Patents by Inventor Timothy Kelliher
Timothy Kelliher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240099213Abstract: Provided here are methods of using a mutated patatin-like phospholipase II? (“pPLAII?,” renamed here MATRILINEAL) to induce haploid induction in plants, cloning a pPLAII? to induce haploid induction in plants, and genetically engineering a plant to contain a mutated pPLAII?. Also provided are methods of applying topical and spray chemicals, lipids, and RNAi molecules to plants during pollination in order to induce haploid production. Further provided are methods of chemically treating plants during pollination to induce haploids while also reducing embryo abortion and increasing seed set.Type: ApplicationFiled: November 30, 2023Publication date: March 28, 2024Applicant: Syngenta Participations AGInventors: Timothy Kelliher, Satya Chintamanani, Brent Delzer, Michael L Nuccio, Robert Arthur Dietrich, Suresh Babu Kadaru, Todd Lee Warner, William Paul Bullock
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Patent number: 11840697Abstract: Provided are isolated cDNAs comprising a nucleotide sequence having at least 90% identity to SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 52 or SEQ ID NO: 53. Also provided are expression cassettes; vectors; transgenic plant cells; plants, plant parts, and seeds; isolated polypeptides; amplicons and informative fragments of the presently disclosed nucleic acids; compositions that include amplification primer pairs; methods for producing plants that exhibit HI; methods for identifying the presence or absence of an allele associated with HI in a plant; methods for introgressing Haploid-inducing nucleotide sequences into plants; and methods for selecting parental plants predicted to produce progeny generations with plants that exhibit Haploid Induction trait.Type: GrantFiled: February 12, 2021Date of Patent: December 12, 2023Assignee: Syngenta Participations AGInventors: Timothy Kelliher, Satya Chintamanani, Brent Delzer, Michael L Nuccio, Robert Arthur Dietrich, Suresh Babu Kadaru, Todd Lee Warner, William Paul Bullock
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Publication number: 20230227836Abstract: The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it encodes cellular machinery capable of editing genes. The transformed haploid inducing line is used as a parent in a cross between two plants. During pollination, the parental gametes fuse to form an embryo; and the gene editing machinery is also delivered to the embryo at this time. During embryonic development, one set of parental chromosomes are lost, and the gene editing machinery operates on the remaining set of chromosomes. Thus, at least one haploid progeny with edited genes is produced from the cross.Type: ApplicationFiled: November 30, 2022Publication date: July 20, 2023Applicant: Syngenta Crop Protection AGInventors: Qiudeng Que, Timothy Kelliher
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Publication number: 20230060937Abstract: The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it encodes cellular machinery capable of editing genes. The transformed haploid inducing line is used as a parent in a cross between two plants. During pollination, the parental gametes fuse to form an embryo; and the gene editing machinery is also delivered to the embryo at this time. During embryonic development, one set of parental chromosomes are lost, and the gene editing machinery operates on the remaining set of chromosomes. Thus, at least one haploid progeny with edited genes is produced from the cross. The disclosure is also directed to methods of testing an edited haploid plant progeny for the presence of a first plant's genomic material.Type: ApplicationFiled: December 17, 2019Publication date: March 2, 2023Applicant: Syngenta Participations AGInventors: Timothy Kelliher, Qiudeng Que
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Publication number: 20220192120Abstract: Provided here are methods of using a mutated patatin-like phospholipase II? (“pPLAII?,” renamed here MATRILINEAL) to induce haploid induction in plants, cloning a pPLAII? to induce haploid induction in plants, and genetically engineering a plant to contain a mutated pPLAII?. Also provided are methods of applying topical and spray chemicals, lipids, and RNAi molecules to plants during pollination in order to induce haploid production. Further provided are methods of chemically treating plants during pollination to induce haploids while also reducing embryo abortion and increasing seed set.Type: ApplicationFiled: March 10, 2022Publication date: June 23, 2022Applicant: Syngenta Participations AGInventors: Timothy Kelliher, Satya Chintamanani, Brent Delzer, Michael L Nuccio, Robert Arthur Dietrich, Suresh Babu KADARU, Todd Lee Warner, William Paul Bullock
