Patents by Inventor Tiesheng Shi

Tiesheng Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical reagents for formation of disulfide bonds in peptides
    Publication number: 20040132965
    Abstract: This invention pertains to the discovery of a class of reagents that effectively form intramolecular disulfide bonds in peptides. Intermolecular disulfide linkage formation is low or essentially non-existent. In addition, preferred reagents of this invention are relatively mild and do not oxidize “vulnerable” residues in the subject peptide(s). In addition the reagents and reaction products are safe and essentially non-toxic. One particularly preferred reagent is [Pt(en)2Cl2]2+ where en is ethylenediamine.
    Type: Application
    Filed: October 6, 2003
    Publication date: July 8, 2004
    Applicant: The Regents of the University of California
    Inventors: Dallas A. Rabenstein, Tiesheng Shi
  • Chemical reagents for formation of disulfide bonds in peptides
    Patent number: 6686443
    Abstract: This invention pertains to the discovery of a class of reagents that effectively form intramolecular disulfide bonds in peptides. Intermolecular disulfide linkage formation is low or essentially non-existent. In addition, preferred reagents of this invention are relatively mild and do not oxidize “vulnerable” residues in the subject peptide(s). In addition the reagents and reaction products are safe and essentially non-toxic. One particularly preferred reagent is [Pt(en)2Cl2]2+ where en is ethylenediamine.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: February 3, 2004
    Assignee: The Regents of the University of California
    Inventors: Dallas L. Rabenstein, Tiesheng Shi