Patents by Inventor Thomas S. Dexheimer

Thomas S. Dexheimer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridazinones and their use in the treatment of cancer
    Patent number: 11110089
    Abstract: There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein W, X, Y, Z, R1, R2 and R3 have meanings provided in the description, which compounds are useful in the treatment of cancers.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: September 7, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Elias Set Jenö Arnér
    Inventors: Elias Set Jenö Arnér, William Chester Stafford, Nathan Patrick Coussens, Diane Karen Luci, David Joseph Maloney, Anton Simeonov, Ajit Jadhav, Thomas S. Dexheimer
  • Pyridines and their use in the treatment of cancer
    Patent number: 10899710
    Abstract: There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3, R4 and n have meanings provided in the description, which compounds are useful in the treatment of cancers.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: January 26, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Elias Set Jenö Arnér, William Chester Stafford, Nathan Patrick Coussens, Diane Karen Luci, David Joseph Maloney, Anton Simeonov, Ajit Jadhav, Thomas S. Dexheimer
  • Tricyclic compounds and their use in the treatment of cancer
    Patent number: 10881653
    Abstract: There is provided compounds of formula (I), or pharmaceutically-acceptable salts thereof, wherein X, Y, Z, R1 and R2 have meanings provided in the description, which compounds are useful in the treatment of cancers.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: January 5, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Elias Set Jenö Arnér, William Chester Stafford, Nathan Patrick Coussens, Diane Karen Luci, David Joseph Maloney, Anton Simeonov, Ajit Jadhav, Thomas S. Dexheimer
  • PYRIDAZINONES AND THEIR USE IN THE TREATMENT OF CANCER
    Publication number: 20200113897
    Abstract: There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein W, X, Y, Z, R1, R2 and R3 have meanings provided in the description, which compounds are useful in the treatment of cancers.
    Type: Application
    Filed: August 5, 2016
    Publication date: April 16, 2020
    Inventors: Elias Set Jenö Arnér, William Chester Stafford, Nathan Patrick Coussens, Diane Karen Luci, David Joseph Maloney, Anton Simeonov, Ajit Jadhav, Thomas S. Dexheimer
  • TRICYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER
    Publication number: 20200113889
    Abstract: There is provided compounds of formula (I), or pharmaceutically-acceptable salts thereof, wherein X, Y, Z, R1 and R2 have meanings provided in the description, which compounds are useful in the treatment of cancers.
    Type: Application
    Filed: August 5, 2016
    Publication date: April 16, 2020
    Inventors: Elias Set Jenö Arnér, William Chester Stafford, Nathan Patrick Coussens, Diane Karen Luci, David Joseph Maloney, Anton Simeonov, Ajit Jadhav, Thomas S. Dexheimer
  • PYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER
    Publication number: 20200087260
    Abstract: There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3, R4 and n have meanings provided in the description, which compounds are useful in the treatment of cancers.
    Type: Application
    Filed: August 5, 2016
    Publication date: March 19, 2020
    Applicant: The USA, as Represented by the Secretary, Department pf Health and Human Services
    Inventors: Elias Set Jenö ARNÉR, William Chester STAFFORD, Nathan Patrick COUSSENS, Diane Karen LUCI, Davvid Joseph MALONEY, Anton SIMEONOV, Ajit JADHAV, Thomas S. DEXHEIMER
  • Inhibitors of the USP1/UAF1 deubiquitinase complex and uses thereof
    Patent number: 9802904
    Abstract: Disclosed are inhibitors of the USP1/UAF1 deubiquitinase complex, for example. of formula (I), wherein R1, R2, and Q are as defined herein, which are useful in treating diseases such as cancer, and improving the efficacy of DNA damaging agents in cancer treatment. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a heterodimeric deubiquitinase complex in a cell, and a method of enhancing the chemotherapeutic treatment of cancer in a mammal undergoing treatment with an anti cancer agent. Further disclosed is a method of preparing compounds of the invention.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: October 31, 2017
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Delaware
    Inventors: David J. Maloney, Andrew S. Rosenthal, Ajit Jadhav, Thomas S. Dexheimer, Anton Simeonov, Zhihao Zhuang, Qin Liang, Diane K. Luci
  • INHIBITORS OF THE USP1/UAF1 DEUBIQUITINASE COMPLEX AND USES THEREOF
    Publication number: 20150344443
    Abstract: Disclosed are inhibitors of the USP1/UAF1 deubiquitinase complex, for example. of formula (I), wherein R1, R2, and Q are as defined herein, which are useful in treating diseases such as cancer, and improving the efficacy of DNA damaging agents in cancer treatment. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a heterodimeric deubiquitinase complex in a cell, and a method of enhancing the chemotherapeutic treatment of cancer in a mammal undergoing treatment with an anti cancer agent. Further disclosed is a method of preparing compounds of the invention.
    Type: Application
    Filed: December 26, 2013
    Publication date: December 3, 2015
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human, University of Delaware
    Inventors: David J. Maloney, Andrew S. Rosenthal, Ajit Jadhav, Thomas S. Dexheimer, Anton Simeonov, Zhihao Zhuang, Qin Liang, Diane K. Luci