Patents by Inventor Thomas Weller

Thomas Weller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfonylamino-acetic acid derivatives
    Patent number: 7435815
    Abstract: The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: October 14, 2008
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Hamed Aissaoui, Martine Clozel, Walter Fischli, Ralf Koberstein, Thierry Sifferlen, Thomas Weller
  • Novel Tetrahydropyridine Derivatives
    Publication number: 20080234305
    Abstract: The invention relates to novel tetrahydropyridine derivatives and use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
    Type: Application
    Filed: October 5, 2004
    Publication date: September 25, 2008
    Inventors: Olivier Bezencon, Daniel Bur, Walter Fischli, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Thomas Weller
  • 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
    Patent number: 7427613
    Abstract: The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: September 23, 2008
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Olivier Bezencon, Daniel Bur, Walter Fischli, Lubos Remen, Sylvia Richard-Bildstein, Hans-Peter Weber, Thomas Weller
  • Novel Piperidine Carboxylic Acid Amide Derivatives
    Publication number: 20080214598
    Abstract: The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.
    Type: Application
    Filed: May 23, 2006
    Publication date: September 4, 2008
    Applicant: ACTELION PHARMACEUTICALS LTD
    Inventors: Olivier Bezencon, Christoph Boss, Daniel Bur, Austin Chih-Yu Chen, Olivier Corminboeuf, Daniel Dube, Walter Fischli, Corinna Grisostomi, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Michel Therien, Thomas Weller
  • Novel Thiophene Derivatives as Spingosine-1-Phosphate-1 Receptor Agonists
    Publication number: 20080194670
    Abstract: The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
    Type: Application
    Filed: March 20, 2006
    Publication date: August 14, 2008
    Applicant: ACTELION PHARMACEUTICALS LTD.
    Inventors: Martin Bolli, David Lehmann, Boris Mathys, Claus Mueller, Oliver Nayler, Jorg Velker, Thomas Weller
  • Hydrogenated Benzo (C) Thiophene Derivatives as Immunomodulators
    Publication number: 20080176926
    Abstract: The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
    Type: Application
    Filed: March 20, 2006
    Publication date: July 24, 2008
    Applicant: Actelion Pharmaceuticals Ltd.
    Inventors: Martin Bolli, David Lehmann, Boris Mathys, Claus Mueller, Oliver Nayler, Jorg Velker, Thomas Weller
  • Diazabicyclononene Derivatives and Use Thereof
    Publication number: 20080161313
    Abstract: The invention relates to a novel 3,9-diazabicycl?[3.3.1]nonene derivative of formula (I) and the enantiomers thereof and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing at least one compound of formula (I) or (I?) and especially their use as inhibitors of renin.(I).
    Type: Application
    Filed: January 26, 2006
    Publication date: July 3, 2008
    Applicant: ACTELION PHARMACEUTICALS LTD
    Inventors: Oliver Bezencon, Daniel Bur, Walter Fischli, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Thomas Weller
  • Microwireless integrated environmental sensor and transmitter system
    Patent number: 7386289
    Abstract: The invention is a microminiature wireless environmental sensor that has integrated both sensor and transmitter functions into one function. The basic operating principle for the device is that variable components of an RF circuit can be interfaced to the outside world environmental signals resulting in proportional changes in the transmission characteristics or transmission of data/bits from the RF transmitter circuit. This utilization of environmentally sensitive variable elements within a wireless transceiver circuit permits the fusion of both sensor and communications function into an integrated single function.
    Type: Grant
    Filed: February 3, 2005
    Date of Patent: June 10, 2008
    Assignee: University of South Florida
    Inventors: Thomas Weller, David Fries, Thomas Ketterl
  • Quinoline derivatives
    Patent number: 7375227
    Abstract: The invention relates to novel 1-pyridin-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: May 20, 2008
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Hamed Aissaoui, Christoph Binkert, Martine Clozel, Boris Mathys, Claus Mueller, Oliver Nayler, Michael Scherz, Jörg Velker, Thomas Weller
  • Novel Diazabicyclononene Derivative
    Publication number: 20080103152
    Abstract: The invention relates to a novel 3,9-diazabicyclo[3.3.1]nonene derivative and the enantiomers thereof and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing at least one compound of formula (I) or (I?) and especially their use as inhibitors of renin.
