Patents by Inventor Timothy Leaver
Timothy Leaver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11938454Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.Type: GrantFiled: December 18, 2020Date of Patent: March 26, 2024Assignee: The University of British ColumbiaInventors: Euan Ramsay, Robert James Taylor, Timothy Leaver, Andre Wild, Kevin Ou, Colin Walsh
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Publication number: 20230256436Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.Type: ApplicationFiled: April 6, 2023Publication date: August 17, 2023Applicant: The University of British ColumbiaInventors: Pieter R. Cullis, Igor V. Jigaltsev, Robert James Taylor, Timothy Leaver, Andre Wild, Nathan Maurice Belliveau
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Patent number: 11648556Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.Type: GrantFiled: October 1, 2020Date of Patent: May 16, 2023Assignee: The University of British ColumbiaInventors: Pieter R. Cullis, Igor V. Jigaltsev, Robert James Taylor, Timothy Leaver, Andre Wild, Nathan Maurice Belliveau
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Publication number: 20210291179Abstract: A “smart ” instrument for mixing (100), a microfluidic chip (50), and a system wherein they are used to prepare formulations is provided. The microfluidic chip comprises microchannels and a programmable data component. The system achieves optimal formulations for RNA, antisense, peptides and small molecules in the hands of even novice users.Type: ApplicationFiled: June 7, 2021Publication date: September 23, 2021Applicant: Precision NanoSystems IncInventors: Andre Wild, Timothy Leaver, Robert James Taylor, Euan Ramsay, Nicolas Klaassen, Shao Fang Shannon Chang, Keara Marshall
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Patent number: 11059039Abstract: A “smart” instrument for mixing (100), a microfluidic chip (50), and a system wherein they are used to prepare formulations is provided. The microfluidic chip comprises microchannels and a programmable data component. The system achieves optimal formulations for RNA, antisense, peptides and small molecules in the hands of even novice users.Type: GrantFiled: June 30, 2017Date of Patent: July 13, 2021Assignee: Precision NanoSystems Inc.Inventors: Andre Wild, Timothy Leaver, Robert James Taylor, Euan Ramsay, Nicolas Klaassen, Shao Fang Shannon Chang, Keara Marshall
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Publication number: 20210113974Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.Type: ApplicationFiled: December 18, 2020Publication date: April 22, 2021Applicant: The University of British ColumbiaInventors: Euan Ramsay, Robert James Taylor, Timothy Leaver, Andre Wild, Kevin Ou, Colin Walsh
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Publication number: 20210023514Abstract: Disclosed herein are continuous flow systems having bifurcated fluidic flow mixers. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). DVBMs utilize Dean vortexing and bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing.Type: ApplicationFiled: October 7, 2020Publication date: January 28, 2021Applicant: The University of British ColumbiaInventors: Euan Ramsay, Robert James Taylor, Timothy Leaver, Andre Wild, Kevin Ou, Colin Walsh
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Publication number: 20210023556Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.Type: ApplicationFiled: October 1, 2020Publication date: January 28, 2021Applicant: The University of British ColumbiaInventors: Pieter R. Cullis, Igor V. Jigaltsev, Robert James Taylor, Timothy Leaver, Andre Wild, Nathan Maurice Belliveau
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Patent number: 10843194Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.Type: GrantFiled: March 21, 2018Date of Patent: November 24, 2020Assignee: The University of British ColumbiaInventors: Pieter R. Cullis, Igor V. Jigaltsev, Robert James Taylor, Timothy Leaver, Andre Wild, Nathan Maurice Belliveau
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Patent number: 10835878Abstract: Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.Type: GrantFiled: May 14, 2020Date of Patent: November 17, 2020Assignee: The University of British ColumbiaInventors: Andre Wild, Timothy Leaver, Robert James Taylor
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Publication number: 20200269201Abstract: Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.Type: ApplicationFiled: May 14, 2020Publication date: August 27, 2020Applicant: The University of British ColumbiaInventors: Andre Wild, Timothy Leaver, Robert James Taylor
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Patent number: 10688456Abstract: Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.Type: GrantFiled: August 13, 2018Date of Patent: June 23, 2020Assignee: The University of British ColumbiaInventors: Andre Wild, Timothy Leaver, Robert James Taylor