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Publication number: 20220145312Abstract: Systems and methods for producing a plurality of unique edits in a plant's T1 seed. In one example, a method comprises transforming at least one expression cassette into a plant cell or a plant tissue. The at least one expression cassette may comprise a nucleic acid that encodes a DNA modification enzyme; optionally, a nucleic acid that encodes at least one guide RNA (gRNA); and a floral mosaic (FMOS) regulatory sequence, wherein the FMOS regulatory sequence (i) mediates expression of the DNA modification enzyme in at least one of a floral primordia cell and a floral reproductive organ, and (ii) mediates a plurality of edits in the at least one of the floral primordia and the floral reproductive organ. The method may also include regenerating the plant cell or plant tissue into a T0 plant having a plurality of T1 seed, wherein the T1 seed contain a plurality of unique edits.Type: ApplicationFiled: February 24, 2020Publication date: May 12, 2022Applicant: Syngenta Crop Protection AGInventors: Timothy Kelliher, Jiang Li, Julie Leonard Green, Zhongying Chen, Wan Shi, Guozhu Tang
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Patent number: 11304392Abstract: Provided here are methods of using a mutated patatin-like phospholipase II? (“pPLAII?,” renamed here MATRILINEAL) to induce haploid induction in plants, cloning a pPLAII? to induce haploid induction in plants, and genetically engineering a plant to contain a mutated pPLAII?. Also provided are methods of applying topical and spray chemicals, lipids, and RNAi molecules to plants during pollination in order to induce haploid production. Further provided are methods of chemically treating plants during pollination to induce haploids while also reducing embryo abortion and increasing seed set.Type: GrantFiled: September 6, 2019Date of Patent: April 19, 2022Assignee: Syngenta Participations AGInventors: Timothy Kelliher, Satya Chintamanani, Brent Delzer, Michael L Nuccio, Robert Arthur Dietrich, Suresh Babu Kadaru, Todd Lee Warner, William Paul Bullock
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Publication number: 20210163971Abstract: Provided are isolated cDNAs comprising a nucleotide sequence having at least 90% identity to SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 52 or SEQ ID NO: 53. Also provided are expression cassettes; vectors; transgenic plant cells; plants, plant parts, and seeds; isolated polypeptides; amplicons and informative fragments of the presently disclosed nucleic acids; compositions that include amplification primer pairs; methods for producing plants that exhibit HI; methods for identifying the presence or absence of an allele associated with HI in a plant; methods for introgressing Haploid-inducing nucleotide sequences into plants; and methods for selecting parental plants predicted to produce progeny generations with plants that exhibit Haploid Induction trait.Type: ApplicationFiled: February 12, 2021Publication date: June 3, 2021Applicant: Syngenta Participations AGInventors: Timothy Kelliher, Satya Chintamanani, Brent Delzer, Michael L Nuccio, Robert Arthur Dietrich, Suresh Babu KADARU, Todd Lee Warner, William Paul Bullock
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Patent number: 10954523Abstract: Provided are isolated cDNAs comprising a nucleotide sequence having at least 90% identity to SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 52 or SEQ ID NO: 53. Also provided are expression cassettes; vectors; transgenic plant cells; plants, plant parts, and seeds; isolated polypeptides; amplicons and informative fragments of the presently disclosed nucleic acids; compositions that include amplification primer pairs; methods for producing plants that exhibit HI; methods for identifying the presence or absence of an allele associated with HI in a plant; methods for introgressing Haploid—inducing nucleotide sequences into plants; and methods for selecting parental plants predicted to produce progeny generations with plants that exhibit Haploid Induction trait.Type: GrantFiled: December 13, 2018Date of Patent: March 23, 2021Assignee: Syngenta Participations AGInventors: Timothy Kelliher, Satya Chintamanani, Brent Delzer, Michael L Nuccio, Robert Arthur Dietrich, Suresh Babu Kadaru, Todd Lee Warner, William Paul Bullock
