Patents by Inventor Tianyi Krupka

Tianyi Krupka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilized nanobubbles for diagnostic and therapeutic applications
    Patent number: 10973935
    Abstract: A stabilized nanobubble can include a membrane that defines at least one internal void, which includes at least one gas. The membrane can include at least one lipid and at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: April 13, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Agata Exner, Tianyi Krupka, Luis Solorio
  • STABILIZED NANOBUBBLES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20200061220
    Abstract: A stabilized nanobubble can include a membrane that defines at least one internal void, which includes at least one gas. The membrane can include at least one lipid and at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble.
    Type: Application
    Filed: July 23, 2019
    Publication date: February 27, 2020
    Inventors: Agata Exner, Tianyi Krupka, Luis Solorio
  • Stabilized nanobubbles for diagnostic and therapeutic applications
    Patent number: 10357575
    Abstract: A stabilized nanobubble can include a membrane that defines at least one internal void, which includes at least one gas. The membrane can include at least one lipid and at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: July 23, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Agata Exner, Tianyi Krupka, Luis Solorio
  • Method for treating a neoplastic disorder
    Patent number: 9320757
    Abstract: A method for treating a neoplastic disorder in a subject includes administering to the neoplastic cells a neoplastic cell-sensitizing composition including a poly(ethylene oxide)-poly(propylene oxide) copolymer. The poly(ethylene oxide)-poly(propylene oxide) copolymer can sensitize the neoplastic cells to hyperthermia. Energy can be applied to the neoplastic cells to heat and ablate the cells.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: April 26, 2016
    Assignee: Case Western Reserve University
    Inventors: Agata Exner, Tianyi Krupka, Brent Weinberg, John Haaga
  • TOXICITY ENHANCING COMPOUNDS AND METHODS
    Publication number: 20160000824
    Abstract: A method of treating a tumor or cancer in a subject includes administering to cancer or tumor cells of the subject a radiation sensitizing amount of a poly(ethylene oxide)-poly(propylene oxide) copolymer and administering radiation therapy to the cancer or tumor cells sensitized by the poly(ethylene oxide)-poly(propylene oxide) copolymer.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 7, 2016
    Inventors: Agata Exner, Bryan J. Traughber, Tianyi Krupka, Reshani Perera, David Dremann
  • Toxicity enhancing compounds and methods
    Patent number: 9132149
    Abstract: A method of treating a tumor or cancer in a subject includes administering to cancer or tumor cells of the subject a radiation sensitizing amount of a poly(ethylene oxide)-poly(propylene oxide) copolymer and administering radiation therapy to the cancer or tumor cells sensitized by the poly(ethylene oxide)-poly(propylene oxide) copolymer.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: September 15, 2015
    Assignee: Case Western Reserve University
    Inventors: Agata Exner, Bryan J. Traughber, Tianyi Krupka, Reshani Perera, David Dremann
  • STABILIZED NANOBUBBLES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20140147390
    Abstract: A stabilized nanobubble can include a membrane that defines at least one internal void, which includes at least one gas. The membrane can include at least one lipid and at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble.
    Type: Application
    Filed: September 26, 2011
    Publication date: May 29, 2014
    Inventors: Agata Exner, Tianyi Krupka, Luis Solorio
  • TOXICITY ENHANCING COMPOUNDS AND METHODS
    Publication number: 20120225027
    Abstract: A method of treating a tumor or cancer in a subject includes administering to cancer or tumor cells of the subject a radiation sensitizing amount of a poly(ethylene oxide)-poly(propylene oxide) copolymer and administering radiation therapy to the cancer or tumor cells sensitized by the poly(ethylene oxide)-poly(propylene oxide) copolymer.
    Type: Application
    Filed: March 8, 2012
    Publication date: September 6, 2012
    Inventors: Agata Exner, Bryan J. Traughber, Tianyi Krupka, Reshani Perera, David Dremann
  • METHOD FOR TREATING A NEOPLASTIC DISORDER
    Publication number: 20080206187
    Abstract: A method for treating a neoplastic disorder in a subject includes administering to the neoplastic cells a neoplastic cell-sensitizing composition including a poly(ethylene oxide)-poly(propylene oxide) copolymer. The poly(ethylene oxide)-poly(propylene oxide) copolymer can sensitize the neoplastic cells to hyperthermia. Energy can be applied to the neoplastic cells to heat and ablate the cells.
    Type: Application
    Filed: November 29, 2007
    Publication date: August 28, 2008
    Inventors: Agata Exner, Tianyi Krupka, Brent Weinberg, John Haaga