Abstract: A method for preparing an aqueous solution of a defined pH comprising an acid, a base and optionally one or more additives is provided.

Abstract: A valve arrangement for use in a parking brake system of a commercial vehicle or trailer, includes a differential piston having a first section and a second section, wherein the second section has a smaller diameter compared to the first section, and wherein there is a fluidic connection between the first section and the second section. The arrangement includes a housing with a bore, in which the differential piston is adapted to move. The bore has at least two sections, wherein the first section corresponds to the diameter of the first section of the differential piston, and the second section corresponds to the diameter of the second section of the differential piston, and wherein a step is formed between the first section and second section of the bore. A first passage and a second passage are arranged and axially spaced in the bore, and a third passage is arranged in or next to the second section of the bore.

Abstract: A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.

Abstract: A rubber hose includes a distinctly colored inner wear indicator integrated into its liner, wherein a distance b of the inner wear indicator from the inner surface of the liner is less than 40% of the liner's thickness v, and height h of the wear indicator, measured perpendicularly to a longitudinal axis of the hose, falls between 1% to 90% of liner thickness v, or even from 10% to 40% of the liner thickness v. The inner wear indicator may have concentric sectional surface area of the inner wear indicator may even gradually decrease in the radial direction as a function of distance from the longitudinal axis. The rubber hose may be connected at one end to a plunger pump and connected at a second to a common manifold, in an oilfield pump system, or used in any hose application in an oilfield fluid pump system.

Abstract: A process for purifying a composition comprising water, a target substance, impurities and optionally cells, the process comprising the steps (A) and (B): (A) preparing a liquid feedstock by performing step (Ai) and/or (Aii) on the composition: (Ai) removing at least some of the cells from the composition; (Aii) concentrating the composition by removing water therefrom; and (B) passing the liquid feedstock through an apparatus comprising at least two processing units, each such unit producing a product stream containing purified target substance and optionally a waste stream comprising at least some of the impurities, wherein each unit comprises specified components (i) to (v). The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.

Abstract: Apparatus for purifying a liquid comprising a target substance comprising at least two units arranged in series such that the feed stream of the second and any subsequent units comprises the product stream from a downstream unit, wherein each unit comprises specified components (i) to (vi), including a a switchable bypass assembly. Also claimed are the units and a flowpath assembly. The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.

Abstract: Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means for mixing at least two liquids comprising a multiple inlet flow-controller, the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device configured in single-pass mode.

Abstract: A process for purifying a liquid feedstock comprising a monoclonal antibody and impurities, the process comprising passing the liquid feedstock through an apparatus comprising at least two processing units, each such unit producing a product stream containing purified monoclonal antibody and optionally a waste stream comprising at least some of the impurities, wherein each unit comprises specified components (i) to (v) which include a multiple inlet flow-controller comprising two or more variable flow inlet valves for in situ production of a bioprocessing liquid by combining at least two liquids in a desired ratio. One of the units performs chromatography and another performs viral inactivation. The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.

Abstract: A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.

Abstract: A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.

Abstract: Apparatus for processing a liquid comprising a target substance, preferably a biomolecule, is provided.

Abstract: Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means for mixing at least two liquids comprising a multiple inlet flow-controller, the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device configured in single-pass mode.

Abstract: A method for preparing an aqueous solution of a defined pH comprising an acid, a base and optionally one or more additives is provided.

Abstract: Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means (3) for mixing at least two liquids comprising a multiple inlet flow-controller (2), the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device (1) configured in single-pass mode.

Abstract: A high-pressure, large-bore bonded flexible rubber pipe resistant to aggressive chemicals and gases, particularly for conveying gas or oil, the flexible pipe having a liner made of poly(vinylidene-fluoride) homopolymer or copolymer wherein a hydrogenated nitrile rubber-based, peroxide-vulcanized rubber compound 2 is bonded to the poly(vinylidene-fluoride) liner, which has a Mooney 05, 150° C. scorch time of at least 10 minutes. Further, a method for manufacturing such hoses, the method including vulcanization performed at a temperature of at least 160° C.

Abstract: A high-pressure, large-bore bonded flexible rubber pipe resistant to aggressive chemicals and gases, particularly for conveying gas or oil, the flexible pipe having a liner made of poly(vinylidene-fluoride) homopolymer or copolymer wherein a hydrogenated nitrile rubber-based, peroxide-vulcanized rubber compound 2 is bonded to the poly(vinylidene-fluoride) liner, which has a Mooney 05, 150° C. scorch time of at least 10 minutes. Further, a method for manufacturing such hoses, the method including vulcanization performed at a temperature of at least 160° C.

Abstract: A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.

Abstract: Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means (3) for mixing at least two liquids comprising a multiple inlet flow-controller (2), the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device (1) configured in single-pass mode.

Abstract: A process for the production of a target recombinant polypeptide is provided. The process comprises expressing a vector comprising a promoter operatively linked to an expression cassette for the target recombinant polypeptide; and a perfect palindrome operator sequence in a culture medium, wherein the culture medium is substantially free from antibiotic.

Abstract: A high-pressure, large-bore bonded flexible rubber pipe resistant to aggressive chemicals and gases, particularly for conveying gas or oil, the flexible pipe having a liner made of poly(vinylidene-fluoride) homopolymer or copolymer wherein a hydrogenated nitrile rubber-based, peroxide-vulcanized rubber compound 2 is bonded to the poly(vinylidene-fluoride) liner, which has a Mooney 05, 150° C. scorch time of at least 10 minutes. Further, a method for manufacturing such hoses, the method including vulcanization performed at a temperature of at least 160° C.