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Publication number: 20200080097Abstract: The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it encodes cellular machinery capable of editing genes. The transformed haploid inducing line is used as a parent in a cross between two plants. During pollination, the parental gametes fuse to form an embryo; and the gene editing machinery is also delivered to the embryo at this time. During embryonic development, one set of parental chromosomes are lost, and the gene editing machinery operates on the remaining set of chromosomes. Thus, at least one haploid progeny with edited genes is produced from the cross.Type: ApplicationFiled: November 8, 2019Publication date: March 12, 2020Applicant: Syngenta Participations AGInventors: Qiudeng Que, Timothy Kelliher
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Publication number: 20200060110Abstract: Provided here are methods of using a mutated patatin-like phospholipase II? (“pPLAII?,” renamed here MATRILINEAL) to induce haploid induction in plants, cloning a pPLAII? to induce haploid induction in plants, and genetically engineering a plant to contain a mutated pPLAII?. Also provided are methods of applying topical and spray chemicals, lipids, and RNAi molecules to plants during pollination in order to induce haploid production. Further provided are methods of chemically treating plants during pollination to induce haploids while also reducing embryo abortion and increasing seed set.Type: ApplicationFiled: September 6, 2019Publication date: February 27, 2020Applicant: Syngenta Participations AGInventors: Timothy Kelliher, Satya Chintamanani, Brent Delzer, Michael L Nuccio, Robert Arthur Dietrich, Suresh Babu Kadaru, Todd Lee Warner, William Paul Bullock
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Patent number: 10519456Abstract: The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it encodes cellular machinery capable of editing genes. The transformed haploid inducing line is used as a parent in a cross between two plants. During pollination, the parental gametes fuse to form an embryo; and the gene editing machinery is also delivered to the embryo at this time. During embryonic development, one set of parental chromosomes are lost, and the gene editing machinery operates on the remaining set of chromosomes. Thus, at least one haploid progeny with edited genes is produced from the cross.Type: GrantFiled: January 11, 2019Date of Patent: December 31, 2019Assignee: Syngenta Participations AGInventors: Qiudeng Que, Timothy Kelliher
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Publication number: 20190376075Abstract: The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it encodes cellular machinery capable of editing genes. The transformed haploid inducing line is used as a parent in a cross between two plants. During pollination, the parental gametes fuse to form an embryo; and the gene editing machinery is also delivered to the embryo at this time. During embryonic development, one set of parental chromosomes are lost, and the gene editing machinery operates on the remaining set of chromosomes. Thus, at least one haploid progeny with edited genes is produced from the cross.Type: ApplicationFiled: December 4, 2017Publication date: December 12, 2019Applicant: Syngenta Participations AGInventors: Qiudeng Que, Timothy Kelliher
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Patent number: 10448588Abstract: Provided here are methods of using a mutated patatin-like phospholipase II? (“pPLAII?,” renamed here MATRILINEAL) to induce haploid induction in plants, cloning a pPLAII? to induce haploid induction in plants, and genetically engineering a plant to contain a mutated pPLAII?. Also provided are methods of applying topical and spray chemicals, lipids, and RNAi molecules to plants during pollination in order to induce haploid production. Further provided are methods of chemically treating plants during pollination to induce haploids while also reducing embryo abortion and increasing seed set.Type: GrantFiled: November 17, 2016Date of Patent: October 22, 2019Assignee: Syngenta Participations AGInventors: Satya Chintamanani, Timothy Kelliher, Brent Delzer, Michael Nuccio, Robert Arthur Dietrich, Suresh Babu Kadaru, Todd Warner, William Paul Bullock
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Patent number: 10285348Abstract: The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it encodes cellular machinery capable of editing genes. The transformed haploid inducing line is used as a parent in a cross between two plants. During pollination, the parental gametes fuse to form an embryo; and the gene editing machinery is also delivered to the embryo at this time. During embryonic development, one set of parental chromosomes are lost, and the gene editing machinery operates on the remaining set of chromosomes. Thus, at least one haploid progeny with edited genes is produced from the cross.Type: GrantFiled: February 21, 2018Date of Patent: May 14, 2019Assignee: Syngenta Participations AGInventors: Timothy Kelliher, Qiudeng Que
