Abstract: The invention provides arylthioether acetamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as bacterial infections, and in inhibiting LpxA activity.

Abstract: Devices for affixing sutures, grafts and tissues to bone, and soft tissue such as periosteum. In a first embodiment, the invention comprises a piton member implantable within bone having a post or eyelet formed thereon to which the suture or tissue may be attached. The piton member is designed to become more firmly secured within the bone when pressure is applied to a first axis pushing the piton member into the bone, but may be easily removed when such force is applied in a generally opposed direction. In a second embodiment, the invention comprises affixation devices that are designed to detachably ensnare with periosteum. Such devices are provided with attachment structures, such as one post, eyelet or other means for securing sutures, grafts, synthetic materials or tissues.