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Publication number: 20200139321Abstract: The present invention provides a microfluidic mixing platform having a bulk, the platform including an inlet well, a microchannel, a passive capillary valve a mixing feature and an outlet. The passive capillary valve prevents unwanted capillary flow along the microchannel. The passive capillary valve comprises a widening of the microchannel relative to the direction of fluid flow, and the angle has a graduated profile. The mixing platform bulk comprises a rigid matrix capable of machine manufacture. A method of preventing backflow in a microfluidic mixer is also provided.Type: ApplicationFiled: January 17, 2018Publication date: May 7, 2020Applicant: Precision Nanosystems Inc.Inventors: Andre Wild, Shao Fang Shannon Chang, Timothy Leaver
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Patent number: 10597291Abstract: The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.Type: GrantFiled: October 27, 2017Date of Patent: March 24, 2020Assignee: The University of British ColumbiaInventors: Andre Wild, Timothy Leaver, Colin Walsh, Gesine Heuck, Anitha Thomas, Aysha Ansari, Kevin Ou, Robert James Taylor, Euan Ramsay
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Publication number: 20200023358Abstract: A “smart” instrument for mixing (100), a microfluidic chip (50), and a system wherein they are used to prepare formulations is provided. The microfluidic chip comprises microchannels and a programmable data component. The system achieves optimal formulations for RNA, antisense, peptides and small molecules in the hands of even novice users.Type: ApplicationFiled: June 30, 2017Publication date: January 23, 2020Applicant: Precision Nanosystems Inc.Inventors: Andre Wild, Timothy Leaver, Robert James Taylor, Euan Ramsay, Nicolas Klaassen, Shao Fang Shannon Chang, Keara Marshall
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Publication number: 20190307689Abstract: Transfection reagent composition, lipid nanoparticles prepared from the transfection reagent composition, kits that include the transfection reagent composition, and methods for making and using lipid nanoparticles prepared from the transfection reagent composition. Lipids when dispersed in aqueous media readily form liposomes, such as unilamellar vesicles and multilamellar vesicles. Liposomes have been used successfully to encapsulate and deliver a wide range of chemicals including nucleic acids, proteins and, small molecule drugs, to cells.Type: ApplicationFiled: June 21, 2019Publication date: October 10, 2019Applicant: The University of British ColumbiaInventors: Euan Ramsay, R. James Taylor, Colin Walsh, Nathan M. Belliveau, Pieter R. Cullis, Timothy Leaver, Andre Wild
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Patent number: 10342760Abstract: Transfection reagent composition, lipid nanoparticles prepared from the transfection reagent composition, kits that include the transfection reagent composition, and methods for making and using lipid nanoparticles prepared from the transfection reagent composition. Lipids when dispersed in aqueous media readily form liposomes, such as unilamellar vesicles and multilamellar vesicles. Liposomes have been used successfully to encapsulate and deliver a wide range of chemicals including nucleic acids, proteins and small molecule drugs, to cells.Type: GrantFiled: March 14, 2014Date of Patent: July 9, 2019Assignee: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Euan Ramsay, R. James Taylor, Colin Walsh, Nathan M. Belliveau, Pieter R. Cullis, Timothy Leaver, Andre Wild
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Publication number: 20190076372Abstract: Methods and devices for making particles at small volumes.Type: ApplicationFiled: November 8, 2018Publication date: March 14, 2019Applicant: The University of British ColumbiaInventors: Colin Walsh, Andre Wild, Robert James Taylor, Timothy Leaver, Kevin Ou, Euan Ramsay, Aysha Ansari
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Patent number: 10159652Abstract: Methods and devices for making particles at small volumes.Type: GrantFiled: October 16, 2014Date of Patent: December 25, 2018Assignee: The University of British ColumbiaInventors: Colin Walsh, Andre Wild, Robert James Taylor, Timothy Leaver, Kevin Ou, Euan Ramsay, Aysha Ansari
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Patent number: D849265Type: GrantFiled: April 21, 2017Date of Patent: May 21, 2019Assignee: PRECISION NANOSYSTEMS INCInventors: Andre Wild, Timothy Leaver, Shao Fang Shannon Chang, Niklaus Alexander Andre, Rodney Paul Bucknell, Andrew Robert Patterson, Phillip Higgins, Thomas William Cameron Debenham