Patents by Inventor Timothy A. Smith
Timothy A. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11994528Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.Type: GrantFiled: December 15, 2020Date of Patent: May 28, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Alexandre Vlassov, Timothy Barta, Justin Inslee, Ethan Gentert, Robert Smith, Sara Thiele, Carolyn Adams, Kraig Kruger, Robert Schneider, Wade Lukianow, Jay Greco, Jason Jones, David Cerrone, Sumonto Ghosh, Brian Vajda, Andrew Basta, Allan Evans, Christopher Crowley, Robert Setterquist, Anne Cox, Mark Mayernick
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Patent number: 11982601Abstract: The present disclosure provides a method of cell sedimentation and retention of target cells, for example circulating tumour cells, CTC, from a fluid sample onto a solid support. The method comprises placing a fluid medium comprising the target cells in a fluid chamber, the fluid chamber having an open end sealed against a surface of the solid support. The method further comprises subjecting the fluid medium to centrifugation within the fluid chamber to induce sedimentation of the target cells and promote cell adhesion to the surface of the solid support. The method further comprises, post-centrifugation, positioning a fluid absorbing element in the fluid chamber to remove fluid from the fluid chamber. The method further comprises controlling a flow rate of the fluid being absorbed by the fluid absorbing element such that the sedimented cells are not detached from the surface of the solid support.Type: GrantFiled: February 27, 2023Date of Patent: May 14, 2024Assignee: ANGLE EUROPE LIMITEDInventors: Alexandre Izmailov, Brian Pak, Tomoyuki Sen, Paul Timothy Smith
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Patent number: 11970287Abstract: An introduced autonomous aerial vehicle can include multiple cameras for capturing images of a surrounding physical environment that are utilized for motion planning by an autonomous navigation system. In some embodiments, the cameras can be integrated into one or more rotor assemblies that house powered rotors to free up space within the body of the aerial vehicle. In an example embodiment, an aerial vehicle includes multiple upward-facing cameras and multiple downward-facing cameras with overlapping fields of view to enable stereoscopic computer vision in a plurality of directions around the aerial vehicle. Similar camera arrangements can also be implemented in fixed-wing aerial vehicles.Type: GrantFiled: July 26, 2022Date of Patent: April 30, 2024Assignee: Skydio, Inc.Inventors: Benjamin Scott Thompson, Adam Parker Bry, Asher Mendel Robbins-Rothman, Abraham Galton Bachrach, Yevgeniy Kozlenko, Kevin Patrick Smith O'Leary, Patrick Allen Lowe, Daniel Thomas Adams, Justin Michael Sadowski, Zachary Albert West, Josiah Timothy VanderMey
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Publication number: 20240132720Abstract: A footwear article comprises: an outsole comprising: an outsole body comprising a first polyurethane polymeric material attached to one or more tread cleats comprising a nitrile butadiene rubber polymeric material; and a footwear upper affixed to the outsole, the footwear upper comprising a second polyurethane polymeric material. Footwear articles, including boots, overshoes, and/or work shoes, are effective to meet or exceed slip resistance in accordance with ASTM F3445-21. Methods of making the footwear articles are also described.Type: ApplicationFiled: October 15, 2023Publication date: April 25, 2024Applicant: Tingley Rubber CorporationInventors: James P. Towey, Robert N. Petersen, Steven A. Smith, Timothy L. Cullen
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Publication number: 20240135139Abstract: Methods and systems for implementing a traditional computer vision algorithm as a neural network. The method includes: receiving a definition of the traditional computer vision algorithm that identifies a sequence of one or more traditional computer vision algorithm operations; mapping each of the one or more traditional computer vision algorithm operations to a set of one or more neural network primitives that is mathematically equivalent to that traditional computer vision algorithm operation; linking the one or more network primitives mapped to each traditional computer vision algorithm operation according to the sequence to form a neural network representing the traditional computer vision algorithm; and configuring hardware logic capable of implementing a neural network to implement the neural network that represents the traditional computer vision algorithm.Type: ApplicationFiled: April 19, 2023Publication date: April 25, 2024Inventors: Paul Brasnett, Daniel Valdez Balderas, Cagatay Dikici, Szabolcs Csefalvay, David Hough, Timothy Smith, James Imber
