Patents by Inventor Thomas P. Castellano
Thomas P. Castellano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6824526Abstract: A needle-less injector suitable for injecting fluid through a surface includes a housing, a driver, an engine and a trigger. The housing contains a fluid and the engine contains a compressed gas. Upon application of sufficient force to the trigger, the compressed gas is released from the engine forcing the driver through the interior of the housing, expelling the fluid from the housing at a speed sufficient to pierce an injection surface. An aerodynamic diffuser maximizes air flow to the driver, allowing greater injection speed and mitigating pain associated with receiving an injection. Use of the injector is both silent and easy to activate, owing to an O-ring included about the circumference of the exterior of a diffuser operating within the engine. Further, the engine has safety features preventing a portion thereof from separating from the device under elevated temperatures and similar conditions. Engine leakage is obviated by the inclusion of a leakage ring therein.Type: GrantFiled: October 22, 2001Date of Patent: November 30, 2004Assignee: Penjet CorporationInventor: Thomas P Castellano
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Patent number: 6755220Abstract: Devices and methods are described for filling or refilling a needle-less injector. A coupling device is attached to a vessel, and mated to the dispensing end of a needle-less injector. A volume of fluid may be transferred via the coupling device, from the vessel to the injector. Air may be removed from the injector prior to the injector, vessel, and coupling device being separated from one another. In alternate embodiments, the vessel may include filling equipment capable of filling or refilling multiple needle-less injectors simultaneously, in series, or both. In other embodiments, a coupling device may be used to withdraw a fluid from a storage vial into a vessel for filling a needle-less injector. A storage vial may alternately contain a product, and a fluid may be introduced therein via a coupling device to create a mixture, which may be subsequently withdrawn into a vessel for filling a needle-less injector.Type: GrantFiled: April 25, 2002Date of Patent: June 29, 2004Assignee: Penjet CorporationInventors: Thomas P. Castellano, Roger R. Wise, Seth D. Levy
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Publication number: 20040035491Abstract: Apparatuses and methods are described for administering a needle-less injection of a degassed fluid. Prior to filling, or after filling but prior to administration of a needle-less injection, gas is removed from the fluid. A needle-less injection may then be performed with a reduced risk of discomfort to the recipient of the injection and with lower potential for the creation of a subdermal hematoma as a result of the injection. A wide variety of needle-less injectors may be used in accordance with various embodiments of the present invention.Type: ApplicationFiled: August 26, 2002Publication date: February 26, 2004Applicant: PenJet CorporationInventor: Thomas P. Castellano
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Patent number: 6673034Abstract: A needle-less injector suitable for injecting fluid through a skin surface of a patient includes a housing, a driver, an intruding gas chamber activating mechanism and a trigger. The housing containing the fluid and a sealed gas storage chamber containing a gas. The driver forces the fluid out of the housing at a sufficient speed to pierce the skin surface of the patient. The intruding gas chamber activating mechanism is mounted in the housing to intrude through the sealed gas chamber to release gas seal into the housing. The trigger is operatively coupled to the intruding gas chamber activating mechanism to release the gas from the gas chamber into the housing to activate the driver to force the fluid out of the housing. The trigger is activated by moving the trigger towards and orifice in the housing and/or upon application of a predetermined amount of pressure to the trigger that is opposed by a predetermined amount of resistance from the skin surface of the patient.Type: GrantFiled: March 18, 2002Date of Patent: January 6, 2004Assignee: Penjet CorporationInventor: Thomas P. Castellano
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Patent number: 6613011Abstract: An engine with a valve suitable for containing compressed gas and expelling the same upon opening of the valve is provided. Upon application of sufficient force to an element of the valve, the compressed gas is released from the engine. In one embodiment, the engine is fitted with a reusable valve. In another embodiment, the engine includes an engine housing with a pop-out feature that indicates if the engine is critically overcharged. A method of implementing quality control schemes during the manufacture or production of the engine and its component parts is provided, as well as a method of filling the engine with a compressed gas.Type: GrantFiled: March 15, 2002Date of Patent: September 2, 2003Assignee: Penjet CorporationInventor: Thomas P Castellano
