Patents by Inventor Timothy James Larson

Timothy James Larson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240158837
    Abstract: Provided herein are methods of identifying genomic region(s) predictive of an outcome of treatment with a cell therapy and/or of a phenotype of function of the cells. In some embodiments, the methods include epigenetic and/or epigenomic analyses of the cells in connection with methods for preparing engineered cells for cell therapy and/or predicting response to a cell therapy, e.g., engineered cells for cell therapy. In some embodiments, the methods include steps to assess, characterize and analyze changes or modifications in an epigenetic property of gene region or regions, such as chromatin accessibility, nucleosome occupancy, histone modification, spatial chromosomal conformation, transcription factor occupancy and/or DNA methylation. In some embodiments, the epigenetic and/or epigenomic analysis includes determining the epigenetic properties of a cell, e.g., an engineered cell for cell therapy.
    Type: Application
    Filed: October 17, 2023
    Publication date: May 16, 2024
    Applicant: Juno Therapeutics, Inc.
    Inventors: Mark L. BONYHADI, David G. KUGLER, Timothy G. JOHNSTONE, Ronald James HAUSE, Jr., Lucas J. THOMPSON, Ryan P. LARSON
  • Patent number: 8195589
    Abstract: A method and apparatus are provided for dynamically determining a primary adapter in a heterogeneous N-way adapter configuration. Each of the adapters generates information about itself and exchanges the information with all other adapters. First a decision-making adapter is identified. Then the decision-making adapter compares the adapter-generated information of all the adapters and makes a decision determining the primary adapter. The decision-making adapter communicates the decision to all other adapters. The determined primary adapter assumes a role as the primary adapter and the other adapters assume a role as a secondary adapter.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: June 5, 2012
    Assignee: International Business Machines Corporation
    Inventors: Brian Eric Bakke, Robert Edward Galbraith, Brian James King, Timothy James Larson, William Joseph Maitland, Jr., Timothy Jerry Schimke
  • Patent number: 7979655
    Abstract: A method, computer program product and system for dynamically optimizing the limit and the thresholds of a write cache for a storage adapter connected to storage devices, includes measuring continually an overall locality of data in the write cache for the storage devices, calculating the limit of the write cache dynamically for each storage device using the overall locality and a device-related information, and calculating the threshold of the write cache dynamically for each storage device by combining a fair amount and a device-related additional amount.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: July 12, 2011
    Assignee: International Business Machines Corporation
    Inventors: Joseph Roger Edwards, Robert Edward Galbraith, Adrian Cuenin Gerhard, Timothy James Larson, William Joseph Maitland, Jr.
  • Patent number: 7925837
    Abstract: A method, computer program product and computer system for maintaining write cache and parity update footprint coherency in a multiple storage adaptor configuration for storage adaptors in a storage subsystem, which includes providing atomic updating of the storage adaptors and the attached disk drives, enabling runtime addition and runtime subtraction of a storage adaptor in the multiple storage adaptor configuration, and maintaining write cache and parity update footprint coherency using atomic updating, runtime addition and runtime subtraction of a storage adaptor.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: April 12, 2011
    Assignee: International Business Machines Corporation
    Inventors: Joseph Roger Edwards, Robert Edward Galbraith, Adrian Cuenin Gerhard, Timothy James Larson, William Joseph Maitland, Jr.
  • Publication number: 20090228660
    Abstract: A method, computer program product and system for dynamically optimizing the limit and the thresholds of a write cache for a storage adapter connected to storage devices, includes measuring continually an overall locality of data in the write cache for the storage devices, calculating the limit of the write cache dynamically for each storage device using the overall locality and a device-related information, and calculating the threshold of the write cache dynamically for each storage device by combining a fair amount and a device-related additional amount.
    Type: Application
    Filed: March 4, 2008
    Publication date: September 10, 2009
    Inventors: Joseph Roger Edwards, Robert Edward Galbraith, Adrian Cuenin Gerhard, Timothy James Larson, William Joseph Maitland, JR.
  • Publication number: 20090228646
    Abstract: A method, computer program product and computer system for maintaining write cache and parity update footprint coherency in a multiple storage adaptor configuration for storage adaptors in a storage subsystem, which includes providing atomic updating of the storage adaptors and the attached disk drives, enabling runtime addition and runtime subtraction of a storage adaptor in the multiple storage adaptor configuration, and maintaining write cache and parity update footprint coherency using atomic updating, runtime addition and runtime subtraction of a storage adaptor.
    Type: Application
    Filed: March 4, 2008
    Publication date: September 10, 2009
    Inventors: Joseph Roger Edwards, Robert Edward Galbraith, Adrian Cuenin Gerhard, Timothy James Larson, William Joseph Maitland, JR.
  • Patent number: 7493370
    Abstract: A method and apparatus are provided for dynamically determining a primary adapter in a heterogeneous N-way adapter configuration. Each of the adapters generates information about itself and exchanges the information with all other adapters. First a decision-making adapter is identified. Then the decision-making adapter compares the adapter-generated information of all the adapters and makes a decision determining the primary adapter. The decision-making adapter communicates the decision to all other adapters. The determined primary adapter assumes a role as the primary adapter and the other adapters assume a role as a secondary adapter.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: February 17, 2009
    Assignee: International Business Machines Corporation
    Inventors: Brian Eric Bakke, Robert Edward Galbraith, Brian James King, Timothy James Larson, William Joseph Maitland, Jr., Timothy Jerry Schimke
  • Publication number: 20080243743
    Abstract: A method and apparatus are provided for dynamically determining a primary adapter in a heterogeneous N-way adapter configuration. Each of the adapters generates information about itself and exchanges the information with all other adapters. First a decision-making adapter is identified. Then the decision-making adapter compares the adapter-generated information of all the adapters and makes a decision determining the primary adapter. The decision-making adapter communicates the decision to all other adapters. The determined primary adapter assumes a role as the primary adapter and the other adapters assume a role as a secondary adapter.
    Type: Application
    Filed: June 11, 2008
    Publication date: October 2, 2008
    Applicant: International Business Machines Corporation
    Inventors: Brian Eric Bakke, Robert Edward Galbraith, Brain James King, Timothy James Larson, William Joseph Maitland, Timothy Jerry Schimke