Patents by Inventor Timothy J. McMahon
Timothy J. McMahon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9056080Abstract: The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.Type: GrantFiled: June 17, 2013Date of Patent: June 16, 2015Assignee: Duke UniversityInventors: Mark W. Dewhirst, Jonathan S. Stamler, Timothy J. McMahon, Pierre D. Sonveaux
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Publication number: 20140161773Abstract: The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.Type: ApplicationFiled: June 17, 2013Publication date: June 12, 2014Inventors: Mark W. Dewhirst, Jonathan S. Stamler, Timothy J. McMahon, Pierre D. Sonveaux
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Patent number: 8466110Abstract: The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.Type: GrantFiled: April 18, 2012Date of Patent: June 18, 2013Assignee: Duke UniversityInventors: Mark W. Dewhirst, Jonathan S. Stamler, Timothy J. McMahon, Pierre Sonveaux
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Publication number: 20120225133Abstract: The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.Type: ApplicationFiled: April 18, 2012Publication date: September 6, 2012Applicant: Duke UniversityInventors: Mark W. Dewhirst, Jonathan S. Stamler, Timothy J. McMahon, Pierre Sonveaux
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Patent number: 8198241Abstract: The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.Type: GrantFiled: July 30, 2010Date of Patent: June 12, 2012Assignee: Duke UniversityInventors: Mark W. Dewhirst, Jonathan S. Stamler, Timothy J. McMahon, Pierre Sonveaux
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Patent number: 7887009Abstract: Methods and systems for attaching aircraft wings to fuselages are disclosed herein. An aircraft configured in accordance with an embodiment of the invention includes a fuselage and a wing. The wing includes a right wing portion extending outwardly from a right side portion of the fuselage and a left wing portion extending outwardly from a left side portion of the fuselage. In this embodiment, the right wing portion is fixedly attached to the left wing portion by a wing center section extending through at least a portion of the fuselage. The aircraft further includes a first pivotable link structurally attaching the wing center section to the right side portion of the fuselage, and a second pivotable link structurally attaching the wing center section to the left side portion of the fuselage.Type: GrantFiled: December 5, 2007Date of Patent: February 15, 2011Assignee: The Boeing CompanyInventors: Robert D. Keeler, Jr., Timothy J. McMahon
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Publication number: 20100298222Abstract: The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.Type: ApplicationFiled: July 30, 2010Publication date: November 25, 2010Applicant: Duke UniversityInventors: Mark W. Dewhirst, Jonathan S. Stamler, Timothy J. McMahon, Pierre D. Sonveaux
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Patent number: 7795219Abstract: The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.Type: GrantFiled: January 7, 2008Date of Patent: September 14, 2010Assignee: Duke UniversityInventors: Mark W. Dewhirst, Jonathan S. Stamler, Timothy J. McMahon, Pierre Sonveaux
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Patent number: 7790204Abstract: The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.Type: GrantFiled: January 7, 2008Date of Patent: September 7, 2010Assignee: Duke UniversityInventors: Mark W. Dewhirst, Jonathan S. Stamler, Timothy J. McMahon, Pierre Sonveaux
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Publication number: 20090146007Abstract: Methods and systems for attaching aircraft wings to fuselages are disclosed herein. An aircraft configured in accordance with an embodiment of the invention includes a fuselage and a wing. The wing includes a right wing portion extending outwardly from a right side portion of the fuselage and a left wing portion extending outwardly from a left side portion of the fuselage. In this embodiment, the right wing portion is fixedly attached to the left wing portion by a wing center section extending through at least a portion of the fuselage. The aircraft further includes a first pivotable link structurally attaching the wing center section to the right side portion of the fuselage, and a second pivotable link structurally attaching the wing center section to the left side portion of the fuselage.Type: ApplicationFiled: December 5, 2007Publication date: June 11, 2009Applicant: The Boeing CompanyInventors: Robert D. Keeler, JR., Timothy J. McMahon
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Publication number: 20080220095Abstract: Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O2 delivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.Type: ApplicationFiled: February 5, 2008Publication date: September 11, 2008Inventors: Jonathan S. Stamler, Joseph Bonaventura, John R. Pawloski, Timothy J. McMahon
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Patent number: 7338670Abstract: The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.Type: GrantFiled: April 13, 2006Date of Patent: March 4, 2008Assignee: Duke UniversityInventors: Mark W. Dewhirst, Jonathan S. Stamler, Timothy J. McMahon, Pierre Sonveaux
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Patent number: 7329543Abstract: Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O2 delivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.Type: GrantFiled: July 12, 2005Date of Patent: February 12, 2008Assignee: Duke UniversityInventors: Jonathan S. Stamler, Joseph Bonaventura, John R. Pawloski, Timothy J. McMahon
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Patent number: 6916471Abstract: Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O2 delivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.Type: GrantFiled: October 23, 2001Date of Patent: July 12, 2005Assignee: Duke UniversityInventors: Jonathan S. Stamler, Joseph Bonaventura, John R. Pawloski, Timothy J. McMahon
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Publication number: 20030008300Abstract: Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O2 delivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.Type: ApplicationFiled: October 23, 2001Publication date: January 9, 2003Applicant: Duke UniversityInventors: Jonathan S. Stamler, Joseph Bonaventura, John R. Pawloski, Timothy J. McMahon