Abstract: A pharmaceutical composition, a combination product including the composition and a method of manufacturing the composition. The composition includes a particulate complex of API bound with a crosslinked polysaccharide micro sponge. The combination product includes a dosage form of the particulate complex within a container. The amount of the particulate complex is selected to provide a defined dose of the API. The formulation may be heated within the container by a vaporizer device, vaporizing the API and dissociating the API from the micro sponge as vapour, which passes through apertures in the container facilitating administration of the API by inhalation of the vapour. The apertures are sized to facilitate passage of the vapour but prevent passage the particulate complex. The API may be hydrophobic such as phytocannabinoids or hydrophilic such as nicotine. The pharmaceutical composition may be manufactured by driving binding of the API to the micro sponge in solution.

Abstract: A substrate is brought into close proximity with one or more gas injectors to deposit a thin film. As the substrate is moved horizontally along a predefined direction, it is injected with reactive gases and pyrolytically heated with a heating light focused on the substrate. To prevent photolytic reactions, the heating light source is preferably on the side of the substrate opposite to the side where the reactive gases are deposited. In some embodiments, this heating light source is supplemented by heating light sources on the same side of the substrate as the deposited reactive gases. The heating light source(s) has a wavelength to optimize absorption by the substrate or the deposited film layer.