Abstract: The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.

Abstract: A method of managing an online support group to increase the odds that users will attain their wellness goals is disclosed. A request from a user to join a support group is received. A preference of the user with respect to a type of the support group is received. The support group is selected from a plurality of support groups based on the preference of the user and a preference of a member of the support group. Based on an acceptance by the user of an option to join the support group, the plurality of support groups is reorganized.

Abstract: Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.

Abstract: A machine includes a hydraulic cylinder configured to raise and lower a boom of the machine, and an accumulator selectively fluidly connected to the hydraulic cylinder. The accumulator is configured to receive fluid from the hydraulic cylinder during lowering of the boom. The machine also includes a hydraulic motor fluidly connected to the accumulator via an independent metering valve. The machine further includes a fan driven by the hydraulic motor and configured to assist in cooling fluid displaced from the hydraulic cylinder.

Abstract: The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.

Abstract: A hydraulic system for a machine is disclosed. The hydraulic system has a source of pressurized fluid, a fluid actuator, and a tank. The hydraulic system utilizes a directional control valve to direct flow between the source, the actuator, and the tank. The hydraulic further utilizes a variable backpressure control valve to control the system backpressure.

Abstract: WIRE jT is designed to facilitate efficient splicing of wires when installing after-market items into vehicles. Many consumers may add various features to their vehicles, such as lights, speaker systems, and other items that require re-wiring. WIRE jT provides mechanics with a way to easily and effectively splice wires. WIRE jT is principally used for wire splicing.

Abstract: A machine includes a hydraulic cylinder configured to raise and lower a boom of the machine, and an accumulator selectively fluidly connected to the hydraulic cylinder. The accumulator is configured to receive fluid from the hydraulic cylinder during lowering of the boom. The machine also includes a hydraulic motor fluidly connected to the accumulator via an independent metering valve. The machine further includes a fan driven by the hydraulic motor and configured to assist in cooling fluid displaced from the hydraulic cylinder.

Abstract: A regeneration valve for a hydraulic circuit may include a valve element for controlling flow between first, second, and third ports. The valve element may be formed with a flow slot that generates a slot flow force when hydraulic fluid flows therethrough. The flow slot may be configured so that a predetermined fluid low rate may generate a slot flow force sufficient to actuate the valve element from a first position to a second position. In the second position, the valve element may divert a portion of flow from the second port to the first port is diverted to the third port. The flow slot may be configured so that the fluid exits the slot at an exit angle that varies as the valve element moves between first and second positions, thereby to provide a more uniform flow force across the range of travel of the valve element.

Abstract: The present invention provides a host cell suitable for enhanced production of a protein product of choice characterised in that the host cell is genetically modified to cause over-expression of two or more helper proteins selected from a DnaJ-like protein (such as JEM1), an Hsp70 family protein (such as LHS1) and SIL1, wherein at least one of the over-expressed two or more helper proteins is selected from JEM1, LHS1 and SIL1, and wherein the DnaJ-like protein is not SCJ1.

Abstract: A hydraulic system for a mobile machine having an implement is disclosed. The hydraulic system may have a hydraulic actuator configured to move the implement, a storage device configured to store pressurized fluid, and a valve operable to fluidly communicate the storage device with the hydraulic actuator. The hydraulic system may also have a sensor associated with the mobile machine to generate a signal indicative of a speed of the mobile machine, and a controller in communication with the valve and the sensor. The controller may be configured to compare the speed of the mobile machine to a setpoint and to determine an amount of time elapsed while the speed of the mobile machine exceeds the setpoint. The controller may further be configured to selectively operate the valve to fluidly communicate the storage device with the actuator based on the elapsed amount of time and the speed to cushion movement of the implement.

Abstract: The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.

Abstract: Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.

Abstract: A hydraulic system for a machine is disclosed. The hydraulic system has a source of pressurized fluid, a fluid actuator, and a tank. The hydraulic system utilizes a directional control valve to direct flow between the source, the actuator, and the tank. The hydraulic further utilizes a variable backpressure control valve to control the system backpressure.

Abstract: The present invention provides a host cell suitable for enhanced production of a protein product of choice characterised in that the host cell is genetically modified to cause over-expression of two or more helper proteins selected from a DnaJ-like protein (such as JEM1), an Hsp70 family protein (such as LHS1) and SIL1 wherein at least one of the over-expressed two or more helper proteins is selected from JEM1, LHS1 and SIL1, and wherein the DnaJ-like protein is not SCJ1.

Abstract: A wind turbine rotor blade is provided. The rotor blade comprises a root portion located in a proximal region of the rotor blade and a tip portion connected to the root portion and located in a distal region of the rotor blade. A spar extends from the root portion to the tip portion. The spar is a unitary member at the root portion and separates into a primary spar and a sub-spar towards the tip region of the rotor blade. Each spar and sub-spar has a respective lifting surface of the rotor blade associated therewith, each lifting surface being distinct from each other lifting surface.

Abstract: The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment vocal cord tissue following introduction (e.g. via injection, transplantation, or implantation) into the vocal cords. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, vocal cords in the treatment of various cosmetic or functional conditions, including vocal cord tissue weakness, voice and swallowing disorders. The invention also relates to the novel use of MDCs for the increase of vocal cord tissue mass in speakers, singers or other people in need of greater than average vocal cord tissue mass.

Abstract: The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.

Abstract: A hydraulic system for a mobile machine having an implement is disclosed. The hydraulic system may have a hydraulic actuator configured to move the implement, a storage device configured to store pressurized fluid, and a valve operable to fluidly communicate the storage device with the hydraulic actuator. The hydraulic system may also have a sensor associated with the mobile machine to generate a signal indicative of a speed of the mobile machine, and a controller in communication with the valve and the sensor. The controller may be configured to compare the speed of the mobile machine to a setpoint and to determine an amount of time elapsed while the speed of the mobile machine exceeds the setpoint. The controller may further be configured to selectively operate the valve to fluidly communicate the storage device with the actuator based on the elapsed amount of time and the speed to cushion movement of the implement.

Abstract: The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.