Patents by Inventor Thomas Roy Webb

Thomas Roy Webb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
    Patent number: 8629147
    Abstract: The present invention provides compounds capable of modulating tyrosine kinases, compositions comprising the compounds and methods of their use.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: January 14, 2014
    Assignee: ChemBridge Corporation
    Inventors: Alexey Vyacheslavovich Anikin, Vidyasagar Reddy Gantla, Vlad Edward Gregor, Luyong Jiang, Yahua Liu, Danny Peter Claude McGee, Charles Chamchoumis Mikel, Jason Conrad Pickens, Thomas Roy Webb, Zheng Yan, Tong Zhu, Aleksander Kadushkin, Sergey Sviridov, Sergey Zozulya, Alexander Chucholowski, Douglas Eric McGrath
  • Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
    Publication number: 20080207635
    Abstract: The present invention provides compounds capable of modulating tyrosine kinases, compositions comprising the compounds and methods of their use.
    Type: Application
    Filed: November 2, 2006
    Publication date: August 28, 2008
    Inventors: Alexey Vyacheslavovich Anikin, Vidyasagar Reddy Gantla, Vlad Edward Gregor, Luyong Jiang, Yahua Liu, Danny Peter Claude McGee, Charles Chamchoumis Mikel, Jason Conrad Pickens, Thomas Roy Webb, Zheng Yan, Tong Zhu, Aleksander Kadushkin, Sergey Sviridov, Sergey Zozulya, Alexander Chucholowski, Douglas Eric McGrath
  • Inhibitors of thrombosis
    Patent number: 5955576
    Abstract: This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 21, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Thomas Roy Webb, Matthew Mark Abelman, Daniel Andrew Pearson, Todd Anthony Miller
  • Inhibitors of factor Xa
    Patent number: 5883077
    Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The novel compounds include peptide aldehyde analogues having substantial potency and specificity as inhibitors of mammalian factor Xa are further disclosed. The compounds are thought useful as inhibitors of factor xa in vitro or as a therapeutic agent for the prevention and treatment of conditions characterized by abnormal thrombosis in mammals. Intermediates useful for the preparation of the novel compounds are also disclosed.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: March 16, 1999
    Assignee: Corvas International, Inc.
    Inventors: Terence Kevin Brunck, Thomas Roy Webb, William Charles Ripka
  • Arginine keto-amide enzyme inhibitors
    Patent number: 5869454
    Abstract: The present invention is directed to novel arginine alpha-keto-amide derivatives, their pharmaceutically acceptable salts and compositions thereof which are useful as antithrombotic agents in mammals and also the use of these compounds as antithrombotic agents. Also, described are methods of using these inhibitors as inhibitors of coagulation proteases and as therapeutic agents for disease states characterized by abnormal thrombus formation and/or disorders of the blood coagulation process. Further described herein are compounds useful as intermediates in the preparation of these compounds.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 9, 1999
    Assignee: Corvas International, Inc.
    Inventors: Thomas Roy Webb, Todd Anthony Miller, George Phillip Vlasuk, Matthew Mark Abelman
  • Inhibitors of factor Xa
    Patent number: 5739112
    Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The novel compounds include peptide aldehyde analogues having substantial potency and specificity as inhibitors of mammalian factor Xa are further disclosed. The compounds are thought useful as inhibitors of factor Xa in vitro or as a therapeutic agent for the prevention and treatment of conditions: characterized by abnormal thrombosis in mammals. Intermediates useful for the preparation of the novel compounds are also disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 14, 1998
    Assignee: Corvas International, Inc.
    Inventors: Terence Kevin Brunck, Thomas Roy Webb, William Charles Ripka
  • Method of synthesis of peptidyl aldehydes
    Patent number: 5731413
    Abstract: This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to ?novel! reagents useful therein.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 24, 1998
    Assignee: Corvas International, Inc.
    Inventors: Thomas Roy Webb, John Eugene Reiner, Susan Yoshiko Tamura, William Charles Ripka, Raymond Dagnino, Jr., Ruth Foelsche Nutt