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Publication number: 20240102605Abstract: A multi-legged equipment support, components thereof, and associated methods. The equipment support comprises a stand and an equipment holder. The stand includes a hub and multiple legs pivotable with respect to the hub. The legs are pivotable outward from stowed positions to preset operational pivoted positions. The user can select a preset operational pivoted position in which outward pivoting of a leg will stop based on moving an actuator between preset locations.Type: ApplicationFiled: December 11, 2023Publication date: March 28, 2024Applicant: AOB Products CompanyInventors: Brian Steere, Michael Cottrell, Timothy S. Kinney, James Tayon, Jason Nickerson, Justin Burke, Anthony Vesich, Dennis W. Cauley, JR., Mark Dalton, Kyle Smith
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Patent number: 11940855Abstract: Three components are used to adjust the CPU peak power based on the USB TYPE-C device states. These components include operating system (OS) Peak Power Manager, USB TYPE-C Connector Manager, and USB TYPE-C Protocol Device Driver. The USB TYPE-C Connector Manager sends a synchronous request to the OS Peak Power Manager when a USB TYPE-C power sink device is attached or detached, and the USB TYPE-C Protocol Device Driver sends a synchronous request to the Peak Power Manager when the power sink transitions device state. The Peak Power Manager takes power budget from the CPU when the USB TYPE-C connector is attached to a power sink and is active (e.g., high power device state), and gives back the power budget to the CPU for performance when the USB TYPE-C connector is either detached or the attached and power sink device is idle (lowest device state).Type: GrantFiled: October 12, 2020Date of Patent: March 26, 2024Assignee: Intel CorporationInventors: Ashwin Umapathy, Chee Lim Nge, Timothy Smith, Dmitriy Berchanskiy, Vinay Raghav
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Patent number: 11942404Abstract: Apparatuses, such as semiconductor device packages, may include, for example, a device substrate including a semiconductor material and bond pads coupled with an active surface of the device substrate. A package substrate may be secured to the device substrate, the package substrate configured to route signals to and from the bond pads. A ball grid array may be supported on, and electrically connected to, the package substrate. Each ball of the ball grid array positioned and configured to carry a clock signal or a strobe signal may be located in a central column of the ball grid array.Type: GrantFiled: August 25, 2021Date of Patent: March 26, 2024Assignee: Micron Technology, Inc.Inventors: Matthew B. Leslie, Timothy M. Hollis, Scott R. Cyr, Stephen F. Moxham, Matthew A. Prather, Scott Smith
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Publication number: 20240082417Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.Type: ApplicationFiled: July 14, 2022Publication date: March 14, 2024Inventors: Roger A. Smith, Nitin K. Damle, Aleksandr V. Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Joshua D. Thomas, Cheri A. Stevenson, Venu R. Gurijala
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Publication number: 20240090086Abstract: The present disclosure relates to a cartridge for an aerosol delivery device such as a smoking article. The cartridge may include a base, a reservoir substrate, and an atomizer. The reservoir substrate may define a cavity therethrough. The atomizer may comprise a liquid transport element and a heating element extending at least partially about the liquid transport element. The atomizer may extend through the cavity through the reservoir substrate such that the heating element is positioned proximate an end of the reservoir substrate. Ends of the liquid transport element may extend to an opposing end of the reservoir substrate. A related method for assembling a cartridge for a smoking article is also provided.Type: ApplicationFiled: November 17, 2023Publication date: March 14, 2024Inventors: John DePiano, David Smith, Charles Jacob Novak, III, Frank S. Silveira, Steven Lee Alderman, Grady Lance Dooly, Frederic Philippe Ampolini, Timothy Brian Nestor, Quentin Paul Guenther, JR., Stephen Benson Sears, John William Wolber, Michael Laine
