Patents by Inventor Thomas W. Stief

Thomas W. Stief has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7741124
    Abstract: Described are determination procedures for fibrinogen and/or fibrinogen-derivatives by matrix-independent turbidimetry. In the FIFTA called procedure the fibrinogen activity is preferably determined in an undiluted sample by addition of thrombin and/or albumin, as well as polybrene if appropriate, in PBS and determination of the increase in absorbance at 405 nm. In the FIATA called procedure the fibrinogen-concentration and/or the concentration of fibrinogen-derivatives is preferably determined by addition of vancomycin and determination of the increase in turbidity at 405 nm. It is standardized by usage of plasma standards of known fibrinogen-activity and/or fibrinogen-concentration.
    Type: Grant
    Filed: January 13, 2009
    Date of Patent: June 22, 2010
    Inventor: Thomas W. Stief
  • Patent number: 7723058
    Abstract: The present invention describes a test system for the determination of in-vivo active hemostasis proteases in biological fluids and the use thereof to determine the in-vivo activation of hemostasis or to diagnose pancreatitis. EDTA and/or EGTA is added to the biological sample to prevent artificial activation of the hemostasis proteases. Arginine and/or guanidine can also be added to the biological sample.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: May 25, 2010
    Inventor: Thomas W. Stief
  • Publication number: 20090176310
    Abstract: Described are determination procedures for fibrinogen and/or fibrinogen-derivatives by matrix-independent turbidimetry. In the FIFTA called procedure the fibrinogen activity is preferably determined in an undiluted sample by addition of thrombin and/or albumin, as well as polybrene if appropriate, in PBS and determination of the increase in absorbance at 405 nm. In the FIATA called procedure the fibrinogen-concentration and/or the concentration of fibrinogen-derivatives is preferably determined by addition of vancomycin and determination of the increase in turbidity at 405 nm. It is standardized by usage of plasma standards of known fibrinogen-activity and/or fibrinogen-concentration.
    Type: Application
    Filed: January 13, 2009
    Publication date: July 9, 2009
    Inventor: Thomas W. Stief
  • Patent number: 7510879
    Abstract: Described are determination procedures for fibrinogen and/or fibrinogen-derivatives by matrix-independent turbidimetry. In the FIFTA called procedure the fibrinogen activity is preferably determined in an undiluted sample by addition of thrombin and/or albumin, as well as polybrene if appropriate, in PBS and determination of the increase in absorbance at 405 nm. In the FIATA called procedure the fibrinogen-concentration and/or the concentration of fibrinogen-derivatives is preferably determined by addition of vancomycin and determination of the increase in turbidity at 405 nm. It is standardized by usage of plasma standards of known fibrinogen-activity and/or fibrinogen-concentration.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: March 31, 2009
    Inventor: Thomas W. Stief
  • Patent number: 7192697
    Abstract: A modified limulus test procedure is provided to measure the lipopolysaccharide (LPS), lipid A, and/or glucan reactivity in a biological liquid. The test procedure is independent of the anti-limulus factors present in the sample. The procedure involves strong oxidative treatment of the biological liquid sample.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: March 20, 2007
    Inventor: Thomas W. Stief
  • Patent number: 7135304
    Abstract: Test system for the determination of in-vivo active hemostasis proteases or of trypsin or subtilisin in biological fluids and the usage thereof to determine the in-vivo activation of hemostasis or to diagnose pancreatitis.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: November 14, 2006
    Inventor: Thomas W. Stief
  • Publication number: 20040253739
    Abstract: Described are determination procedures for fibrinogen and/or fibrinogen-derivatives by matrix-independent turbidimetry. In the FIFTA called procedure the fibrinogen activity is preferably determined in an undiluted sample by addition of thrombin and/or albumin, as well as polybrene if appropriate, in PBS and determination of the increase in absorbance at 405 nm. In the FIATA called procedure the fibrinogen-concentration and/or the concentration of fibrinogen-derivatives is preferably determined by addition of vancomycin and determination of the increase in turbidity at 405 nm. It is standardized by usage of plasma standards of known fibrinogen-activity and/or fibrinogen-concentration.
    Type: Application
    Filed: June 2, 2004
    Publication date: December 16, 2004
    Inventor: Thomas W. Stief
  • Publication number: 20030044876
    Abstract: Test system for the determination of in-vivo active hemostasis proteases or of trypsin or subtilisin in biological fluids and the usage thereof to determine the in-vivo activation of hemostasis or to diagnose a pancreatitis.
    Type: Application
    Filed: April 2, 2002
    Publication date: March 6, 2003
    Inventor: Thomas W. Stief