Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: Systems and methods utilize an inertial navigation sub-system configured to determine a plurality of relative positions of the navigation system from a reference position based on the determined speed and/or acceleration and/or direction of the navigation system and/or changes thereto; and a position estimator sub-system configured to estimate the absolute position of the navigation system based on at least two received signals. A first track is defined based on the plurality of relative positions determined by the inertial navigation sub-system during a period of time and a second track is defined based on the plurality of estimates of the absolute position by calculating a best fit using the plurality of estimates of the absolute position, where the second track approximates a same shape as the first track.

Abstract: Systems and methods determine a position using uncoordinated signals containing timing information. The systems and methods use uncoordinated signals of opportunity, such as radio time signals, to determine a position of a receiver by determining the relative synchronization of the signals of opportunity at a known location and, at a later time and unknown locations, using trilateration or multilateration of the signals of opportunity to determine the position of the receiver.

Abstract: Systems and methods utilize an inertial navigation sub-system configured to determine a plurality of relative positions of the navigation system from a reference position based on the determined speed and/or acceleration and/or direction of the navigation system and/or changes thereto; and a position estimator sub-system configured to estimate the absolute position of the navigation system based on at least two received signals. A first track is defined based on the plurality of relative positions determined by the inertial navigation sub-system during a period of time and a second track is defined based on the plurality of estimates of the absolute position by calculating a best fit using the plurality of estimates of the absolute position, where the second track approximates a same shape as the first track.

Abstract: Systems and methods determine a position using uncoordinated signals containing timing information. The systems and methods use uncoordinated signals of opportunity, such as radio time signals, to determine a position of a receiver by determining the relative synchronization of the signals of opportunity at a known location and, at a later time and unknown locations, using trilateration or multilateration of the signals of opportunity to determine the position of the receiver.

Abstract: The present invention is directed to a system and method for simulating the interaction of a simulated vehicle with one or more simulated road surfaces. A computer modelling program is used to create a computer-based road surface model and a computer-based vehicle model. The computer-based vehicle model may include a body model, a chassis model, a suspension model, a wheel model and a tire model. A computer simulation engine program is operative with the computer-based road surface and vehicle models to selectively simulate the interaction therebetween and provide simulation data relative thereto. The simulation data may be used to identify high stress areas or low durability areas of the vehicle or to compute vehicle suspension parameters.

Abstract: The present invention is directed to a system and method for simulating the interaction of a simulated vehicle with one or more simulated road surfaces. A computer modelling program is used to create a computer-based road surface model and a computer-based vehicle model. The computer-based vehicle model may include a body model, a chassis model, a suspension model, a wheel model and a tire model. A computer simulation engine program is operative with the computer-based road surface and vehicle models to selectively simulate the interaction therebetween and provide simulation data relative thereto. The simulation data may be used to identify high stress areas or low durability areas of the vehicle or to compute vehicle suspension parameters.