Patents by Inventor Tianwei Ma

Tianwei Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GPR142 Agonist Compounds
    Publication number: 20170165234
    Abstract: The present invention provides compounds of the Formula (Ia) wherein R is selected from the group consisting of CH3, CH(CH3)2, CH2CN, CH2CHF2, CH2CF3, (A), (B), (C), (D), (E), (F), CH2CH2OCH3, and CH2C(O)OCH(CH3)2; R1 is selected from the group consisting of CF3, OCF3, and Cl; R2 is selected from the group consisting of H and F; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 22, 2015
    Publication date: June 15, 2017
    Inventors: Zhi Long Hu, Lian Zhu Liu, Tianwei Ma, Mi Emily Zeng, Jingye Zhou
  • Compounds and methods for modulating FXR
    Patent number: 8106077
    Abstract: Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: January 31, 2012
    Assignee: Eli Lilly and Company
    Inventors: Michael Gregory Bell, Robert Anthony Doti, Matthew Scott Dowling, Michael James Genin, Peter Ambrose Lander, Tianwei Ma, Nathan Bryan Mantlo, Jason Matthew Ochoada, Lindsay Scott Stelzer, Ryan Edward Stites, Alan M Warshawsky
  • Compounds and methods for modulating FX-receptors
    Patent number: 7863302
    Abstract: Compounds of formula and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: January 4, 2011
    Assignee: Eli Lilly and Company
    Inventors: Michael Gregory Bell, Michael James Genin, Peter Ambrose Lander, Lindsay Scott Stelzer, Robert Anthony Doti, Francisco Javier Agejas-Chicharro, Ana Belen Bueno Melendo, Peter Rudolph Manninen, Jason Matthew Ochoada, Quanrong Shen, Alan M. Warshawsky, Tianwei Ma, Ryan Edward Stites
  • FXR agonists
    Patent number: 7846960
    Abstract: Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: December 7, 2010
    Assignee: Eli Lilly and Company
    Inventors: Michael Gregory Bell, Robert Anthony Doti, Michael James Genin, Peter Ambrose Lander, Tianwei Ma, Peter Rudolph Manninen, Jason Matthew Ochoada, Fucheng Qu, Lindsay Scott Stelzer, Ryan Edward Stites, Alan M. Warshawsky
  • Vitamin D receptor modulators
    Patent number: 7772425
    Abstract: The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: August 10, 2010
    Assignee: Eli Lilly and Company
    Inventors: Emilio Enrique Bunel, Robert Peter Gajewski, Charles David Jones, Jianliang Lu, Tianwei Ma, Sunil Nagpal, Ying Kwong Yee
  • Vitamin D receptor modulators
    Patent number: 7750184
    Abstract: The present invention relates to novel, non-secosteroidal, sulfonate and sulfonamide functional diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: July 6, 2010
    Assignee: Eli Lilly and Company
    Inventors: Robert Peter Gajewski, Charles David Jones, Jared Harris Linebarger, Jianliang Lu, Tianwei Ma, Sunil Nagpal, Ying Kwong Yee
  • PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS
    Publication number: 20100099725
    Abstract: The present invention is directed to compounds of the structural Formula: wherein: R1 is H or —C1-C3 alkyl; R2 is selected from the group consisting of —H, —C1-C4 alkyl, —C1-C3 alkyl-CF3, phenyl, and pyridinyl; and R3 is selected from the group consisting of —H, —C1-C4 alkyl, —C1-C3 alkyl-O—CH3, —CH2-cyclopropyl, CH2—C?CH2, —CH2CH2-(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines; provided that when R1 and R2 are each H, then R3 is selected from the group consisting of —C1-C4 alkyl, —C1-C3 alkyl-O—CH3, —CH2-cyclopropyl, —CH2—C?CH2, —CH2CH2-(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines; or stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: February 12, 2008
    Publication date: April 22, 2010
    Inventors: Lance Allen Pfeifer, Tianwei Ma, Nathan Bryan Mantlo, Laura Frey Michael, Fese Mambo Mokube, Chahrzad Montrose-Rafizadeh
  • FXR AGONISTS
    Publication number: 20090270460
    Abstract: Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
    Type: Application
    Filed: May 22, 2007
    Publication date: October 29, 2009
    Inventors: Michael Gregory Bell, Robert Anthony Doti, Michael James Genin, Peter Ambrose Lander, Tianwei Ma, Peter Rudolph Manninen, Jason Matthew Ochoada, Fucheng Qu, Lindsay Scott Stelzer, Ryan Edward Stites, Alan M. Warshawsky
  • Phenyl-thiophene type vitamin D receptor modulators
    Patent number: 7601850
    Abstract: The present invention relates to novel, non-secosteroidal, phenyl-thiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
    Type: Grant
    Filed: May 22, 2003
    Date of Patent: October 13, 2009
    Assignee: Eli Lilly and Company
    Inventors: Karl Robert Dahnke, Robert Peter Gajewski, Charles David Jones, Jared Harris Linebarger, Jianliang Lu, Tianwei Ma, Sunil Nagpal, Todd Parker Simard, Ying Kwong Yee, Emilio Enrique Bunel, Ryan Edward Stites
  • Vitamin D receptor modulators
    Patent number: 7595345
    Abstract: The present invention relates to novel, non-secosteroidal, hydroxyl substituted, carbon-linked diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
    Type: Grant
    Filed: November 16, 2004
    Date of Patent: September 29, 2009
    Assignee: Eli Lilly and Company
    Inventors: Emilio Enrique Bunel, Robert Peter Gajewski, Charles David Jones, Jianliang Lu, Sunil Nagpal, Tianwei Ma, Ying Kwong Yee
  • VITAMIN D RECEPTOR MODULATORS
