Patents by Inventor Tilman M. Hackeng

Tilman M. Hackeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Truncated cystine-knot proteins
    Patent number: 8772236
    Abstract: The invention relates to the fields of protein chemistry, biology and medicine. More specifically, it relates to the design and preparation of proteinmimics of members of the cystine-knot growth factor superfamily. Further, the invention relates to the use of these proteinmimics as a medicament or prophylactic agent. The invention provides proteinmimics of members of the cystine-knot growth factor superfamily, preferably for use in immunogenic and/or therapeutic compositions.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: July 8, 2014
    Assignees: Pepscan Systems B.V., Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Peter Timmerman, Wouter C. Puijk, Tilman M. Hackeng, Arjan W. Griffioen
  • TRUNCATED CYSTINE-KNOT PROTEINS
    Publication number: 20120231000
    Abstract: The invention relates to the fields of protein chemistry, biology and medicine. More specifically, it relates to the design and preparation of proteinmimics of members of the cystine-knot growth factor superfamily. Further, the invention relates to the use of these proteinmimics as a medicament or prophylactic agent. The invention provides proteinmimics of members of the cystine-knot growth factor superfamily, preferably for use in immunogenic and/or therapeutic compositions.
    Type: Application
    Filed: February 5, 2010
    Publication date: September 13, 2012
    Inventors: Peter Timmerman, Wouter C. Puijk, Tilman M. Hackeng, Arjan W. Griffioen
  • Regulation of Tissue Factor Activity by Protein S and Tissue Factor Pathway Inhibitor
    Publication number: 20080161425
    Abstract: The present invention relates to methods for the identification of compounds that increase or decrease the inhibitory effect of TFPI on tissue factor activity and/or Factor Xa activity and/or thrombin formation. The invention also relates to methods for the identification of compounds that increase or decrease the co-factor activity of Protein S in TFPI-mediated inhibition of tissue factor and/or Factor Xa activity. This invention also relates to a pharmaceutical composition comprising the compounds identifiable by such methods. The invention also relates to methods for the regulation of tissue factor activity by influencing the interaction between Protein S and Tissue Factor Pathway Inhibitor.
    Type: Application
    Filed: July 28, 2006
    Publication date: July 3, 2008
    Applicant: Universiteit Van Maastricht
    Inventors: Tilman M. Hackeng, Kristin M. Sere, Guido Tans, Jan Rosing