Patents by Inventor Timothy Lee Stuk

Timothy Lee Stuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING A NOVEL PHENICOL ANTIBACTERIAL AGENT
    Publication number: 20210355086
    Abstract: The present invention provides a novel process for preparing a diastereomeric mixture of the phenicol of Formula (1), its use for the treatment of bacterial infections in animals, and veterinary compositions containing the Formula (1) compound, diastereomers thereof, and veterinary acceptable salts thereof.
    Type: Application
    Filed: September 23, 2019
    Publication date: November 18, 2021
    Inventors: Randall Lee DeJong, Gregory Lee Karrick, Timothy Lee Stuk
  • Process for preparing 7H-pyrrolo[2,3-D]pyrimidine compounds
    Patent number: 9926327
    Abstract: Described herein are improved processes for the preparation of the 7H-pyrrolo[2,3-d]pyrimidine compound, N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methanesulfonamide, intermediates thereof, and veterinary acceptable salts thereof.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: March 27, 2018
    Assignee: Zoetis Services LLC
    Inventors: Timothy Lee Stuk, Denis Billen, Valerie Sue Westrick, Vageesha Warnajith Liyana Gunawardana
  • PROCESS FOR PREPARING 7H-PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS
    Publication number: 20170233397
    Abstract: Described herein are improved processes for the preparation of the 7H-pyrrolo[2,3-d]pyrimidine compound, N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methanesulfonamide, intermediates thereof, and veterinary acceptable salts thereof.
    Type: Application
    Filed: February 7, 2017
    Publication date: August 17, 2017
    Inventors: Timothy Lee Stuk, Denis Billen, Valerie Sue Westrick, Vageesha Warnajith Liyana Gunawardana
  • PROCESS FOR THE PREPARATION OF CHIRAL ISOXAZOLINE AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS
    Publication number: 20140371464
    Abstract: The invention recites a chiral process for the synthesis of isoxazoline azetidine phenyl substituted derivatives of Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, processes for making, and their use as a parasiticide in an animal.
    Type: Application
    Filed: January 29, 2013
    Publication date: December 18, 2014
    Inventors: Denis Billen, Sean David William Greenwood, Timothy Lee Stuk
  • Spirocyclic isoxazoline derivatives as antiparasitic agents
    Patent number: 8466115
    Abstract: The invention recites spirocyclic isoxazoline derivatives of Formula (V.1), Formula (V.2), Formula (V.1.1), and Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables A, V, Z, W1, W2, W3, W, Y, X, R1a, R1b, R1c, R2, R3, R4, n, and “” are as described herein.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: June 18, 2013
    Assignee: Zoetis LLC
    Inventors: Michael Curtis, Sanjay Menon, Valerie A. Vaillancourt, Nathan Anthony Logan Chubb, Denis Billen, Sean David William Greenwood, Timothy Lee Stuk
  • SPIROCYCLIC ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS
    Publication number: 20120232026
    Abstract: The invention recites spirocyclic isoxazoline derivatives of Formula (V.1), Formula (V.2), Formula (V.1.1), and Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables A, V, Z, W1, W2, W3, W, Y, X, R1a, R1b, R1c, R2, R3, R4, n, and “” are as described herein.
    Type: Application
    Filed: March 8, 2012
    Publication date: September 13, 2012
    Applicant: PFIZER INC.
    Inventors: Michael Curtis, Sanjay Menon, Valerie A. Vaillancourt, Nathan Anthony Logan Chubb, Denis Billen, Sean David William Greenwood, Timothy Lee Stuk
  • Process for the preparation of asenapine and intermediate products used in said process
    Patent number: 8227623
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: July 24, 2012
    Assignee: MSD Oss B.V.
    Inventors: Gerardus Johannes Kemperman, Timothy Lee Stuk, Jacobus Johannes Maria Van Der Linden
  • Process for the Preparation of Asenapine and Intermediate Products Used in Said Process
    Publication number: 20100234618
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Application
    Filed: May 24, 2010
    Publication date: September 16, 2010
    Applicant: N.V. Organon
    Inventors: Gerardus Johannes Kemperman, Timothy Lee Stuk, Jacobus Johannes Maria Van Der Linden
  • Process for the preparation of asenapine and intermediate products used in said process
    Patent number: 7750167
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: July 6, 2010
    Assignee: N.V. Organon
    Inventors: Gerardus Johannes Kemperman, Timothy Lee Stuk, Jacobus Johannes Maria Van Der Linden
  • Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide
    Patent number: 7371855
    Abstract: An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: May 13, 2008
    Assignee: Warner-Lambert Company
    Inventors: Jade Douglas Nelson, Michael Gerard Pamment, Timothy Lee Stuk
  • Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide
    Patent number: 7361771
    Abstract: An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: April 22, 2008
    Assignee: Warner-Lambert Company
    Inventors: Donald Eugene Butler, Randall Lee Dejong, Jade Douglas Nelson, Michael Gerard Pamment, Timothy Lee Stuk
  • PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS
    Publication number: 20080009619
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Application
    Filed: July 3, 2007
    Publication date: January 10, 2008
    Applicant: N.V. Organon
    Inventors: Gerardus Johannes Kemperman, Timothy Lee Stuk, Jacobus Johannes Maria Van Der Linden
  • Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone)
    Patent number: 7304158
    Abstract: The present invention relates to methods for making racemic 2-(7-chloro -1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone and (+)-2-(7 -chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: December 4, 2007
    Assignee: Indevus Pharmaceuticals, Inc.
    Inventors: Sandra Marie Jennings, Timothy Lee Stuk
  • Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide
    Patent number: 7183408
    Abstract: An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: February 27, 2007
    Assignee: Warner-Lambert Company, LLC
    Inventors: Donald Eugene Butler, Randall Lee DeJong, Jade Douglas Nelson, Michael Gerard Pamment, Timothy Lee Stuk
  • Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2oxo-hexyl)-1-isoidolinone
    Patent number: 7057047
    Abstract: The present invention relates to methods for making racemic 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone and (+)-2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: June 6, 2006
    Assignee: Indevus Pharmaceuticals, Inc.
    Inventors: Sandra Marie Jennings, Timothy Lee Stuk
  • Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone
    Patent number: 6949653
    Abstract: The present invention relates to methods for making racemic 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone and (+)-2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: September 27, 2005
    Assignee: Indevus Pharmaceuticals, Inc.
    Inventors: Sandra Marie Jennings, Timothy Lee Stuk
  • Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo- tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
    Publication number: 20030195353
    Abstract: An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
    Type: Application
    Filed: January 21, 2003
    Publication date: October 16, 2003
    Inventors: Donald Eugene Butler, Randall Lee Dejong, Jade Douglas Nelson, Michael Gerard Pamment, Timothy Lee Stuk
  • Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone
    Publication number: 20030191315
    Abstract: The present invention relates to methods for making racemic 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone and (+)-2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone.
    Type: Application
    Filed: March 27, 2003
    Publication date: October 9, 2003
    Inventors: Sandra Marie Jennings, Timothy Lee Stuk
  • Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
    Patent number: 6545153
    Abstract: An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: April 8, 2003
    Assignee: Warner-Lambert Company
    Inventors: Donald Eugene Butler, Randall Lee Dejong, Jade Douglas Nelson, Michael Gerard Pamment, Timothy Lee Stuk
  • Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
    Patent number: 6476235
    Abstract: An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: November 5, 2002
    Assignee: Warner-Lambert Company
    Inventors: Donald Eugene Butler, Randall Lee DeJong, Jade Douglas Nelson, Michael Gerard Pamment, Timothy Lee Stuk