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Publication number: 20240077282Abstract: An anti-cant indicator assembly, components thereof, and associated methods. The anti-cant indicator assembly indicates the orientation of a weapon with respect to vertical. The anti-cant indicator assembly includes a mount configured to mount to the weapon, a level including a vial containing a bubble and a pivot connection connecting the level to the mount. The pivot connection is configured to permit movement of the level with respect to the mount about the pivot connection between an operational position in which the bubble can be referenced by the user for indicating orientation of the weapon with respect to vertical, and a stowed position different from the operational position. The pivot connection can include a retainer configured to releasably retain the level in at least one of the operational position or the stowed position. The level can be selectively movable with respect to the mount to calibrate the anti-cant indicator.Type: ApplicationFiled: November 10, 2023Publication date: March 7, 2024Applicant: AOB Products CompanyInventors: Mike Lindsay, Michael Cottrell, James Tayon, Timothy S. Kinney, Mark Dalton, Brian Steere, Justin Burke, Kyle Martin, Dennis W. Cauley, JR., Anthony Vesich, Ryan Varnum, Seth Wheeler, Brett Eckelkamp, Matthew Kinamore, Curtis Smith
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Patent number: 11919179Abstract: An out-the-front knife, components thereof, and associated methods. The out-the front knife can be a double-action spring-assisted knife. The knife includes a handle and a blade. The handle includes a rear end and a front opening opposite the rear end. The blade is movable with respect to the handle between stowed and deployed positions. In the stowed position, the blade is biased rearward. The knife includes an actuator movable in a deploying direction to spring the blade forward away from the stowed position toward the deployed position.Type: GrantFiled: March 31, 2021Date of Patent: March 5, 2024Assignee: AOB Products CompanyInventors: Brett Eckelkamp, Michael Cottrell, Shane Ball, William Garland, Brian Steere, Timothy S. Kinney, Seth Wheeler, Justin Burke, James Tayon, Curtis Smith
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Publication number: 20240065716Abstract: A surgical device includes a pair of jaws for manipulating tissue disposed therebetween; a housing and a hemostat style gripping mechanism; an elongated shaft positioned between the housing and the pair of jaws and defining a longitudinal axis; and a pull tube at least partially disposed within the elongated shaft. The hemostat style gripping mechanism comprises a linkage system configured to move the jaws between an open position and an approximated position, the linkage system comprises a first shank having distal end rotatably coupled to the housing at a first fixed pivot point and a proximal end coupled to a first finger grip, a second shank having a distal end rotatably coupled to the housing at a second fixed pivot point and a proximal end coupled to a second finger grip, and a slider link operatively coupled to the first shank and the second shank.Type: ApplicationFiled: October 26, 2023Publication date: February 29, 2024Applicant: BOLDER SURGICAL, LLCInventors: Nathan Steketee, Timothy Crowley, Christopher Deborski, Russell Hempstead, Ryan Smith, John Twomey
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Patent number: 11912545Abstract: A wireless hoist system including a first hoist device having a first motor and a first wireless transceiver and a second hoist device having a second motor and a second wireless transceiver. The wireless hoist system includes a controller in wireless communication with the first wireless transceiver and the second wireless. The controller is configured to receive a user input and determine a first operation parameter and a second operation parameter based on the user input. The controller is also configured to provide, wirelessly, a first control signal indicative of the first operation parameter to the first hoist device and provide, wirelessly, a second control signal indicative of the second operation parameter to the second hoist device. The first hoist device operates based on the first control signal and the second hoist device operates based on the second control signal.Type: GrantFiled: June 26, 2020Date of Patent: February 27, 2024Assignee: Milwaukee Electric Tool CorporationInventors: Matthew Post, Gareth Mueckl, Matthew N. Thurin, Joshua D. Widder, Timothy J. Bartlett, Patrick D. Gallagher, Jarrod P. Kotes, Karly M. Schober, Kenneth W. Wolf, Terry L. Timmons, Mallory L. Marksteiner, Jonathan L. Lambert, Ryan A. Spiering, Jeremy R. Ebner, Benjamin A. Smith, James Wekwert, Brandon L. Yahr, Troy C. Thorson, Connor P. Sprague, John E. Koller, Evan M. Glanzer, John S. Scott, William F. Chapman, III, Timothy R. Obermann
