Patents by Inventor Thomas P. Tully

Thomas P. Tully has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Betulinic acid derivatives with HIV maturation inhibitory activity
    Patent number: 9920090
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivaties that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: March 20, 2018
    Assignee: ViiV HEALTHCARE UK (NO.5) LIMITED
    Inventors: Alicia Regueiro-Ren, Animesh Goswami, Zhiwei Guo, Thomas P. Tully, Jacob Swidorski, Zheng Liu, Nicholas A. Meanwell
  • BETULINIC ACID DERIVATIVES WITH HIV MATURATION INHIBITORY ACTIVITY
    Publication number: 20170204133
    Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivaties that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: June 17, 2015
    Publication date: July 20, 2017
    Inventors: Alicia REGUEIRO-REN, Animesh GOSWAMI, Zhiwei GUO, Thomas P. TULLY, Jacob SWIDORSKI, Zheng LIU, Nicholas A. MEANWELL
  • Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B
    Patent number: 7172884
    Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: February 6, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel Benigni, Robert Stankavage, Shu-Jen Chiang, Hsing Hou, Bruce Eagan, Dennis Gu, David Hou, Les Mintzmyer, Thomas P. Tully, Brian L. Davis, Ivan Hargro, Mark Mascari, Gabriel Galvin, Gregory Stein, Cary W. McConlogue, Fahri T. Comezoglu
  • Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B
    Publication number: 20040132146
    Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
    Type: Application
    Filed: September 22, 2003
    Publication date: July 8, 2004
    Inventors: Daniel Benigni, Robert Stankavage, Shu-Jen Chiang, Hsing Hou, Bruce Eagan, Dennis Gu, David Hou, Les Mintzmyer, Thomas P. Tully, Brian L. Davis, Ivan Hargro, Mark Mascari, Gabriel Galvin, Gregory Stein, Cary W. McConlogue, Fahri T. Comezoglu
  • Enzymatic oxidative deamination process
    Patent number: 6515170
    Abstract: The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: February 4, 2003
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Ramesh N. Patel, Amit Banerjee, Venkata B. Nanduri, Steven L. Goldberg, Robert M. Johnston, Thomas P. Tully, Laszlo J. Szarka, Shankar Swaminathan, John J. Venit, Jerome L. Moniot, William J. Winter, Neal G. Anderson, David A. Lust, Gerard Crispino, Sushil K. Srivastava
  • Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
    Patent number: RE42191
    Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: March 1, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel Benigni, Thomas P. Tully, Brian L. Davis