Abstract: Provided herein are methods of identifying genomic region(s) predictive of an outcome of treatment with a cell therapy and/or of a phenotype of function of the cells. In some embodiments, the methods include epigenetic and/or epigenomic analyses of the cells in connection with methods for preparing engineered cells for cell therapy and/or predicting response to a cell therapy, e.g., engineered cells for cell therapy. In some embodiments, the methods include steps to assess, characterize and analyze changes or modifications in an epigenetic property of gene region or regions, such as chromatin accessibility, nucleosome occupancy, histone modification, spatial chromosomal conformation, transcription factor occupancy and/or DNA methylation. In some embodiments, the epigenetic and/or epigenomic analysis includes determining the epigenetic properties of a cell, e.g., an engineered cell for cell therapy.

Abstract: A method and apparatus are provided for dynamically determining a primary adapter in a heterogeneous N-way adapter configuration. Each of the adapters generates information about itself and exchanges the information with all other adapters. First a decision-making adapter is identified. Then the decision-making adapter compares the adapter-generated information of all the adapters and makes a decision determining the primary adapter. The decision-making adapter communicates the decision to all other adapters. The determined primary adapter assumes a role as the primary adapter and the other adapters assume a role as a secondary adapter.

Abstract: A method, computer program product and system for dynamically optimizing the limit and the thresholds of a write cache for a storage adapter connected to storage devices, includes measuring continually an overall locality of data in the write cache for the storage devices, calculating the limit of the write cache dynamically for each storage device using the overall locality and a device-related information, and calculating the threshold of the write cache dynamically for each storage device by combining a fair amount and a device-related additional amount.

Abstract: A method, computer program product and computer system for maintaining write cache and parity update footprint coherency in a multiple storage adaptor configuration for storage adaptors in a storage subsystem, which includes providing atomic updating of the storage adaptors and the attached disk drives, enabling runtime addition and runtime subtraction of a storage adaptor in the multiple storage adaptor configuration, and maintaining write cache and parity update footprint coherency using atomic updating, runtime addition and runtime subtraction of a storage adaptor.

Abstract: A method, computer program product and system for dynamically optimizing the limit and the thresholds of a write cache for a storage adapter connected to storage devices, includes measuring continually an overall locality of data in the write cache for the storage devices, calculating the limit of the write cache dynamically for each storage device using the overall locality and a device-related information, and calculating the threshold of the write cache dynamically for each storage device by combining a fair amount and a device-related additional amount.

Abstract: A method, computer program product and computer system for maintaining write cache and parity update footprint coherency in a multiple storage adaptor configuration for storage adaptors in a storage subsystem, which includes providing atomic updating of the storage adaptors and the attached disk drives, enabling runtime addition and runtime subtraction of a storage adaptor in the multiple storage adaptor configuration, and maintaining write cache and parity update footprint coherency using atomic updating, runtime addition and runtime subtraction of a storage adaptor.

Abstract: A method and apparatus are provided for dynamically determining a primary adapter in a heterogeneous N-way adapter configuration. Each of the adapters generates information about itself and exchanges the information with all other adapters. First a decision-making adapter is identified. Then the decision-making adapter compares the adapter-generated information of all the adapters and makes a decision determining the primary adapter. The decision-making adapter communicates the decision to all other adapters. The determined primary adapter assumes a role as the primary adapter and the other adapters assume a role as a secondary adapter.

Abstract: A method and apparatus are provided for dynamically determining a primary adapter in a heterogeneous N-way adapter configuration. Each of the adapters generates information about itself and exchanges the information with all other adapters. First a decision-making adapter is identified. Then the decision-making adapter compares the adapter-generated information of all the adapters and makes a decision determining the primary adapter. The decision-making adapter communicates the decision to all other adapters. The determined primary adapter assumes a role as the primary adapter and the other adapters assume a role as a secondary adapter.