Patents by Inventor Tim Matthias Strom
Tim Matthias Strom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170240867Abstract: The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.Type: ApplicationFiled: June 22, 2015Publication date: August 24, 2017Applicants: Baxalta GmbH, Baxalta IncorporatedInventors: Johannes OLDENBURG, Clemens R. MUELLER-REIBLE, Andreas FREGIN, Simone ROST, Tim-Matthias STROM
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Patent number: 8586317Abstract: The present invention relates to methods of diagnosing hypophosphatemic disorders.Type: GrantFiled: April 11, 2011Date of Patent: November 19, 2013Assignees: Advanced Research & Technology Institute, Ludwig-Maximilians-Universitat Munchen Abeteilung Mediziniche GenetikInventors: Michael Econs, Kenneth E. White, Tim Matthias Strom, Thomas Meitinger
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Patent number: 8409809Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: GrantFiled: August 26, 2011Date of Patent: April 2, 2013Assignees: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Eberhard-Karls-Universitaet Tuebingen, Mayo Foundation For Medical Education and ResearchInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
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Publication number: 20120064544Abstract: The present invention relates to methods of diagnosing hypophosphatemic disorders.Type: ApplicationFiled: April 11, 2011Publication date: March 15, 2012Inventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20120035072Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: ApplicationFiled: August 26, 2011Publication date: February 9, 2012Applicants: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH, Mayo Foundation for Medical Education and Research, Eberhard Karls Universitaet TuebingenInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra (Leitner) Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
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Patent number: 8029986Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: GrantFiled: September 27, 2005Date of Patent: October 4, 2011Assignees: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt(GmbH), Eberhard Karls Universitaet Tuebingen, Mayo Foundation for Medical Education and ResearchInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
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Publication number: 20110154520Abstract: The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.Type: ApplicationFiled: November 10, 2010Publication date: June 23, 2011Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: Johannes Oldenburg, Clemens R. Mueller-Reible, Andreas Fregin, Simone Rost, Tim-Matthias Strom
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Patent number: 7947810Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.Type: GrantFiled: November 7, 2007Date of Patent: May 24, 2011Assignees: Advanced Research & Technology Institute, Ludwig-Maximilians-Universitat Munchen Abeteilung Mediziniche GenetikInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Patent number: 7939250Abstract: The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.Type: GrantFiled: October 14, 2004Date of Patent: May 10, 2011Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Johannes Oldenburg, Clemens R. Müller-Reible, Andreas Fregin, Simone Rost, Tim-Matthias Strom
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Publication number: 20100235933Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: ApplicationFiled: September 27, 2005Publication date: September 16, 2010Applicants: Mayo Clinic, GSF Forschungszentrum fuer umwelt und Gesundheit GmbH, Eberhard Karls Universitaet TuebingenInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Gloeckner, Thomas Gasser, Petra Leitner, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
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Patent number: 7745406Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.Type: GrantFiled: November 7, 2007Date of Patent: June 29, 2010Assignees: Advanced Research & Technology Institute, Ludwig-Maximilians-Universitat Munchen Abteilung Medizinische GenetikInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20090311792Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.Type: ApplicationFiled: November 7, 2007Publication date: December 17, 2009Inventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20090094708Abstract: The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.Type: ApplicationFiled: September 5, 2008Publication date: April 9, 2009Applicants: Baxter International Inc., Baxter Heathcare CorporationInventors: Johannes Oldenburg, Clemens R. Muller-Reible, Andreas Fregin, Simone Rost, Tim-Matthias Strom
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Publication number: 20080241946Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.Type: ApplicationFiled: November 7, 2007Publication date: October 2, 2008Inventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Patent number: 7314618Abstract: The present invention relates to antibodies that bind to FGF23 polypeptides and to FGF23 mutant polypeptides.Type: GrantFiled: March 4, 2003Date of Patent: January 1, 2008Assignees: Advanced Research and Technology Institute, Ludwig-Maximilians-Universtat MunchenInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Patent number: 7223563Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.Type: GrantFiled: July 10, 2001Date of Patent: May 29, 2007Assignees: Advanced Research and Technology Institute, Ludwig-Maximilians-Universitat MuchenInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20050271644Abstract: The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.Type: ApplicationFiled: October 14, 2004Publication date: December 8, 2005Inventors: Johannes Oldenburg, Clemens Muller-Reible, Andreas Fregin, Simone Rost, Tim-Matthias Strom
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Publication number: 20030181379Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.Type: ApplicationFiled: March 4, 2003Publication date: September 25, 2003Applicant: Advanced Research & Technology Institute and Ludwig-Maximilians-Universitat MunchenInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20020156001Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.Type: ApplicationFiled: July 10, 2001Publication date: October 24, 2002Applicant: Advanced Research & Technology Institute and Ludwig-Maximilians-Universitat MunchenInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger