Patents by Inventor Thomas Muller-Spath
Thomas Muller-Spath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11460454Abstract: A method for monitoring, evaluating and controlling a cyclic chromatographic purification process that involves at least two adsorbers. According to the method, one step is monitoring of the chromatogram, including the measurement of at least one current concentration-proportional signal in the liquid. Another step is conducting an evaluation of the chromatogram, including a comparison of at least one of the current concentration-proportional signals measured in the monitoring step with a threshold value thereof. A further step is controlling the chromatographic purification process by adapting the termination of the currently running phase as a function of the comparison of the evaluation step and initiating the next phase. Finally, according to the method, the sequence of steps is carried out in given order at least twice.Type: GrantFiled: November 6, 2018Date of Patent: October 4, 2022Assignee: ChromaCon AGInventors: Lars Aumann, Thomas Müller-Späth, Michael Bavand
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Patent number: 11180526Abstract: A cyclic chromatographic purification method for the isolation of a product from a feed mixture consisting of the product and at least one further component representing impurities, which impurities bind stronger to the chromatographic stationary phase than the product is given. The method uses at least two chromatographic adsorbers as chromatographic stationary phase, grouped into only one first adsorber section (1) and one second adsorber section (2), wherein if an adsorber section comprises more than one chromatographic adsorber these are permanently connected in series, wherein the first adsorber section (1) has a first adsorber section inlet and a first adsorber section outlet, and the second adsorber section (1) has a second adsorber section inlet and a second adsorber section outlet.Type: GrantFiled: July 10, 2017Date of Patent: November 23, 2021Assignee: ChromaCon AGInventors: Thomas Müller-Späth, Lars Aumann, Michael Bavand
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Patent number: 10948483Abstract: Provided is a method for control and/or monitoring and/or optimization of a chromatographic process, in which the method comprises at least 2 columns which are operated, alternatingly, wherein this operation can be carried out in that the at least 2 columns are operated in interconnected and disconnected states, wherein the columns switch positions after such a sequence of interconnected and disconnected state, and wherein downstream of at least one, or of each column, a detector is located capable of detecting the desired product and/or impurities when passing the detector.Type: GrantFiled: May 11, 2017Date of Patent: March 16, 2021Assignee: ChromaCon AGInventors: Thomas Muller-Spath, Lars Aumann, Guido Strohlein, Michael Bavand, Nicole Ulmer
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Publication number: 20200355655Abstract: A method for monitoring, evaluating and controlling a cyclic chromatographic purification process that involves at least two adsorbers. According to the method, one step is monitoring of the chromatogram, including the measurement of at least one current concentration-proportional signal in the liquid. Another step is conducting an evaluation of the chromatogram, including a comparison of at least one of the current concentration-proportional signals measured in the monitoring step with a threshold value thereof. A further step is controlling the chromatographic purification process by adapting the termination of the currently running phase as a function of the comparison of the evaluation step and initiating the next phase. Finally, according to the method, the sequence of steps is carried out in given order at least twice.Type: ApplicationFiled: November 6, 2018Publication date: November 12, 2020Applicant: ChromaCon AGInventors: Lars AUMANN, Thomas MÜLLER-SPÄTH, Michael BAVAND
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Publication number: 20200031863Abstract: A cyclic chromatographic purification method for the isolation of a product from a feed mixture consisting of the product and at least one further component representing impurities, which impurities bind stronger to the chromatographic stationary phase than the product is given. The method uses at least two chromatographic adsorbers as chromatographic stationary phase, grouped into only one first adsorber section (1) and one second adsorber section (2), wherein if an adsorber section comprises more than one chromatographic adsorber these are permanently connected in series, wherein the first adsorber section (1) has a first adsorber section inlet and a first adsorber section outlet, and the second adsorber section (1) has a second adsorber section inlet and a second adsorber section outlet.Type: ApplicationFiled: July 10, 2017Publication date: January 30, 2020Applicant: ChromaCon AGInventors: Thomas MÜLLER-SPÄTH, Lars AUMANN, Michael BAVAND
