Patents by Inventor Thomas Prisinzano

Thomas Prisinzano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PTPRD inhibitors and uses thereof
    Patent number: 11987564
    Abstract: Disclosed are small molecule PTPRD inhibitors and uses thereof. Methods of using the PTPRD inhibitors include methods of treating, preventing, or delaying the progression of a disorder responsive to PTPRD inhibition, including for example nicotine dependence, addiction, obesity, metabolic syndrome, and substance-use disorders such as stimulant-use disorders and opioid-use disorders.
    Type: Grant
    Filed: May 2, 2022
    Date of Patent: May 21, 2024
    Assignees: Arizona Board of Regents on Behalf of the University of Arizona, The United States Government as respresented by the Department of Veterans Affairs, The University of Kentucky Research Foundation
    Inventors: George Richard Uhl, Ian M. Henderson, Wei Wang, Thomas Prisinzano
  • PTPRD INHIBITORS AND USES THEREOF
    Publication number: 20220380332
    Abstract: Disclosed are small molecule PTPRD inhibitors and uses thereof. Methods of using the PTPRD inhibitors include methods of treating, preventing, or delaying the progression of a disorder responsive to PTPRD inhibition, including for example nicotine dependence, addiction, obesity, metabolic syndrome, and substance-use disorders such as stimulant-use disorders and opioid-use disorders.
    Type: Application
    Filed: May 2, 2022
    Publication date: December 1, 2022
    Inventors: George Richard Uhl, Ian M. Henderson, Wei Wang, Thomas Prisinzano
  • Antagonists of the kappa opioid receptor
    Patent number: 10829453
    Abstract: The present technology is directed to compounds, compositions, and methods related to non-morphinan-like kappa opioid receptor (KOR) antagonists. The technology is suited to treat addiction, diuresis, depression, post traumatic stress disorder, an eating disorder, panic disorder, social anxiety disorder, general anxiety disorder, obsessive compulsive disorders, excessive or unreasonable specific phobias, and/or other conditions related to anxiety or aversion-reward responses.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: November 10, 2020
    Assignees: University of Kansas, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Jeffrey Aube, Kevin Frankowski, Thomas Prisinzano, Laura Bohn
  • ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR
    Publication number: 20190300486
    Abstract: The present technology is directed to compounds, compositions, and methods related to non-morphinan-like kappa opioid receptor (KOR) antagonists. The technology is suited to treat addiction, diuresis, depression, post traumatic stress disorder, an eating disorder, panic disorder, social anxiety disorder, general anxiety disorder, obsessive compulsive disorders, excessive or unreasonable specific phobias, and/or other conditions related to anxiety or aversion-reward responses.
    Type: Application
    Filed: November 2, 2018
    Publication date: October 3, 2019
    Inventors: Jeffrey Aube, Kevin Frankowski, Thomas Prisinzano, Laura Bohn
  • Antagonists of the kappa opioid receptor
    Patent number: 10118896
    Abstract: The present technology is directed to compounds, compositions, and methods related to non-morphinan-like kappa opioid receptor (KOR) antagonists. The technology is suited to treat addiction, diuresis, depression, post traumatic stress disorder, an eating disorder, panic disorder, social anxiety disorder, general anxiety disorder, obsessive compulsive disorders, excessive or unreasonable specific phobias, and/or other conditions related to anxiety or aversion-reward responses.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: November 6, 2018
    Assignees: UNIVERSITY OF KANSAS, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Jeffrey Aube, Kevin Frankowski, Thomas Prisinzano, Laura Bohn
  • ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR
    Publication number: 20170260141
    Abstract: The present technology is directed to compounds, compositions, and methods related to non-morphinan-like kappa opioid receptor (KOR) antagonists. The technology is suited to treat addiction, diuresis, depression, post traumatic stress disorder, an eating disorder, panic disorder, social anxiety disorder, general anxiety disorder, obsessive compulsive disorders, excessive or unreasonable specific phobias, and/or other conditions related to anxiety or aversion-reward responses.
    Type: Application
    Filed: November 25, 2015
    Publication date: September 14, 2017
    Inventors: Jeffrey Aube, Kevin Frankowski, Thomas Prisinzano, Laura Bohn
  • Therapeutic compounds
    Patent number: 9428494
    Abstract: The invention provides novel compounds of formula I: that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. Compounds of the invention are useful to modulate (e.g. agonize or antagonize) opioid receptor function.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: August 30, 2016
    Assignee: University of Iowa Research Foundation
    Inventor: Thomas Prisinzano
  • THERAPEUTIC COMPOUNDS
    Publication number: 20100179217
    Abstract: The invention provides novel compounds of formula I: that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. Compounds of the invention are useful to modulate (e.g. agonize or antagonize) opioid receptor function.
    Type: Application
    Filed: November 2, 2007
    Publication date: July 15, 2010
    Applicant: University of Iowa Research Foundation
    Inventor: Thomas Prisinzano
  • Opioid receptor ligands and methods for their preparation
    Patent number: 7728001
    Abstract: The invention provides novel compounds of formula I: that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. The invention also provides an improved method for isolating intermediate materials useful for obtaining compounds of formula I.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: June 1, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: Thomas Prisinzano, Richard Brian Rothman
  • Opioid receptor ligands and methods for their preparation
    Publication number: 20060058264
    Abstract: The invention provides novel compounds of formula I: that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. The invention also provides an improved method for isolating intermediate materials useful for obtaining compounds of formula I.
    Type: Application
    Filed: September 12, 2005
    Publication date: March 16, 2006
    Inventor: Thomas Prisinzano