Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, CY, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: A power generation system with a predetermined rating limit includes one or more wind turbine generators and a vanadium redox battery. The vanadium redox battery absorbs excess energy to ensure that the rating limit is not exceeded, provide system stability, and improve power generation availability. The power generation system may further include a control system to manage the vanadium redox battery's absorption and power generation to control system stability and system frequency.

Abstract: An energy storage system includes a vanadium redox battery that interfaces with a control system to optimize performance and efficiency. The control system calculates optimal pump speeds, electrolyte temperature ranges, and charge and discharge rates. The control system instructs the vanadium redox battery to operate in accordance with the prescribed parameters. The control system further calculates optimal temperature ranges and charge and discharge rates for the vanadium redox battery.

Abstract: A power generation system includes a wind turbine generator and a vanadium redox battery to compensate for fluctuations in wind power. The wind turbine generator provides DC power that may be used to charge the vanadium redox battery. Generated DC power may also be used for power distribution and, if required, supplemented by DC power from the vanadium redox battery. The power generation system interfaces with a control system to optimize performance and efficiency.

Abstract: A power generation system includes a vanadium redox battery that interfaces with a control system to optimize performance and efficiency. The power generation system may include one or more wind turbine generators and one or more diesel fuel generators. The control system manages the vanadium redox battery's absorption and power generation to control system stability and system frequency. The control system further manages the operation of the wind turbine generators and diesel fuel generators to control system stability and voltage.