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Patent number: 6613010Abstract: A needle-less injector suitable for injecting fluid through a surface includes a housing, a driver, an engine and a trigger. The housing contains a fluid and the engine contains a compressed gas. Upon application of sufficient force to the trigger, the compressed gas is released from the engine forcing the driver through the interior of the housing, expelling the liquid from the housing at a speed sufficient to pierce an injection surface. In one embodiment, the needle-less injector includes a mechanism for mitigating the kickback associated with releasing compressed gas from the engine. In another embodiment, the housing includes finger rests that provide stability and resistance to activate the device. In another embodiment, the engine is fitted with a reusable valve.Type: GrantFiled: April 13, 2001Date of Patent: September 2, 2003Assignee: PenJet CorporationInventor: Thomas P. Castellano
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Publication number: 20030083612Abstract: A needle-less injector suitable for injecting fluid through a surface includes a housing, a driver, an engine and a trigger. The housing contains a fluid and the engine contains a compressed gas. Upon application of sufficient force to the trigger, the compressed gas is released from the engine forcing the driver through the interior of the housing, expelling the liquid from the housing at a speed sufficient to pierce an injection surface. In one embodiment, the needle-less injector includes a mechanism for mitigating the kickback associated with releasing compressed gas from the engine. In another embodiment, the housing includes finger rests that provide stability and resistance to activate the device. In another embodiment, the engine is fitted with a reusable valve. In another embodiment, a safety clamp is included on the housing, preventing accidental activation of the device.Type: ApplicationFiled: August 26, 2002Publication date: May 1, 2003Applicant: PenJet CorporationInventor: Thomas P. Castellano
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Publication number: 20030078535Abstract: A needle-less injector suitable for injecting fluid through a surface includes a housing, a driver, an engine and a trigger. The housing contains a fluid and the engine contains a compressed gas. Upon application of sufficient force to the trigger, the compressed gas is released from the engine forcing the driver through the interior of the housing, expelling the fluid from the housing at a speed sufficient to pierce an injection surface. An aerodynamic diffuser maximizes air flow to the driver, allowing greater injection speed and mitigating pain associated with receiving an injection. Use of the injector is both silent and easy to activate, owing to an O-ring included about the circumference of the exterior of a diffuser operating within the engine. Further, the engine has safety features preventing a portion thereof from separating from the device under elevated temperatures and similar conditions. Engine leakage is obviated by the inclusion of a leakage ring therein.Type: ApplicationFiled: October 22, 2001Publication date: April 24, 2003Applicant: Pen Jet CorporationInventor: Thomas P. Castellano
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Patent number: 6500239Abstract: A system and multiple methods are described for removing dissolved gases from a liquid either prior to or following filling into a container. Prior to filling, gas is removed by creating a pressure differential, by application of heat, by sonication, or by generating a liquid by combination of dry solute and de-gassed solvent. Alternatively, liquids may be highly concentrated with solute to force any dissolved gas out of solution and later diluted with de-gassed solvents. In other embodiments, gases are percolated into liquids to displace atmospheric gases, wherein these percolated gases separate from solution and diffuse out of sealed contained after filling either by nature of their molecular size or chemical reaction with materials constructed into the container.Type: GrantFiled: March 14, 2001Date of Patent: December 31, 2002Assignee: Penjet CorporationInventors: Thomas P. Castellano, Eloy A. Ituarte
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Patent number: 6474369Abstract: A device for storing and mixing an injectate includes a fluid holder removably coupled to an ampoule. The fluid holder initially contains a fluid and the ampoule initially contains a dry reagent. A breakable membrane may be included between the fluid holder and ampoule to prevent the undesirable mixing of the fluid with the dry reagent. Upon application of force to a plunger rod disposed within the fluid holder, fluid is introduced into the ampoule wherein it is mixed with the dry reagent to create an injectable mixture. Air or gas present in the ampoule may be removed therefrom; the fluid holder may be decoupled from the ampoule; and the ampoule may be further coupled to a needle-less injector for administration of an injection of the mixture. The device is particularly useful for lyophilized pharmaceuticals that rapidly lose medicinal efficacy once in solution form.Type: GrantFiled: December 26, 2001Date of Patent: November 5, 2002Assignee: Penjet CorporationInventor: Thomas P Castellano
