Patents by Inventor Thomasz Szczepanski

Thomasz Szczepanski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETERMINING THE REPLICATIVE HISTORY OF LYMPHOCYTES
    Publication number: 20170298435
    Abstract: The invention relates to the field of immunology and immunodiagnostics. Provided is a method for determining the replicative history of a lymphocyte, preferably a B cell, the method comprising detecting a signal joint nucleotide sequence on an extrachromosomal circular excision product in the lymphocyte, wherein the excision product is deleted from a chromosome to give a chromosomal-coding joint nucleotide sequence, wherein the coding joint is retained in the chromosome, and detecting the coding joint nucleotide sequence in the lymphocyte. Also provided are primers, probes and a control cell for use in a method of the invention.
    Type: Application
    Filed: November 4, 2016
    Publication date: October 19, 2017
    Inventors: Jacobus J.M. van Dongen, Thomasz Szczepanski
  • Determining the replicative history of lymphocytes
    Patent number: 9487830
    Abstract: The invention relates to the field of immunology and immunodiagnostics. Provided is a method for determining the replicative history of a lymphocyte, preferably a B cell, the method comprising detecting a signal joint nucleotide sequence on an extrachromosomal circular excision product in the lymphocyte, wherein the excision product is deleted from a chromosome to give a chromosomal-coding joint nucleotide sequence, wherein the coding joint is retained in the chromosome, and detecting the coding joint nucleotide sequence in the lymphocyte. Also provided are primers, probes and a control cell for use in a method of the invention.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: November 8, 2016
    Assignee: Erasmus Universiteit Rotterdam
    Inventors: Jacobus J. M. van Dongen, Thomasz Szczepanski
  • Determining the replicative history of lymphocytes
    Publication number: 20070003951
    Abstract: The invention relates to the field of immunology and immunodiagnostics. Provided is a method for determining the replicative history of a lymphocyte, preferably a B cell, the method comprising detecting a signal joint nucleotide sequence on an extrachromosomal circular excision product in the lymphocyte, wherein the excision product is deleted from a chromosome to give a chromosomal-coding joint nucleotide sequence, wherein the coding joint is retained in the chromosome, and detecting the coding joint nucleotide sequence in the lymphocyte. Also provided are primers, probes and a control cell for use in a method of the invention.
    Type: Application
    Filed: April 24, 2006
    Publication date: January 4, 2007
    Applicant: Erasmus Universiteit Rotterdam
    Inventors: Jacobus van Dongen, Thomasz Szczepanski