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Publication number: 20190070523Abstract: A chromatographic purification method for the isolation of a desired product fraction from a mixture using 2 chromatographic columns, comprises, within one cycle to be carried out at least once, the following steps: a first batch step, wherein said columns are disconnected and a first column is loaded with feed and its outlet is directed to waste, and from a second column desired product is recovered and subsequently the second column is regenerated; a first interconnected step, wherein the outlet of the first column is connected to the inlet of the second column, the first column is loaded beyond its dynamic breakthrough capacity with feed, and the outlet of the second column is directed to waste, a second batch step analogous to the first batch step but with exchanged columns; and a second interconnected step, analogous to the first interconnected step but with exchanged columns.Type: ApplicationFiled: September 4, 2018Publication date: March 7, 2019Applicant: ChromaCon AGInventors: Thomas MULLER-SPATH, Lars AUMANN, Guido STROHLEIN, Michael BAVAND, Nicole ULMER
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Patent number: 10099156Abstract: A chromatographic purification method for the isolation of a desired product fraction from a mixture using 2 chromatographic columns, comprises, within one cycle to be carried out at least once, the following steps: a first batch step, wherein said columns are disconnected and a first column is loaded with feed and its outlet is directed to waste, and from a second column desired product is recovered and subsequently the second column is regenerated; a first interconnected step, wherein the outlet of the first column is connected to the inlet of the second column, the first column is loaded beyond its dynamic breakthrough capacity with feed, and the outlet of the second column is directed to waste, a second batch step analogous to the first batch step but with exchanged columns; and a second interconnected step, analogous to the first interconnected step but with exchanged columns.Type: GrantFiled: January 31, 2014Date of Patent: October 16, 2018Assignee: ChromaCon AGInventors: Thomas Müller-Späth, Lars Aumann, Guido Strohlein, Michael Bavand, Nicole Ulmer
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Publication number: 20170241992Abstract: Provided is a method for control and/or monitoring and/or optimization of a chromatographic process, in which the method comprises at least 2 columns which are operated, alternatingly, wherein this operation can be carried out in that the at least 2 columns are operated in interconnected and disconnected states, wherein the columns switch positions after such a sequence of interconnected and disconnected state, and wherein downstream of at least one, or of each column, a detector is located capable of detecting the desired product and/or impurities when passing the detector.Type: ApplicationFiled: May 11, 2017Publication date: August 24, 2017Applicant: ChromaCon AGInventors: Thomas MULLER-SPATH, Lars AUMANN, Guido STROHLEIN, Michael BAVAND, Nicole ULMER
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Patent number: 9073970Abstract: A chromatographic process for the enrichment of at least one compound of interest from a mixture is proposed, using chromatographic columns, wherein said process involves a sequence of the following steps: (i) a cyclic accumulation phase, in which the chromatographic columns are alternatingly operated in an interconnected phase, followed by a disconnected phase, wherein subsequently columns exchange places and wherein the phases are carried out sequentially; (ii) a cyclic separation phase, in which the chromatographic columns are alternatingly operated in an interconnected phase, followed by a disconnected phase, wherein after these phases columns exchange places to undergo the next interconnected and disconnected phases; and (iii) an elution phase, in which from the column, which at the end of phase (i) or at the end of phase (ii) contains the compound of interest, is extracted via the outlet.Type: GrantFiled: January 29, 2014Date of Patent: July 7, 2015Assignee: ChromaCon AGInventors: Thomas Müller-Späth, Guido Ströhlein, Lars Aumann, Michael Bavand, Nicole Ulmer
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Patent number: 9018137Abstract: The document pertains to a method for the purification of a ternary mixture of dimeric antibodies of the type AA, AB, BB, characterized in that for the separation of the three components and in particular for the isolation of the multi-specific fraction AB multicolumn counter current solvent gradient purification chromatography with a stationary phase load of more than 1 mg antibody mixture per milliliter stationary phase is used. It furthermore relates to a method for the identification of in particular bispecific antibody systems, which are particularly suitable for the application of such a purification method.Type: GrantFiled: March 15, 2012Date of Patent: April 28, 2015Assignee: ChromaCon AGInventors: Thomas Müller-Späth, Lars Aumann, Guido Ströhlein, Michael Bavand