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Publication number: 20020161334Abstract: Devices and methods are described for filling or refilling a needle-less injector. A coupling device is attached to a vessel, and mated to the dispensing end of a needle-less injector. A volume of fluid may be transferred via the coupling device, from the vessel to the injector. Air may be removed from the injector prior to the injector, vessel, and coupling device being separated from one another. In alternate embodiments, the vessel may include filling equipment capable of filling or refilling multiple needle-less injectors simultaneously, in series, or both. In other embodiments, a coupling device may be used to withdraw a fluid from a storage vial into a vessel for filling a needle-less injector. A storage vial may alternately contain a product, and a fluid may be introduced therein via a coupling device to create a mixture, which may be subsequently withdrawn into a vessel for filling a needle-less injector.Type: ApplicationFiled: April 25, 2002Publication date: October 31, 2002Applicant: PENJET CORPORATIONInventors: Thomas P. Castellano, Roger R. Wise, Seth D. Levy
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Publication number: 20020151841Abstract: An engine with a valve suitable for containing compressed gas and expelling the same upon opening of the valve is provided. Upon application of sufficient force to an element of the valve, the compressed gas is released from the engine. In one embodiment, the engine is fitted with a reusable valve. In another embodiment, the engine includes an engine housing with a pop-out feature that indicates if the engine is critically overcharged. A method of implementing quality control schemes during the manufacture or production of the engine and its component parts is provided, as well as a method of filling the engine with a compressed gas.Type: ApplicationFiled: March 15, 2002Publication date: October 17, 2002Applicant: PENJET CORPORATIONInventor: Thomas P. Castellano
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Publication number: 20020151840Abstract: A needle-less injector suitable for injecting fluid through a surface includes a housing, a driver, an engine and a trigger. The housing contains a fluid and the engine contains a compressed gas. Upon application of sufficient force to the trigger, the compressed gas is released from the engine forcing the driver through the interior of the housing, expelling the liquid from the housing at a speed sufficient to pierce an injection surface. In one embodiment, the needle-less injector includes a mechanism for mitigating the kickback associated with releasing compressed gas from the engine. In another embodiment, the housing includes finger rests that provide stability and resistance to activate the device. In another embodiment, the engine is fitted with a reusable valve. In another embodiment, a safety clamp is included on the housing, preventing accidental activation of the device.Type: ApplicationFiled: April 13, 2001Publication date: October 17, 2002Inventor: Thomas P. Castellano
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Publication number: 20020129705Abstract: A system and multiple methods are described for removing dissolved gases from a liquid either prior to or following filling into a container. Prior to filling, gas is removed by creating a pressure differential, by application of heat, by sonication, or by generating a liquid by combination of dry solute and de-gassed solvent. Alternatively, liquids may be highly concentrated with solute to force any dissolved gas out of solution and later diluted with de-gassed solvents. In other embodiments, gases are percolated into liquids to displace atmospheric gases, wherein these percolated gases separate from solution and diffuse out of sealed containers after filling either by nature of their molecular size or chemical reaction with materials constructed into the container.Type: ApplicationFiled: March 14, 2001Publication date: September 19, 2002Inventors: Thomas P. Castellano, Eloy A. Ituarte
