Abstract: Provided herein are compositions and methods for activating pyruvate kinase (e.g., in a subject). In particular, provided herein are compositions and methods for treating a disease or condition (e.g., eye disease, blood disorders, or cancer) using pyruvate kinase activators.

Abstract: Provided herein are compositions and methods for treating eye disorders. In particular, provided herein are neuroprotective compositions and methods for treating vision loss and related disorders.

Abstract: An independent strut suspension utilizes upright twin spindles and a spindle cap linked to the spindles that translates vertically along the spindles as the suspension moves over uneven terrain. An upright strut shaft is mounted in a strut journal for axial and rotational movement with respect to the journal. A steering arm is connected for rotation about the strut shaft axis, and the strut shaft moves axially with respect to the steering arm as the frame moves over the uneven terrain. The upright spindles connect the steering arm and the upper mount, and a spring is supported between the upper end of the strut shaft and the upper mount and provides cushioning for the wheel support as the strut shaft moves axially in the journal.

Abstract: Foldable boom inner wings are attached to a boom center frame through a rocker attached to a breakaway hydraulic cylinder pressurized to full stroke and connected to an accumulator. When a wing impacts an object, the impact load is transmitted through the fold cylinder and rocker into the breakaway cylinder. As the breakaway cylinder retracts to allow the wing to pivot, pressure builds in the system in three stages. First pressure builds along an accumulator pressure curve until a relief valve in the hydraulic system actives to initiate the second stage wherein oil is dumped through the relief valve. Thereafter, pressure is again allowed to build along the same accumulator curve to absorb impact hydraulically before the cylinder reaches full stroke. The staged pressure buildup prevents boom momentum from gaining and loads from increasing above the strength of the overall structure.