Abstract: The invention relates, for example, to methods for preparing a plant or animal sample for processing, i.e. for example for the isolation of nucleic acids or proteins from the sample, as well as to a pulverizer.

Abstract: The invention relates to metallic paint comprising water and/or organic solvent and also at least one film-forming agent, at least one organofunctional silane, and at least one metallic effect pigment, the metallic effect pigment being a leafing aluminum pigment. The invention also relates to a process for preparing the metallic paint of the invention, and its use. Also, furthermore, an article painted with the metallic paint of the invention, and a vehicle finish.

Abstract: The invention relates, for example, to methods for preparing a plant or animal sample for processing, i.e. for example for the isolation of nucleic acids or proteins from the sample, as well as to a pulverizer.

Abstract: The invention relates to methods for the treatment of Duchenne muscular dystrophy and to methods for determining the prognosis of a subject affected with Duchenne Muscular Dystrophy. More particularly, the present invention relates to a VLA-4 antagonist for use in the treatment of Duchenne Muscular Dystrophy. The present invention also relates to a method for determining the prognosis of a subject affected with Duchenne Muscular Dystrophy wherein said method comprising a step consisting of determining the level of VLA-4 high T cells in a blood sample obtained from said subject.

Abstract: Methods for stabilizing unstable proteins or for restoring functionality to non-functional or poorly functioning (semi-functional) proteins using exon skipping technology are provided. The methods involve the administration of antisense oligonucleotides to cause exon skipping, thereby removing one or more exons responsible for protein instability or lack of functionality. For example, exons encoding protease recognition sites may be removed. The method is useful for treating diseases caused by protein instability, such as Becker Muscular Dystrophy, or for treating Duchenne Muscular Distrophy patients with semi-functional dystrophin due to treatment with other exon skipping or stop codon readthrough therapies.

Abstract: Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stem-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA.

Abstract: The invention relates to a storage and dispensing vessel for microsystems and to a method for storing and dispensing a liquid. It is the object of the invention to be able to store a liquid with volatile and/or creeping substances in very small vessels over many months, preferably over at least one year, and to be able to dispense it automatically with comparatively little technical effort. For accomplishing this object, a bellows configured as a vessel is provided which is sealed, preferably welded, in an air-tight and liquid-tight manner once the bellows vessel has been filled. This bellows vessel at the same time serves as a dispensing vessel. The vessel can be emptied automatically with relatively simple means. For this purpose, it is, for example, clamped into a device which compresses the bellows, namely in the direction of a hollow needle—also referred to as cannula or hypodermic needle—or of a comparable means. In the process, the hollow needle or the comparable means pierces a vessel wall.

Abstract: A system (10) for removing a pipettable substance from a pre-filled container (20), which is closed off by a top (30) having at least one opening area (40), comprises an opening tool (100) having a tube (110), which has a cross-section corresponding substantially to the shape of the opening area and which comprises at a distal end (120) an endpiece (140) extending substantially obliquely relative to the longitudinal axis of the tube, which moves a part of the top (30) located inside the opening area (40) towards the container when the opening tool is applied, so as to form an opening in the top, and a point of attack (150) for a transporting tool (200). The opening tool (100) is designed to remain on the container (20) after use.

Abstract: A system (10) for removing a pipettable substance from a pre-filled container (20), which is closed off by a top (30) having at least one opening area (40), comprises an opening tool (100) having a tube (110), which has a cross-section corresponding substantially to the shape of the opening area and which comprises at a distal end (120) an endpiece (140) extending substantially obliquely relative to the longitudinal axis of the tube, which moves a part of the top (30) located inside the opening area (40) towards the container when the opening tool is applied, so as to form an opening in the top, and a point of attack (150) for a transporting tool (200). The opening tool (100) is designed to remain on the container (20) after use.

Abstract: A gripper unit for handling a vessel for receiving biological material is proposed, inter alia. The vessel has a lid which can assume an open position and a closed position. The gripper unit comprises a gripper for gripping and releasing the vessel, and a lid holder, for holding a lid in a defined position in relation to the vessel. The defined position is an open position of the lid.

Abstract: The invention relates to metallic paint comprising water and/or organic solvent and also at least one film-forming agent, at least one organofunctional silane, and at least one metallic effect pigment, the metallic effect pigment being a leafing aluminum pigment. The invention also relates to a process for preparing the metallic paint of the invention, and its use. Also, furthermore, an article painted with the metallic paint of the invention, and a vehicle finish.

Abstract: The present invention relates to improved methods for processing fluids and to a fluid processing device (1) for use in a centrifuge comprising: (a) a first holder (14) form-fit to the shape of a first tube (18) for holding said first tube (18) whereby said first tube (18) has a first cross section (A1); and (b) a second holder (22) form-fit to the shape of a second tube (26) for holding said second tube (26) whereby said second tube (26) has a second cross section (A2) that is different from said first cross section (A1). With the fluid processing devices and the methods according to the invention, it is possible to simplify the centrifugal processing steps for a given fluid processing sequence and to automate them.

Abstract: A two-component anticorrosion paint comprising metal pigment, epoxy binder component and amine curing agent and containing two components A and B, of which Component A comprises (a1) (x?y)% by weight of metal pigments comprising platelet-type zinc containing metal pigments, where x is 30 to 70, (a2) from 10 to 50% by weight of at least one epoxysilane and/or epoxy silicone, and (a3) from 0 to 40% by weight of an organic solvent, and Component B comprises (b1) from 2 to 15% by weight of at least one amine curing agent, (b2) y % by weight of metal pigments comprising platelet-type zinc-containing metal pigments, where y is from 0 to x % by weight, (b3) from 0 to 40% by weight of an organic solvent, the percentages being based on the total weight of the two-component anticorrosion paint and total 100% by weight, with the proviso that the total water content of the two-component anticorrosion paint is not more than 5% by weight, the total content of solvent is not more than 40% by weight, and the total cont

Abstract: The invention relates to a cosmetic composition comprising a liquid phase and a PVD aluminum pigment, wherein the cosmetic composition contains a PVD aluminum pigment at a pigmentation level of from 0.05 to 5.0% by weight, based on the total weight of the cosmetic composition, and at least one leafing additive. The invention further relates to an artificial fingernail and to the use of a PVD aluminum pigment.