Abstract: This disclosure describes methods for organoid generation including, for example, for generation of a multi-tissue organoid. The multi-tissue organoid may include cartilage, bone, epithelium, and/or fibrous connective tissue. This disclosure further describes methods for isolating cells from the organoids and methods of using the organoids and cells of the organoids.

Abstract: Fully dissolved, aqueous solutions of polycationic macromolecules and polyanionic macromolecules with a cell suspension are mixed to form a three dimensional hydrogel, useful for clinical, diagnostic, and therapeutic applications.

Abstract: This disclosure describes methods for organoid generation including, for example, for generation of a mid-brain organoid including an A9 neuron. Specifically, the methods comprising: introducing an input cell into a cell culture medium comprising hyaluronic acid, wherein the input cell comprises an embryonic stem cell, an induced pluripotent stem cell, or a neural progenitor cell; transferring the input cell to a cell culture device; and culturing the cell in the cell culture device for at least 7 days. This disclosure further describes methods for using the organoids.

Abstract: Papermaker's forming fabrics including extruded thermoplastic monofilaments formed from a polymer blend consisting of from about 51%-90% pbw (parts by weight) of a poly(ethylene naphthalate) (PEN) polymer having a melt point of from 249° C. to about 278° C., most preferably between about 262° C. and 273° C., and an intrinsic viscosity of from 0.45 to about 0.95, preferably from about 0.65 to about 0.85, along with from about 49%-10% pbw of a poly(ethylene terephthalate) (PET) polymer having an intrinsic viscosity of between about 0.55 to about 1.05, preferably from about 0.85 to 1.0. Monofilaments formed from the novel polymer blend exhibit physical properties differing from those obtained from monofilaments formed of 100% PEN polymer, making them particularly suitable for use in weaving and processing the forming fabrics of the present invention.

Abstract: Papermaker's forming fabrics including extruded thermoplastic monofilaments formed from a polymer blend consisting of from about 51%-90% pbw (parts by weight) of a poly(ethylene naphthalate) (PEN) polymer having a melt point of from 249° C. to about 278° C., most preferably between about 262° C. and 273° C., and an intrinsic viscosity of from 0.45 to about 0.95, preferably from about 0.65 to about 0.85, along with from about 49%-10% pbw of a poly(ethylene terephthalate) (PET) polymer having an intrinsic viscosity of between about 0.55 to about 1.05, preferably from about 0.85 to 1.0. Monofilaments formed from the novel polymer blend exhibit physical properties differing from those obtained from monofilaments formed of 100% PEN polymer, making them particularly suitable for use in weaving and processing the forming fabrics of the present invention.

Abstract: Methods and apparatus for plasma modifying a substrate are disclosed along with associated techniques for applying coatings to the substrate. Particular utility has been found using a hollow cathode to generate the plasma along with magnetic focusing means to focus the plasma at the surface of a substrate.

Abstract: Methods and apparatus for plasma modifying a substrate are disclosed along with associated techniques for applying coatings to the substrate. Particular utility has been found using a hollow cathode to generate the plasma along with magnetic focusing means to focus the plasma at the surface of a substrate.

Abstract: Level (i.e., uniform diameter along the length thereof) and tapered (varying diameter along the length thereof) brush bristles include a central core having an outer wall and a pair of internal, semi-cylindrical passages separated by a central dividing wall. A plurality of spokes, or ribs, extend radially outwardly from the outer wall of the central core in planes other than the plane of the central dividing wall and also are spaced equidistant from each other about the circumference of the outer wall. Applicator brushes employing the aforementioned bristles also form a part of this invention.

Abstract: A polymer bristle (100) for a liquid-applying brush such as a paint brush includes in cross section a central bore (95), an annulus (96) and preferably three radiating spokes (97) with parallel sides and rounded tips. The bristle is tapered from a thick end (101) that is bundled into the ferrule of a brush toward a thin end (103). The bristle may be flagged by slits (130).

Abstract: Microcellular carbon filaments having a specific gravity about 20-30% less than conventional carbon fibers made of the same precursor resin are formed by foaming the precursor resin during spinning. These low density microcellular carbon filaments, which may also be hollow, have improved insulation properties compared with conventional carbon fibers, they have a higher than expected strength to weight ratio and adhere in a superior fashion to a variety of matrix materials.

Abstract: Hollow carbon and graphite filaments having a specific gravity of about 20-50% less than conventional solid carbon fibers made of the same precursor resin are formed by spinning hollow precursor resin filaments. These low density hollow carbon filaments have improved insulating properties compared with conventional solid carbon fibers and have an excellent bending strength to weight ratio.

Abstract: Synthetic microcellular paintbrush bristles are produced having a generally consistent cross-sectional shape along their length and a rough and irregular surface. The bristles comprise 15 to 40% cells on a volume basis, the cells being predominantly closed in the interior of the bristle and being open along the wall to provide the rough and irregular surface.