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Publication number: 20190136250Abstract: The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it encodes cellular machinery capable of editing genes. The transformed haploid inducing line is used as a parent in a cross between two plants. During pollination, the parental gametes fuse to form an embryo; and the gene editing machinery is also delivered to the embryo at this time. During embryonic development, one set of parental chromosomes are lost, and the gene editing machinery operates on the remaining set of chromosomes. Thus, at least one haploid progeny with edited genes is produced from the cross.Type: ApplicationFiled: January 11, 2019Publication date: May 9, 2019Applicant: Syngenta Participations AGInventors: Qiudeng Que, Timothy Kelliher
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Publication number: 20190100763Abstract: Provided are isolated cDNAs comprising a nucleotide sequence having at least 90% identity to SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 52 or SEQ ID NO: 53. Also provided are expression cassettes; vectors; transgenic plant cells; plants, plant parts, and seeds; isolated polypeptides; amplicons and informative fragments of the presently disclosed nucleic acids; compositions that include amplification primer pairs; methods for producing plants that exhibit HI; methods for identifying the presence or absence of an allele associated with HI in a plant; methods for introgressing Haploid—inducing nucleotide sequences into plants; and methods for selecting parental plants predicted to produce progeny generations with plants that exhibit Haploid Induction trait.Type: ApplicationFiled: December 13, 2018Publication date: April 4, 2019Applicant: Syngenta Participations AGInventors: Timothy Kelliher, Satya Chintamanani, Brent Delzer, Michael L. Nuccio, Robert Arthur Dietrich, Suresh Babu KADARU, Todd Lee Warner, William Paul Bullock
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Patent number: 10190125Abstract: Provided are isolated cDNAs comprising a nucleotide sequence having at least 90% identity to SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 52 or SEQ ID NO: 53. Also provided are expression cassettes; vectors; transgenic plant cells; plants, plant parts, and seeds; isolated polypeptides; amplicons and informative fragments of the presently disclosed nucleic acids; compositions that include amplification primer pairs; methods for producing plants that exhibit HI; methods for identifying the presence or absence of an allele associated with HI in a plant; methods for introgressing Haploid-inducing nucleotide sequences into plants; and methods for selecting parental plants predicted to produce progeny generations with plants that exhibit Haploid Induction trait.Type: GrantFiled: May 4, 2017Date of Patent: January 29, 2019Assignee: Syngenta Participations AGInventors: Satya Chintamanani, Timothy Kelliher, Brent Delzer, Michael L. Nuccio, Robert Arthur Dietrich, Suresh Babu Kadaru, Todd Lee Warner, William Paul Bullock
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Publication number: 20180332790Abstract: Provided here are methods of using a mutated patatin-like phospholipase II? (“pPLAII?,” renamed here MATRILINEAL) to induce haploid induction in plants, cloning a pPLAII? to induce haploid induction in plants, and genetically engineering a plant to contain a mutated pPLAII?. Also provided are methods of applying topical and spray chemicals, lipids, and RNAi molecules to plants during pollination in order to induce haploid production. Further provided are methods of chemically treating plants during pollination to induce haploids while also reducing embryo abortion and increasing seed set.Type: ApplicationFiled: November 17, 2016Publication date: November 22, 2018Applicant: Syngenta Participations AGInventors: Timothy KELLIHER, Brent DELZER, Satya CHINTAMANANI, David Stewart SKIBBE, Zhongying CHEN, Dakota STARR, Sebastian Volker WENDEBORN, Mark LEDSON, Jeffrey David FOWLER
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Publication number: 20180273963Abstract: The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it encodes cellular machinery capable of editing genes. The transformed haploid inducing line is used as a parent in a cross between two plants. During pollination, the parental gametes fuse to form an embryo; and the gene editing machinery is also delivered to the embryo at this time. During embryonic development, one set of parental chromosomes are lost, and the gene editing machinery operates on the remaining set of chromosomes. Thus, at least one haploid progeny with edited genes is produced from the cross.Type: ApplicationFiled: February 21, 2018Publication date: September 27, 2018Applicant: Syngenta Participations AGInventors: Timothy KELLIHER, Qiudeng QUE