Patents by Inventor Thomas W. Gero

Thomas W. Gero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rilyazine derivatives and compositions for the treatment of cancer
    Patent number: 9394299
    Abstract: The present application discloses Rilyazine analogs, methods for their preparation, and the treatment of cancer by the administration of an effective amount of the Rilyazine analogs to a patient in need thereof.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: July 19, 2016
    Assignee: Warner Babcock Institute for Green Chemistry, LLC
    Inventors: John C. Warner, Jeffery A. Gladding, Thomas W. Gero, Srinivasa R. Cheruku
  • Rilyazine Derivatives and Compositions for The Treatment of Cancer
    Publication number: 20150065510
    Abstract: The present application discloses Rilyazine analogs, methods for their preparation, and the treatment of cancer by the administration of an effective amount of the Rilyazine analogs to a patient in need thereof.
    Type: Application
    Filed: August 29, 2014
    Publication date: March 5, 2015
    Applicant: Warner Babcock Institute For Green Chemistry, LLC
    Inventors: John C. Warner, Jeffery A. Gladding, Thomas W. Gero, Srinivasa R. Cheruku
  • 2-(2-substituted aminoethyl)-1,4-dialkyl-3,4-dihydro-1H-1,3,5]triazepino[3,2-a]benzimidaz ol-5(2H)-ones as muscle relaxants
    Patent number: 5109013
    Abstract: Novel compounds of the formula: ##STR1## wherein R and R.sup.1 are C.sub.1 -C.sub.6 alkyl or cycloalkyl and R.sup.2 and R.sup.3 are independently selected from C.sub.1 -C.sub.6 alkyl or aryl or --NR.sup.2 R.sup.3 forms a heterocyclic group which may be further substituted are disclosed. These compounds were found to possess muscle relaxant properties.
    Type: Grant
    Filed: June 6, 1990
    Date of Patent: April 28, 1992
    Assignee: A. H. Robins Company, Incorporated
    Inventors: Albert D. Cale, Jr., Thomas W. Gero
  • N-(1-methyl-3-pyrrolidinyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine and analogs as antiarrhythmic and muscle relaxing agents
    Patent number: 5106857
    Abstract: A method of treating cardiac arrhythmias and muscle tension and spasticity with N-(1-methyl-3-pyrrolidinyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine and analogs and the pharmaceutical compositions are herein disclosed. Illustratively, the compound having the structure: ##STR1## corrects an induced arrhythmia in 7 out of 8 dogs at 7 mg/kg IV and has an ED.sub.50 of 21 mg/kg in the mouse Straub-tail test.
    Type: Grant
    Filed: May 9, 1991
    Date of Patent: April 21, 1992
    Assignee: A. H. Robins Company, Incorporated
    Inventors: Albert D. Cale, Jr., Thomas W. Gero
  • 4-(substitutedaminoethy l)-3,4-dihydro-2-alkylpyrimido[1,6-a]benzimidazol-1(2H)-ones as antiarrhythmic agents
    Patent number: 5063228
    Abstract: Novel compounds of the formula: ##STR1## Where R.sup.1 is loweralkyl and R.sup.2 and R.sup.3 are independently H, loweralkyl, aryl, or--NR.sup.2 R.sup.3 forms a heterocyclic group such as imidazole, morpholine, piperidine, or piperazine were found to exhibit cardiac arrhythmia correcting properties.
    Type: Grant
    Filed: May 31, 1990
    Date of Patent: November 5, 1991
    Assignee: A. H. Robbins Company, Incorporated
    Inventors: Albert D. Cale, Jr., Thomas W. Gero