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Publication number: 20240052311Abstract: The present disclosure provides an automated method of producing genetically modified immune cells, including chimeric antigen receptor T (CAR T) cells, utilizing a fully-enclosed cell engineering system.Type: ApplicationFiled: October 27, 2023Publication date: February 15, 2024Inventors: Yaling SHI, Erika MCAFEE, Samatha BANDAPALLE, Ann SIEHOFF, Timo GLEISSNER, Joseph O'CONNOR, Eytan ABRAHAM, Kelly PURPURA, Nuala TRAINOR, Timothy SMITH
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Publication number: 20240029287Abstract: A method of feature matching in images captured from camera viewpoints uses the epipolar geometry of the viewpoints to define a geometrically-constrained region in a second image corresponding to a first feature in a first image; comparing the local descriptor of the first feature with local descriptors of features in the second image to determine respective measures of similarity; identifying, from the features located in the geometrically-constrained region, (i) a geometric best match and (ii) a geometric next-best match to the first feature; identifying a global best match to the first feature; performing a first comparison of the measures of similarity for the geometric best match and the global best match; performing a second comparison of the measures of similarity for the geometric best match and the geometric next-best match; and, if thresholds are met, selecting the geometric best match feature in the second image.Type: ApplicationFiled: September 11, 2023Publication date: January 25, 2024Inventors: Ruan Lakemond, Timothy Smith
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Publication number: 20240018473Abstract: The present disclosure provides an automated method of producing genetically modified immune cells, including chimeric antigen receptor T (CAR T) cells, utilizing a fully-enclosed cell engineering system.Type: ApplicationFiled: September 22, 2023Publication date: January 18, 2024Inventors: Yaling SHI, Erika MCAFEE, Samatha BANDAPALLE, Ann SIEHOFF, Timo GLEISSNER, Joseph O'CONNOR, Eytan ABRAHAM, Kelly PURPURA, Nuala TRAINOR, Timothy SMITH
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Patent number: 11851982Abstract: A well tool can include a body and at least one barrier element. The barrier element can include a pyrolytically degradable material that is positionable to block a flow of fluid across the body within a wellbore and to degrade by pyrolysis over time within the wellbore.Type: GrantFiled: April 12, 2021Date of Patent: December 26, 2023Assignee: Halliburton Energy Services, Inc.Inventors: Michael Linley Fripp, Charles Timothy Smith, Chad William Glaesman
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Publication number: 20230400392Abstract: The present disclosure provides a method of cell sedimentation and retention of target cells, for example circulating tumour cells, CTC, from a fluid sample onto a solid support. The method comprises placing a fluid medium comprising the target cells in a fluid chamber, the fluid chamber having an open end sealed against a surface of the solid support. The method further comprises subjecting the fluid medium to centrifugation within the fluid chamber to induce sedimentation of the target cells and promote cell adhesion to the surface of the solid support. The method further comprises, post-centrifugation, positioning a fluid absorbing element in the fluid chamber to remove fluid from the fluid chamber. The method further comprises controlling a flow rate of the fluid being absorbed by the fluid absorbing element such that the sedimented cells are not detached from the surface of the solid support.Type: ApplicationFiled: February 27, 2023Publication date: December 14, 2023Inventors: Alexandre Izmailov, Brian Pak, Tomoyuki Sen, Paul Timothy Smith
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Patent number: D1024323Type: GrantFiled: September 11, 2020Date of Patent: April 23, 2024Assignee: Bolder Surgical, LLCInventors: Patricia Jurek, Clayton Cole, Christopher Deborski, Serge Dubeau, Keir Hart, Russ Hempstead, Ryan Smith, Jorge Trevino Blanco, Timothy Crowley