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Patent number: 6447475Abstract: A needle-less injector suitable for injecting fluid through a skin surface of a patient includes a housing, a driver, an intruding gas chamber activating mechanism and a trigger. The housing containing the fluid and a sealed gas storage chamber containing a gas. The driver forces the fluid out of the housing at a sufficient speed to pierce the skin surface of the patient. The intruding gas chamber activating mechanism is mounted in the housing to intrude through the sealed gas chamber to release gas seal into the housing. The trigger is operatively coupled to the intruding gas chamber activating mechanism to release the gas from the gas chamber into the housing to activate the driver to force the fluid out of the housing. The trigger is activated by moving the trigger towards and orifice in the housing and/or upon application of a predetermined amount of pressure to the trigger that is opposed by a predetermined amount of resistance from the skin surface of the patient.Type: GrantFiled: May 6, 2000Date of Patent: September 10, 2002Assignee: Pen Jet CorporationInventor: Thomas P. Castellano
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Publication number: 20020099329Abstract: A needle-less injector suitable for injecting fluid through a skin surface of a patient includes a housing, a driver, an intruding gas chamber activating mechanism and a trigger. The housing containing the fluid and a sealed gas storage chamber containing a gas. The driver forces the fluid out of the housing at a sufficient speed to pierce the skin surface of the patient. The intruding gas chamber activating mechanism is mounted in the housing to intrude through the sealed gas chamber to release gas seal into the housing. The trigger is operatively coupled to the intruding gas chamber activating mechanism to release the gas from the gas chamber into the housing to activate the driver to force the fluid out of the housing. The trigger is activated by moving the trigger towards and orifice in the housing and/or upon application of a predetermined amount of pressure to the trigger that is opposed by a predetermined amount of resistance from the skin surface of the patient.Type: ApplicationFiled: March 18, 2002Publication date: July 25, 2002Applicant: Pen Jet CorporationInventor: Thomas P. Castellano
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Publication number: 20020056486Abstract: A device for storing and mixing an injectate includes a fluid holder removably coupled to an ampoule. The fluid holder initially contains a fluid and the ampoule initially contains a dry reagent. A breakable membrane may be included between the fluid holder and ampoule to prevent the undesirable mixing of the fluid with the dry reagent. Upon application of force to a plunger rod disposed within the fluid holder, fluid is introduced into the ampoule wherein it is mixed with the dry reagent to create an injectable mixture. Air or gas present in the ampoule may be removed therefrom; the fluid holder may be decoupled from the ampoule; and the ampoule may be further coupled to a needle-less injector for administration of an injection of the mixture. The device is particularly useful for lyophilized pharmaceuticals that rapidly lose medicinal efficacy once in solution form.Type: ApplicationFiled: December 26, 2001Publication date: May 16, 2002Applicant: PENJET CORPORATIONInventor: Thomas P. Castellano
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Patent number: 6302160Abstract: An apparatus for filling an ampule of a needle-less injector suitable for injecting liquid medication includes an ampule and a fluid holder. The ampule is for containing the fluid, and the fluid holder is for delivering the fluid. The fluid holder also includes a fluid plunger rod. The ampule is coupled to the fluid holder to provide fluid communication between the ampule and the fluid holder. The fluid plunger rod is depressed to load the fluid from the fluid holder into the ampule to fill the ampule. The ampule may further include an ampule plunger rod. After the ampule is loaded with fluid, the ampule plunger rod is depressed to expel bubbles back into the fluid holder from the ampule.Type: GrantFiled: November 3, 1999Date of Patent: October 16, 2001Assignee: Pen Jet CorporationInventor: Thomas P. Castellano
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Publication number: 20010018935Abstract: An apparatus for filling an ampule of a needle-less injector suitable for injecting liquid medication includes an ampule and a fluid holder. The ampule is for containing the fluid, and the fluid holder is for delivering the fluid. The fluid holder also includes a fluid plunger rod. The ampule is coupled to the fluid holder to provide fluid communication between the ampule and the fluid holder. The fluid plunger rod is depressed to load the fluid from the fluid holder into the ampule to fill the ampule. The ampule may further includes an ampule plunger rod. After the ampule is loaded with fluid, the ampule plunger rod is depressed to expel bubbles back into the fluid holder from the ampule.Type: ApplicationFiled: November 3, 1999Publication date: September 6, 2001Applicant: PEN JET CORPORATIONInventor: THOMAS P CASTELLANO
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Patent number: D483116Type: GrantFiled: April 5, 2002Date of Patent: December 2, 2003Assignee: Penjet CorporationInventor: Thomas P Castellano