Patents by Inventor Thomas P. Brent

Thomas P. Brent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Homogeneous denatured human 06-guanine alkyltransferase prepared by immunoaffinity chromatography using monoclonal antibody specific for enzyme
    Patent number: 5316932
    Abstract: A denatured human O.sup.6 -guanine alkyltransferase is disclosed. The enzyme is prepared by a process which involves denaturing the enzyme, contacting the denatured enzyme with a monoclonal antibody specific for the denatured enzyme on a substrate to which the monoclonal antibody is bound to, so that the denatured enzyme and the monoclonal antibody form an immunocomplex and then, eluting the denatured enzyme from the substrate-bound monoclonal antibody so that the denatured human O.sup.6 -guanine alkyltransferase is obtained. The enzyme can be used to develop probes for the Mer.sup.- phenotype and these probes in turn are contemplated for use in identifying drug resistant tumors in patients.
    Type: Grant
    Filed: May 11, 1993
    Date of Patent: May 31, 1994
    Assignees: Duke University, St. Jude Children's Research Hospital
    Inventors: Darell D. Bigner, Thomas P. Brent