles present at a DNA polymorphism in the salmonid and predicting whether or not the salmonid is resistant to heart and skeletal muscle inflammation based on the determination of the alleles. The invention also relates to related methods of detecting, in a sample from a salmonid, the alleles present at a DNA polymorphism associated with resistance to heart and skeletal muscle inflammation, methods for obtaining an indication of risk of a salmonid developing heart and skeletal muscle inflammation, uses of such DNA polymorphisms, and methods of detecting, in a sample from a salmonid, one or more salmonid gene variants.

Abstract: The present invention relates to a method of predicting the ability of a salmonid to utilise dietary pigment, the method comprising determining the alleles present at one or more DNA polymorphism in the abcg 2 gene in the salmonid and predicting the ability of the salmonid to utilise dietary pigment based on the determination of the alleles. Such a method may be used in a method of selecting a salmonid for use as broodstock. The present invention also relates to a method of genome editing in order to create a salmonid with an increased ability to utilise dietary pigment, the method comprising editing the genome of the salmonid in order to introduce one or more red allele of a DNA polymorphism in the abcg2 gene.

Abstract: The present invention relates to cache coherent node controllers for scale-up shared memory systems. In particular it is disclosed a computer system at least comprising a first group of CPU modules connected to at least one first FPGA Node Controller configured to execute transactions directly or through a first interconnect switch to at least one second FPGA Node Controller connected to a second group of CPU modules running a single instance of an operating system.

Abstract: The present invention relates to a method of predicting resistance to a viral infection in a subject, the method comprising determining in the subject the variant present at one or more amino acid position in a cadherin protein, and/or the alleles present at one or more DNA polymorphism in the gene for cadherin, and predicting whether or not the subject is resistant to viral infection based on the determination of the variant and/or the alleles.

Abstract: A computer system includes a first group of CPU modules operatively coupled to at least one first Programmable ASIC Node Controller configured to execute transactions directly or through a first interconnect switch to at least one second Programmable ASIC Node Controller connected to a second group of CPU modules running a single instance of an operating system.

Abstract: The present invention relates generally to single nucleotide polymorphisms (SNP) associated with increased resistance of a rainbow trout (Oncorhynchus mykiss)to infectious pancreatic necrosis (IPN). In particular, the present invention provides methods for predicting increased resistance of a rainbow trout to infectious pancreatic necrosis (IPN)and methods for selecting a rainbow trout having increased resistant to infectious pancreatic necrosis. The present invention further provides rainbow trout, rainbow trout cells and populations thereof carrying at least one allele conferring IPN resistance (“IPN resistance allele”) in their gen ome as well as nucleic acid molecules comprising nucleotide sequences associated with the SNPs of the present invention.

Abstract: The present invention relates to a method of predicting the ability of a salmonid to utilise dietary pigment, the method comprising determining the alleles present at one or more DNA polymorphism in the abcg 2 gene in the salmonid and predicting the ability of the salmonid to utilise dietary pigment based on the determination of the alleles. Such a method may be used in a method of selecting a salmonid for use as broodstock. The present invention also relates to a method of genome editing in order to create a salmonid with an increased ability to utilise dietary pigment, the method comprising editing the genome of the salmonid in order to introduce one or more red allele of a DNA polymorphism in the abcg2 gene.

Abstract: The Invention relates to a method of predicting resistance to infectious pancreatic necrosis in salmon, the method comprising determining the alleles present at a DNA polymorphism in the salmon and predicting whether or not the salmon is resistant to infectious pancreatic necrosis based on the determination of the alleles. The invention also relates to a method of selecting a salmon for use as broodstock, wherein the salmon is selected based on the prediction by the first method that the salmon will have resistance to infectious pancreatic necrosis.

Abstract: The Invention relates to a method of predicting resistance to infectious pancreatic necrosis in salmon, the method comprising determining the alleles present at a DNA polymorphism in the salmon and predicting whether or not the salmon is resistant to infectious pancreatic necrosis based on the determination of the alleles. The invention also relates to a method of selecting a salmon for use as broodstock, wherein the salmon is selected based on the prediction by the first method that the salmon will have resistance to infectious pancreatic necrosis.

Abstract: The Invention relates to a method of predicting resistance to infectious pancreatic necrosis in salmon, the method comprising determining the alleles present at a DNA polymorphism in the salmon and predicting whether or not the salmon is resistant to infectious pancreatic necrosis based on the determination of the alleles. The invention also relates to a method of selecting a salmon for use as broodstock, wherein the salmon is selected based on the prediction by the first method that the salmon will have resistance to infectious pancreatic necrosis.

Abstract: A method of predicting the ability of a salmon to utilise dietary pigment, the method comprising determining the alleles present at one or more DNA polymorphism in the salmon and predicting the ability of the salmon to utilise dietary pigment based on the determination of the alleles. The method may be used for selecting a salmon for use as broodstock. Also contemplated is a method of improving the ability of a salmon to utilise dietary pigment, the method including the step of administering an agent that inhibits the expression of the genes bcmo1-like and/or bcmo1 and/or an agent that inhibits the activities of the proteins Bcmo1-like and/or Bcmo1.