Abstract: Disclosed herein are methods of identifying a cell type by its genomic methylation pattern from a biological sample of a human subject. In some cases, the method can comprise identifying sperm and/or prostate cells. Also described herein are methods of identifying cell types for forensic analysis and for the treatment of a disease. The methods disclosed herein may comprise determining the DNA methylation pattern of DNA extracted from a semen sample. Also disclosed herein are methods of treating a disease or condition of a subject.

Abstract: Coupling components which prevent relative rotation between tubular members when break away torque forces are applied to the tubular members. In one embodiment, the invention is a locking ring for preventing relative axial rotation between two generally tubular members. The ring is shaped to receive a sealing gasket and has two side faces wherein each side face is shaped to frictionally engage one of the tubular members to thereby prevent relative axial rotation between the tubular members. The invention is also directed to a coupling including a locking ring. The tubular members are generally coaxially arranged such that the sealing faces face each other. The coupling comprises a sealing gasket captured between the sealing beads for sealing the coupling, wherein the frictional surfaces engage the sealing gasket to prevent relative rotation between the tubular members.

Abstract: Coupling components which prevent relative rotation between tubular members when break away torque forces are applied to the tubular members. In one embodiment, the invention is a locking ring for preventing relative axial rotation between two generally tubular members. The ring is shaped to receive a sealing gasket and has two side faces wherein each side face is shaped to frictionally engage one of the tubular members to thereby prevent relative axial rotation between the tubular members. The invention is also directed to a coupling including a locking ring. The tubular members are generally coaxially arranged such that the sealing faces face each other. The coupling comprises a sealing gasket captured between the sealing beads for sealing the coupling, wherein the frictional surfaces engage the sealing gasket to prevent relative rotation between the tubular members.

Abstract: Couplings and coupling components which prevent relative rotation between tubular members when break away torque forces are applied to the tubular members. In one embodiment, the invention is a locking ring for preventing relative axial rotation between two generally tubular members. The ring is shaped to receive a sealing gasket and has two side faces wherein each side face is shaped to frictionally engage one of the tubular members to thereby prevent relative axial rotation between the tubular members. The invention is also directed to a coupling including a locking ring and a method of making a coupling having a locking ring to prevent relative rotation between the tubular members. In another preferred embodiment, the invention is a coupling comprising two generally tubular members each having a sealing end face, a raised, annular sealing bead, an inner bore, and a frictional surface located radially outward of the sealing bead.

Abstract: A coupling assembly includes first and second coupling members or glands having end faces that sealingly engage opposite faces of an annular gasket. An end face of the coupling member includes a circumferentially continuous seal bead disposed adjacent the bore of the coupling member. A bead thus contacts the gasket along a radially inner region thereof. Disposed over a major portion of the radial face is a substantially planar region. The planar region is adapted to engage the gasket during make-up so that the user encounters an increase or positive feedback of increased torque once the coupling assembly is properly made-up. The end face also includes a raised ring disposed along the radial perimeter. The ring extends outwardly from the end face a dimension slightly greater than that of the bead so that it provides initial engagement with the gasket. This locks the coupling member and gasket against relative rotation during make-up.

Abstract: A coupling assembly includes first and second coupling members or glands having end faces that sealingly engage opposite faces of an annular gasket. An end face of the coupling member includes a circumferentially continuous seal bead disposed adjacent the bore of the coupling member. A bead thus contacts the gasket along a radially inner region thereof. Disposed over a major portion of the radial face is a substantially planar region. The planar region is adapted to engage the gasket during make-up so that the user encounters an increase or positive feedback of increased torque once the coupling assembly is properly made-up. The end face also includes a raised ring disposed along the radial perimeter. The ring extends outwardly from the end face a dimension slightly greater than that of the bead so that it provides initial engagement with the gasket. This locks the coupling member and gasket against relative rotation during make-up.

Abstract: Couplings and coupling components which prevent relative rotation between tubular members when break away torque forces are applied to the tubular members. In one embodiment, the invention is a locking ring for preventing relative axial rotation between two generally tubular members. The ring is shaped to receive a sealing gasket and has two side faces wherein each side face is shaped to frictionally engage one of the tubular members to thereby prevent relative axial rotation between the tubular members. The invention is also directed to a coupling including a locking ring and a method of making a coupling having a locking ring to prevent relative rotation between the tubular members. In another preferred embodiment, the invention is a coupling comprising two generally tubular members each having a sealing end face, a raised, annular sealing bead, an inner bore, and a frictional surface located radially outward of the sealing bead.