    Publication number: 20090227604
    Abstract: The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1a,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
    Type: Application
    Filed: May 22, 2009
    Publication date: September 10, 2009
    Inventors: Emilio Enrique Bunel, Robert Peter Gajewski, Charles David Jones, Jianliang Lu, Tianwei Ma, Sunil Nagpal, Ying Kwong Yee
  • Vitamin D receptor modulators
    Patent number: 7579488
    Abstract: The present invention relates to novel, non-secosteroidal, phenyl-benzofuran compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
    Type: Grant
    Filed: November 16, 2004
    Date of Patent: August 25, 2009
    Assignee: Eli Lilly and Company
    Inventors: Jianliang Lu, Tianwei Ma, Sunil Nagpal, Quanrong Shen, Alan M. Warshawsky, Jason Matthew Ochoada, Ying Kwong Yee
  • COMPOUNDS AND METHODS FOR MODULATING FXR
    Publication number: 20090093524
    Abstract: Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
    Type: Application
    Filed: May 22, 2007
    Publication date: April 9, 2009
    Inventors: Michael Gregory Bell, Robert Anthony Doti, Matthew Scott Dowling, Michael James Genin, Peter Ambrose Lander, Tianwei Ma, Nathan Bryan Mantlo, Jason Matthew Ochoada, Lindsay Scott Stelzer, Ryan Edward Stites, Alan M. Warshawsky
  • Triazole PPAR modulators
    Patent number: 7507832
    Abstract: The present invention is directed to compounds represented by the following structural formula, Formula (I): wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) W is N, O or S; (e) E is C(R3)(R4)A or A and wherein; (f) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsufonamide. The other substituents are defined in the claims; the compounds are modulators of peroxisome proleferator activated receptors (PPARs) and are useful for the treatment of diabetes and other metabolic disorders.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: March 24, 2009
    Assignee: Eli Lilly and Company
    Inventors: Nathan Bryan Mantlo, Antonio Navarro, Ashraf Saeed, Douglas Linn Gernert, Tianwei Ma, Lance Allen Pfeifer
  • Vitamin D Receptor Modulators
    Publication number: 20090018058
    Abstract: The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating and psoriasis.
    Type: Application
    Filed: November 20, 2003
    Publication date: January 15, 2009
    Applicant: ELI LILLY AND COMPANY
    Inventors: Emilio Enrique Bunel, Robert Peter Gajewski, Charles David Jones, Jianliang Lu, Tianwei Ma, Sunil Nagpal, Ying Kwong Yee
  • Phenyl-furan compounds as vitamin D receptor modulators
    Patent number: 7468449
    Abstract: The present invention relates to novel, non-secosteroidal, phenyl-furan compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
    Type: Grant
    Filed: November 16, 2004
    Date of Patent: December 23, 2008
    Assignee: Eli Lilly and Company
    Inventors: Robert Peter Gajewski, Charles David Jones, Jianliang Lu, Tianwei Ma, Sunil Nagpal, Ying Kwong Yee
  • Compounds and Methods for Modulating Fx-Receptors
    Publication number: 20080306125
    Abstract: Compounds of formula. wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
    Type: Application
    Filed: February 2, 2007
    Publication date: December 11, 2008
    Inventors: Michael Gregory Bell, Michael James Genin, Peter Ambrose Lander, Lindsay Scott Stelzer, Robert Anthony Doti, Francisco Javier Agejas-Chicharro, Ana Belen Bueno Melendo, Peter Rudolph Manninen, Jason Matthew Ochoada, Quanrong Shen, Alan M. Warshawsky, Tianwei Ma, Ryan Edward Stites
  • Vitamin D Receptor Modulators
    Publication number: 20080200552
    Abstract: The present invention relates to novel, non-secosteroidal, hydroxyl substituted, carbon-linked diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
    Type: Application
    Filed: November 16, 2004
    Publication date: August 21, 2008
    Applicant: ELI LILLY AND COMPANY
    Inventors: Emilio Enrique Bunel, Robert Peter Gajewski, Charles David Jones, Jianliang Lu, Sunil Nagpal, Tianwei Ma, Ying Kwong Yee
  • Triazole ppar modulators
    Publication number: 20070112045
    Abstract: The present invention is directed to compounds represented by the following structural formula, Formula (I): wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) W is N, O or S; (e) E is C(R3)(R4)A or A and wherein; (f) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsufonamide. The other substituents are defined in the claims; the compounds are modulators of peroxisome proleferator activated receptors (PPARs) and are useful for the treatment of diabetes and other metabolic disorders.
    Type: Application
    Filed: December 21, 2004
    Publication date: May 17, 2007
    Inventors: Nathan Mantlo, Antonio Navarro, Ashraf Saeed, Douglas Gernert, Tianwei Ma, Lance Pfeifer
  • Vitamin d receptor modulators
    Publication number: 20070106095
    Abstract: The present invention relates to novel, non-secosteroidal, phenyl-benzofuran compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
    Type: Application
    Filed: November 16, 2004
    Publication date: May 10, 2007
    Inventors: Jianliang Lu, Tianwei Ma, Sunil Nagpal, Quanrong Shen, Alan Warshawsky, Jason Ochoada, Ying Yee