Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: The present invention generally relates to the field of conformance control in oil fields, particularly to a re-crosslinkable preformed particle gel system, and composition thereof. The composition of the re-crosslinkable preformed particle gel system contains monomers, crosslinkers, a polymer matrix, and additives. Components in the composition for re-crosslinkable preformed particle gel in the present invention have excellent compatibility with each other, and the obtained gel has excellent long term high-temperature resistance property. Different from prior products, in the re-crosslinkable preformed particle gel compositions according to embodiments of the present invention, the components that are used to re-crosslink the particle gels may be grafted on the polymer chain and will act as initiator or secondary crosslinker in different conditions. During particle injection process, all compositions would move together, thereby avoiding chromatographic problems typical of prior products.

Abstract: The instant disclosure relates to methods for preventing, controlling and/or inhibiting the rare events of adventitious viral infection or viral replication/amplification after reactivation of latent viral infection during cell culture in the manufacturing process of cell-based drug products, including CAR T cell drug products. Also provided are in vitro cell culture models for HHV-6 latent infection and methods of making the same.

Abstract: An apparatus and method of signaling coding type is disclosed. The coding types include binary convolutional coding (BCC), legacy lifted Low-Density Parity Check (LDPC) code, and lifted LDPC code having a length that is a multiple of the maximum legacy LDPC code. The number of bits used to indicate the coding type in a User Info field depends on whether multiple lifted LDPC codes are available for encoding, whether the lifted LDPC code is an optional coding type, or a payload size. The frame containing the User Info field is transmitted to another STA and the response contains a payload encoded using the indicated coding type.

Abstract: Example methods, systems, and apparatuses for verifying a printed indicium are provided. An example method may include receiving a captured image of a print media comprising the printed indicium; extracting a quiet zone grade portion from the captured image, where the quiet zone grade portion includes a printed indicium area of the printed indicium and at least one quiet zone area adjacent to the printed indicium area; in response to receiving a user input providing an overwrite quiet zone requirement indication and determining that the at least one quiet zone area does not satisfy at least one quiet zone requirement, causing at least one of adjusting the at least one quiet zone requirement to at least one reduced quiet zone requirement or adding at least one additional quiet zone area to the at least one quiet zone area.

Abstract: Embodiments include a footwear device for controlling an electronic device, the footwear device including a toe portion, a heel portion, and a sole portion defined along a bottom portion of the footwear device between the toe and heel portion. The device further including one or more sensors incorporated with the sole portion and configured to detect a movement of the footwear device. The device further includes a controller configured to store a footwear action database comprising footwear actions respectively assigned to input control actions of the electronic device. receive the output signal of the sensors, identify a corresponding input control action using the footwear action database, and generate a control signal based on the input control action. The device further includes a communication module to transmit a control signal to a game controller such that the movement of the footwear device causes the input control action of the electronic device.

Abstract: Method and apparatus for monitoring, controlling and adjusting sleeper's environmental conditions of the space above entire bed surface by partially sealing and insulating the space above the entire bed surface; monitoring, controlling and adjusting temperature, quality, oxygen level and moisture level of the air within the partially sealed and insulated space according combinational factors of the sleeper's preferences, the sleeper's physiological conditions, heat transfer rate between sleeper's body and ambient air, the internal conditions and external conditions of the partially sealed and insulated space.