Patents by Inventor Thomas Scott Wehrman

Thomas Scott Wehrman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biological encoding of large numbers of cells
    Patent number: 8999652
    Abstract: Mixtures of cell types can be analyzed by having at least two signal markers, with at least one at three different levels to provide a barcode for each cell type. The mixture of cells may be subjected to a common candidate moiety and the effect of the moiety on the cells determined along with identification of the cell by the barcode. Conveniently, surface marker proteins and labeled antibodies can be used to create the barcode and the cells analyzed with flow cytometry.
    Type: Grant
    Filed: August 5, 2008
    Date of Patent: April 7, 2015
    Assignee: Primity Bio, Inc.
    Inventors: Peter Oliver Krutzik, Thomas Scott Wehrman
  • ?-galactosidase donor fragments
    Patent number: 8101373
    Abstract: Truncated fragments of the small fragment of ?-galactosidase are provided that have low affinity for the large fragment of ?-galactosidase and provide for robust signals when two fusion proteins are complexed due to the binding of the proteins to which the ?-galactosidase fragments are fused. The truncated fragments do not interfere with the complexing of the two proteins and allow for the two proteins to function and be responsive to candidate compounds that affect complex formation.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: January 24, 2012
    Assignee: Discoverx Corporation
    Inventors: Thomas Scott Wehrman, Keith R. Olson
  • BIOLOGICAL ENCODING OF LARGE NUMBERS OF CELLS
    Publication number: 20100203543
    Abstract: Mixtures of cell types can be analyzed by having at least two signal markers, with at least one at three different levels to provide a barcode for each cell type. The mixture of cells may be subjected to a common candidate moiety and the effect of the moiety on the cells determined along with identification of the cell by the barcode. Conveniently, surface marker proteins and labeled antibodies can be used to create the barcode and the cells analyzed with flow cytometry.
    Type: Application
    Filed: August 5, 2008
    Publication date: August 12, 2010
    Inventors: Peter Oliver Krutzik, Thomas Scott Wehrman
  • BETA GALACTOSIDASE DONOR FRAGMENTS
    Publication number: 20090098588
    Abstract: Truncated fragments of the small fragment of ?-galactosidase are provided that have low affinity for the large fragment of ?-galactosidase and provide for robust signals when two fusion proteins are complexed due to the binding of the proteins to which the ?-galactosidase fragments are fused. The truncated fragments do not interfere with the complexing of the two proteins and allow for the two proteins to function and be responsive to candidate compounds that affect complex formation.
    Type: Application
    Filed: October 10, 2008
    Publication date: April 16, 2009
    Applicant: DiscoveRx Corporation
    Inventors: Thomas Scott Wehrman, Keith R. Olson