Patents by Inventor Thomas R. Pyke

Thomas R. Pyke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mycobacterium fortuitum mutant
    Patent number: 4345033
    Abstract: Mutant which is used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to yield predominantly androst-4-ene-3,17-dione (AD) and small amounts of androsta-1,4-diene-3,17-dione (ADD). AD is a valuable intermediate to make useful steroids.
    Type: Grant
    Filed: September 8, 1980
    Date of Patent: August 17, 1982
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Candice B. Biggs, Thomas R. Pyke
  • Biologically pure culture of mutant mycobacterium
    Patent number: 4339539
    Abstract: Mutants which are used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione (AD). ADD and AD are valuable intermediates to make useful steroids.
    Type: Grant
    Filed: September 8, 1980
    Date of Patent: July 13, 1982
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Candice B. Biggs, Thomas R. Pyke
  • Mycobacterium fortuitum strain
    Patent number: 4328315
    Abstract: Mutants which are used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione (AD). ADD and AD are valuable intermediates to make useful steroids.
    Type: Grant
    Filed: September 8, 1980
    Date of Patent: May 4, 1982
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Candice B. Biggs, Thomas R. Pyke
  • Process for preparing androsta-1,4-diene-3,17-dione and androst-4-ene-3,17-dione
    Patent number: 4293645
    Abstract: Mutants which are used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione (AD). ADD and AD are valuable intermediates to make useful steroids.
    Type: Grant
    Filed: November 9, 1977
    Date of Patent: October 6, 1981
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Candice B. Biggs, Thomas R. Pyke
  • Process for microbial transformation of steroids
    Patent number: 4211841
    Abstract: Novel microbial transformation process to selectively convert steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to 3a.alpha.-H-4.alpha.-[3'-propionic acid]-7a.beta.-methylhexahydro-1,5-indanedione having the following structure: ##STR1## This compound can be used as an intermediate to make useful 19-nor steroids.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: July 8, 1980
    Assignee: The Upjohn Company
    Inventors: Candice B. Biggs, Thomas R. Pyke, Merle G. Wovcha
  • Process for preparing 3a.alpha.-H-4.alpha.-[3'-propanol]-7a.beta.-methylhexahydro-1,5-indanedi one hemiketal
    Patent number: 4177106
    Abstract: Novel microbial transformation process to selectively convert steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to 3a.alpha.-H-4.alpha.-[3'-propanol]-7a.beta.-methylhexahydro-1,5-indaned ione hemiketal having the following structure: ##STR1## This compound can be used as an intermediate to make useful 19-nor steroids.
    Type: Grant
    Filed: February 21, 1978
    Date of Patent: December 4, 1979
    Assignee: The Upjohn Company
    Inventors: Thomas R. Pyke, Marion P. Salmond
  • Microbial transformation of steroids
    Patent number: 4097335
    Abstract: Novel microbial transformation process to selectively convert steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to 3a.alpha.-H-4.alpha.-?3'-propanol!-7a.beta.-methylhexahydro-1,5-indaned ione hemiketal having the following structure: ##STR1## This compound can be used as an intermediate to make useful 19-nor steroids.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: June 27, 1978
    Assignee: The Upjohn Company
    Inventors: Thomas R. Pyke, Marion P. Salmond
  • Microbial transformation of steroids
    Patent number: 4062729
    Abstract: Novel microbial transformation process to selectively convert steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to 3a.alpha.-H-4.alpha.-[3'-propionic acid]-7a.beta.-methylhexahydro-1,5-indanedione having the following structure: ##STR1## This compound can be used as an intermediate to make useful 19-nor steroids.
    Type: Grant
    Filed: November 26, 1976
    Date of Patent: December 13, 1977
    Assignee: The Upjohn Company
    Inventors: Candice B. Biggs, Thomas R. Pyke, Merle G. Wovcha