Abstract: The present invention provides cross-linking compounds having structures as set forth herein for cross-linking organic polymers. Further, polymer compositions include a cross-linking compound and an organic polymer, and in some embodiments the composition further includes a cross-linking reaction additive for controlling the cross-linking reaction rate. In alternate embodiments, the present invention provides cross-linking compositions including a cross-linking compound and a cross-linking reaction additive capable of forming a reactive intermediate oligomer for cross-linking an organic polymer. Further provided are methods of cross-linking organic polymers, organic polymers formed thereby, and molded articles formed from the cross-linked organic polymers. Additionally, methods for forming high glass transition temperature elastomeric materials and methods for forming extrusion-resistant and creep-resistant materials are provided.

Abstract: The present invention is directed to substituted azetidine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Abstract: The present invention is directed to substituted triazolyl compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Abstract: The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative ?-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.

Abstract: The present invention is directed to substituted azetidinecompounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Abstract: The present invention is directed to substituted triazolyl compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Abstract: The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative ?-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.

Abstract: Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of inflammatory bowel disease including ulcerative colitis and Crohn's disease, multiple sclerosis, asthma, and rheumatoid arthritis.

Abstract: Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, drug addiction, drug abuse, drug withdrawal, obesity and other diseases.

Abstract: The present invention encompasses compounds of Formula I or pharmaceutically acceptable salts thereof, wherein each R1 may be substituted at any substitutable position on A and each R1 is independently selected from the group consisting of: halo, cyano, C1-4alkoxy, C1-4alkylthio and C1-4alkyl, each of said C1-4alkoxy, C1-4alkylthio and C1-4alkyl optionally substituted with 1 to 3 halo groups, R2 is selected from the group consisting of: C1-6alkyl and C3-6cycloalkyl, R3 is selected from the group consisting of: hydrogen, C1-6alkyl and C3-6cycloalkyl and R4 is a nitric oxide releasing moiety. Pharmaceutical composition comprising said compounds and methods of using said compounds are also encompassed. The compounds of the present invention lower the level of A?42 and are therefore useful for treating or preventing Alzheimer's Disease. The compounds of the invention also release nitric oxide in vivo and have a reduced potency for cyclooxygenase activity.