Patents by Inventor Thomas P. Monath

Thomas P. Monath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric flavivirus vaccines
    Publication number: 20100278773
    Abstract: A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.
    Type: Application
    Filed: November 25, 2009
    Publication date: November 4, 2010
    Inventors: Thomas J. Chambers, Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo
  • West Nile Virus Vaccine
    Publication number: 20100086564
    Abstract: The invention provides chimeric flavivirus vaccines against West Nile virus and methods of using these vaccines to prevent or treat West Nile virus infection.
    Type: Application
    Filed: March 23, 2009
    Publication date: April 8, 2010
    Applicant: Sanofi Pasteur Biologics Co.
    Inventors: Juan Arroyo, Charles Miller, John Avram Catalan, Thomas P. Monath
  • Vaccinia virus strains
    Patent number: 7645456
    Abstract: The invention provides attenuated vaccinia virus vaccines that can be used in methods to prevent or treat small pox in patients, as well as methods of obtaining such vaccines.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: January 12, 2010
    Assignee: Sanofi Pasteur Biologics Co.
    Inventors: Richard A. Weltzin, Thomas P. Monath
  • Vaccinia Virus Strains
    Publication number: 20090324548
    Abstract: The invention provides attenuated vaccinia virus vaccines that can be used in methods to prevent or treat small pox in patients, as well as methods of obtaining such vaccines.
    Type: Application
    Filed: January 15, 2009
    Publication date: December 31, 2009
    Inventors: Richard A. Weltzin, Thomas P. Monath
  • Flavivirus Vaccines
    Publication number: 20090191240
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Application
    Filed: December 1, 2008
    Publication date: July 30, 2009
    Inventors: Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo, Konstantin Pugachev
  • VACCINIA VIRUS STRAINS
    Publication number: 20090169512
    Abstract: The invention provides attenuated vaccinia virus vaccines that can be used in methods to prevent or treat small pox in patients, as well as methods of obtaining such vaccines.
    Type: Application
    Filed: April 16, 2004
    Publication date: July 2, 2009
    Inventors: Richard A. Weltzin, Thomas P. Monath
  • West nile virus vaccine
    Patent number: 7507415
    Abstract: The invention provides chimeric flavivirus vaccines against West Nile virus and methods of using these vaccines to prevent or treat West Nile virus infection.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: March 24, 2009
    Assignee: Acambis Inc.
    Inventors: Juan Arroyo, Charles Miller, John Avram Catalan, Thomas P. Monath
  • Chimeric flaviviruses
    Patent number: 7459160
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: December 2, 2008
    Assignee: Acambis Inc.
    Inventors: Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo, Konstantin Pugachev
  • CHIMERIC FLAVIVIRUSES
    Publication number: 20080274142
    Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
    Type: Application
    Filed: January 15, 2003
    Publication date: November 6, 2008
    Inventors: Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo, Konstantin Pugachev
  • Vaccination Against Dengue Virus Infection
    Publication number: 20080193477
    Abstract: This invention relates to methods and kits for use in vaccination against dengue virus infection.
    Type: Application
    Filed: August 9, 2006
    Publication date: August 14, 2008
    Applicants: Acambis Inc., Sanofi Pasteur SA
    Inventors: Thomas P. Monath, Farshad Guirakhoo, Niranjan Kanesa-thasan, Thomas H. Ermak, Jean Lang, Remi Forrat
  • Recombinant Flavivirus Vaccines
    Publication number: 20080175862
    Abstract: The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
    Type: Application
    Filed: April 24, 2006
    Publication date: July 24, 2008
    Applicant: Acambis Inc.
    Inventors: Konstantin V. Pugachev, Farshad Guirakhoo, Thomas P. Monath
  • Smallpox vaccine
    Patent number: 7115270
    Abstract: The invention provides attenuated vaccinia virus vaccines that can be used in methods to prevent or treat small pox in patients, as well as methods of obtaining such vaccines.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: October 3, 2006
    Assignee: Acambis Inc.
    Inventors: Richard A. Weltzin, Thomas P. Monath
  • Active immunization against clostridium difficile disease
    Patent number: 6969520
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: November 29, 2005
    Assignee: Acambis Inc.
    Inventors: William D. Thomas, Jr., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Chimeric flavivirus vaccines
    Patent number: 6962708
    Abstract: A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: November 8, 2005
    Assignees: Acambis, Inc., St. Louis University
    Inventors: Thomas J. Chambers, Thomas P. Monath, Farshad Guirakhoo, Juan Arroyo
  • Methods of preventing and treating flavivirus infection in animals
    Patent number: 6878372
    Abstract: The invention provides methods of preventing and treating flavivirus infection in animals.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: April 12, 2005
    Assignee: Acambis Inc.
    Inventors: Thomas P. Monath, Juan Arroyo
  • Chimeric flavivirus vaccines
    Publication number: 20040223979
    Abstract: A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.
    Type: Application
    Filed: November 4, 2003
    Publication date: November 11, 2004
    Inventors: Thomas J. Chambers, Thomas P. Monath, Farshad Guirakhoo, Juan Arroy
  • Passive immunization against Clostridium difficile disease
    Publication number: 20040126383
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: December 16, 2003
    Publication date: July 1, 2004
    Inventors: William D. Thomas, Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Smallpox vaccine
    Patent number: 6723325
    Abstract: The invention provides attenuated vaccinia virus vaccines that can be used in methods to prevent or treat small pox in patients, as well as methods of obtaining such vaccines.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: April 20, 2004
    Assignee: Acambis, Inc.
    Inventors: Richard A. Weltzin, Thomas P. Monath
  • Stabilization of helicobacter urease
    Patent number: 6709851
    Abstract: The invention provides methods for stabilizing recombinant Helicobacter urease by genetically modifying a urease amino acid. The stabilized urease is prevented from the molecular aggregation or activation (e.g., in vitro activation) characteristic of untreated urease.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: March 23, 2004
    Assignee: OraVax-Merieux Co.
    Inventors: Gopalan Soman, William D. Thomas, Jr., Thomas P. Monath
  • Chimeric flavivirus vaccines
    Patent number: 6696281
    Abstract: A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: February 24, 2004
    Assignees: Acambis, Inc., St. Louis University
    Inventors: Thomas J. Chambers, Thomas P. Monath, Farshad Guirakhoo