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Publication number: 20140299547Abstract: A chromatographic purification method for the isolation of a desired product fraction from a mixture using 2 chromatographic columns, comprises, within one cycle to be carried out at least once, the following steps: a first batch step, wherein said columns are disconnected and a first column is loaded with feed and its outlet is directed to waste, and from a second column desired product is recovered and subsequently the second column is regenerated; a first interconnected step, wherein the outlet of the first column is connected to the inlet of the second column, the first column is loaded beyond its dynamic breakthrough capacity with feed, and the outlet of the second column is directed to waste, a second batch step analogous to the first batch step but with exchanged columns; and a second interconnected step, analogous to the first interconnected step but with exchanged columns.Type: ApplicationFiled: January 31, 2014Publication date: October 9, 2014Applicant: ChromaCon AGInventors: Thomas MULLER-SPATH, Lars AUMANN, Guido STROHLEIN, Michael BAVAND, Nicole ULMER
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Publication number: 20140248643Abstract: A chromatographic process for the enrichment of at least one compound of interest from a mixture is proposed, using chromatographic columns, wherein said process involves a sequence of the following steps: (i) a cyclic accumulation phase, in which the chromatographic columns are alternatingly operated in an interconnected phase, followed by a disconnected phase, wherein subsequently columns exchange places and wherein the phases are carried out sequentially; (ii) a cyclic separation phase, in which the chromatographic columns are alternatingly operated in an interconnected phase, followed by a disconnected phase, wherein after these phases columns exchange places to undergo the next interconnected and disconnected phases; and (iii) an elution phase, in which from the column, which at the end of phase (i) or at the end of phase (ii) contains the compound of interest, is extracted via the outlet.Type: ApplicationFiled: January 29, 2014Publication date: September 4, 2014Applicant: CHROMACON AGInventors: Thomas MÜLLER-SPÄTH, Guido STRÖHLEIN, Lars AUMANN, Michael BAVAND, Nicole ULMER
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Publication number: 20140045725Abstract: The document pertains to a method for the purification of a ternary mixture of dimeric antibodies of the type AA, AB, BB, characterised in that for the separation of the three components and in particular for the isolation of the multi-specific fraction AB multicolumn counter current solvent gradient purification chromatography with a stationary phase load of more than 1 mg antibody mixture per millilitre stationary phase is used. It furthermore relates to a method for the identification of in particular bispecific antibody systems, which are particularly suitable for the application of such a purification method.Type: ApplicationFiled: March 15, 2012Publication date: February 13, 2014Applicant: CHROMACON AGInventors: Thomas Muller-Spath, Lars Aumann, Guido Ströhlein, Michael Bavand
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Patent number: 8440086Abstract: A process for continuous or quasi-continuous purification of a multi-component mixture by means of at least four individual chromatographic columns through which the mixture is fed by means of at least one solvent, is given, wherein the multi-component mixture is to be separated into an integer number n of fractions, wherein n is at least 5.Type: GrantFiled: December 16, 2009Date of Patent: May 14, 2013Assignee: ChromaCon AGInventors: Thomas Müller-Späth, Lars Aumann
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Publication number: 20110253631Abstract: A process for continuous or quasi-continuous purification of a multi-component mixture (Fd) by means of at least four individual chromatographic columns through which the mixture is fed by means of at least one solvent (s), is given, wherein the multicomponent mixture (Fd) is to be separated into an integer number n of fractions (Fi), wherein n is at least 5. The columns are grouped into at least six sections ((?1, . . . , ?n-3, ?1, . . . , ?n-3, Y, ?), wherein each section ((?1, . . . , ?n-3, ?i, . . . , ?n-3, ?, ?) comprises at least one column with the proviso that the function of sections can be fulfilled sequentially and can be realized by single columns. There are least two collection, at least two recycling sections (?1, . . . , ?n-3), a strongly adsorbing component collection section (?) and a feed section (?) The functions of the sections ((?1, . . . , ?n-3, ?i, . . .Type: ApplicationFiled: December 16, 2009Publication date: October 20, 2011Applicant: CHROMACON AGInventors: Thomas Muller-Spath, Lars Aumann