    Type: Application
    Filed: December 8, 2005
    Publication date: May 1, 2008
    Applicant: Actelion Pharmaceuticals Ltd
    Inventors: Olivier Bezencon, Daniel Bur, Walter Fisciili, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Hans-Peter Weber, Thomas Weller
  • Dual-polarized feed antenna apparatus and method of use
    Patent number: 7362273
    Abstract: An antenna apparatus and method for the interception of randomly polarized electromagnetic waves utilizing a dual polarized antenna which is excited through a cross-slot aperture using two well-isolated orthogonal feeds.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: April 22, 2008
    Assignee: University of South Florida
    Inventors: Mohammad Sarehraz, Kenneth A. Buckle, Elias Stefanakos, Thomas Weller, D. Yogi Goswami
  • Novel 4-Aminopiperidine Derivatives
    Publication number: 20080076762
    Abstract: Novel substituted 4-aminopiperidine derivatives of the formula I: wherein n, R1, Y, and are as defined in claim 1, and optically pure enantiomers, mixtures of enantiomers, racemates, diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates and meso-forms, as well as salts and solvent complexes of such compounds, and morphological forms, that exhibit useful parasite aspartic proteases inhibiting properties and can thus be used in the form of pharmaceutical compositions as antimalarial medicines.
    Type: Application
    Filed: November 21, 2005
    Publication date: March 27, 2008
    Applicant: ACTELION PHARMACEUTICALS LTD.
    Inventors: Christoph Boss, Daniel Bur, Olivier Corminboeuf, Corinna Grisostomi, Lars Prade, Thomas Weller
  • Novel Thiophene Derivatives
    Publication number: 20080064740
    Abstract: The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
    Type: Application
    Filed: July 20, 2005
    Publication date: March 13, 2008
    Applicant: ACTELION PHARMACEUTICALS, LTD.
    Inventors: Martin Bolli, Daniel Bur, Martine Clozel, Walter Fischli, David Lehmann, Boris Mathys, Claus Mueller, Oliver Nayler, Michael Scherz, Thomas Weller
  • 2,3-Oxidosqualene-lanosterol cyclase inhibitors
    Patent number: 7335687
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: February 26, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
  • Alkansulfonamides as endothelin antagonists
    Patent number: 7323465
    Abstract: The invention relates to novel alkansulfonamides of structure (I), wherein R1 is a lowel alzyl group and the other variables are as defined in the description, and their use as active ingredients in the preparation of pharmaceutical compositions.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: January 29, 2008
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Martin Bolli, Christoph Boss, Martine Clozel, Walter Fischli, Thomas Weller
  • Sulfamides as Endothelin Receptor Antagonists for the Treatment of Cardiovascular Diseases
    Publication number: 20080004298
    Abstract: The invention relates to novel sulfamic acid amides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.
    Type: Application
    Filed: November 11, 2005
    Publication date: January 3, 2008
    Applicant: ACTELION PHARMACEUTICALS LTD.
    Inventors: Martin Bolli, Christoph Boss, Martine Clozel, Walter Fischli, Thomas Weller
  • Sulfamides and their use as endothelin receptor antagonists
    Patent number: 7285549
    Abstract: The invention relates to novel sulfamides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: October 23, 2007
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Martin Bolli, Christoph Boss, Walter Fischli, Martine Clozel, Thomas Weller
  • SULFONYLAMINO-ACETIC ACID DERIVATIVES
    Publication number: 20070244156
    Abstract: The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
    Type: Application
    Filed: May 31, 2007
    Publication date: October 18, 2007
    Applicant: ACTELION PHARMACEUTICALS LTD.
    Inventors: Hamed Aissaoui, Martine Clozel, Walter Fischli, Ralf Koberstein, Thierry Sifferlen, Thomas Weller
  • System and Method for a Single Stage Tunable Ultra-Wideband Pulse Generator
    Publication number: 20070237208
    Abstract: The present invention provides a single-stage tunable Ultra-Wideband (UWB) pulse generator, by creating and differentiating a variable edge rate signal. Edge rate variability is introduced by first applying a step recovery diode (SRD) to compress the edges of the source and then applying a simple RC network to adjust the edge rate. Next, the resulting signal is differentiated using microstrip transmission lines. The tunable generator resulting from this approach demonstrates a Gaussian and monocycle pulses with good symmetry and low distortion over the tunable range.
    Type: Application
    Filed: December 19, 2006
    Publication date: October 11, 2007
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Erick Maxwell, Thomas Weller
  • Sulfonylamino-acetic acid derivatives
    Patent number: 7279578
    Abstract: The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: October 9, 2007
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Hamed Aissaoui, Martine Clozel, Walter Fischli, Ralf Koberstein, Thierry Sifferlen, Thomas Weller