Patents by Inventor Thomas P. McNicholas

Thomas P. McNicholas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Photoluminescent nanostructure-based sensors
    Patent number: 9980668
    Abstract: A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: May 29, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Paul W. Barone, Jin-Ho Ahn, Kyungsuk Yum, Thomas P. McNicholas
  • Near infrared fluorescent single walled carbon nanotubes as tissue localizable biosensors
    Patent number: 9901295
    Abstract: A nanosensor for detecting an analyte can include a substrate, a photoluminescent nanostructure, and a polymer interacting with the photoluminescent nanostructure. The nanosensor can be used in in vivo for biomedical applications.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: February 27, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Nicole M. Iverson, Michael S. Strano, Nigel F. Reuel, Thomas P. McNicholas
  • SACCHARIDE RESPONSIVE OPTICAL NANOSENSORS
    Publication number: 20170131287
    Abstract: A composition for sensing an analyte can include a photoluminescent nanostructure (e.g. a carbon nanotube) complexed to a sensing polymer, where the sensing polymer includes a phenylboronic acid based polymer non-covalently bound to the photoluminescent nanostructure where the composition is capable of selectively binding the analyte, and the composition undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte can include a complex, where the complex include a photoluminescent nanostructure in an aqueous surfactant dispersion and a phenylboronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.
    Type: Application
    Filed: June 5, 2015
    Publication date: May 11, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Thomas P. McNicholas, Jiyoung Ahn, Michael S. Strano
  • Compositions, methods, and systems for separating carbon-based nanostructures
    Patent number: 9403684
    Abstract: The present invention generally relates to compositions, methods, and systems for separating carbon-based nanostructures.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: August 2, 2016
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Thomas P. McNicholas, Andrew J. Hilmer, Rishabh M. Jain, Kevin C. Tvrdy
  • NEAR INFRARED FLUORESCENT SINGLE WALLED CARBON NANOTUBES AS TISSUE LOCALIZABLE BIOSENSORS
    Publication number: 20150133752
    Abstract: A nanosensor for detecting an analyte can include a substrate, a photoluminescent nanostructure, and a polymer interacting with the photoluminescent nanostructure. The nanosensor can be used in in vivo for biomedical applications.
    Type: Application
    Filed: September 16, 2014
    Publication date: May 14, 2015
    Inventors: Nicole M. Iverson, Michael S. Strano, Nigel F. Reuel, Thomas P. McNicholas
  • COMPOSITIONS, METHODS, AND SYSTEMS FOR SEPARATING CARBON-BASED NANOSTRUCTURES
    Publication number: 20140199229
    Abstract: The present invention generally relates to compositions, methods, and systems for separating carbon-based nanostructures.
    Type: Application
    Filed: March 14, 2013
    Publication date: July 17, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Michael S. Strano, Thomas P. McNicholas, Andrew J. Hilmer, Rishabh M. Jain, Kevin C. Tvrdy
  • PHOTOLUMINESCENT NANOSTRUCTURE-BASED SENSORS
    Publication number: 20130035567
    Abstract: A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.
    Type: Application
    Filed: July 31, 2012
    Publication date: February 7, 2013
    Inventors: Michael S. Strano, Paul W. Barone, Jin-Ho Ahn, Kyungsuk Yum, Thomas P. McNicholas