Patents by Inventor Timothy M. Blum
Timothy M. Blum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240091449Abstract: An autoinjector and method of injection are described. A power spring causes rotation of a drive nut about the central axis of the autoinjector that, in turn, causes a middle screw to rotate in the same direction as the drive nut and also to move in the distal direction while pushing a center screw in the distal direction that pushes the syringe and needle. The center screw also pushes a plunger that pushes the fluid out of the syringe. After injection, a locked retract screw is freed and rotates in the same direction as the middle screw causing the syringe to retract the syringe into the housing.Type: ApplicationFiled: September 25, 2023Publication date: March 21, 2024Inventors: William G. Atterbury, Timothy M. Blum, David A. Holley, John P. Tallarico, Steven M. Madland
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Patent number: 11801346Abstract: An autoinjector and method of injection are described. A power spring causes rotation of a drive nut about the central axis of the autoinjector that, in turn, causes a middle screw to rotate in the same direction as the drive nut and also to move in the distal direction while pushing a center screw in the distal direction that pushes the syringe and needle. The center screw also pushes a plunger that pushes the fluid out of the syringe. After injection, a locked retract screw is freed and rotates in the same direction as the middle screw causing the syringe to retract the syringe into the housing.Type: GrantFiled: April 9, 2020Date of Patent: October 31, 2023Assignee: Battelle Memorial InstituteInventors: William G. Atterbury, Timothy M. Blum, David A. Holley, John P. Tallarico, Steven M. Madland
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Publication number: 20230277109Abstract: A device for functional electrical stimulation (FES), neuromuscular electrical stimulation (NMES), and/or in receiving electromyography (EMG) signals includes a sleeve and electrodes. The sleeve is sized and shaped to be worn on a human arm, and comprises a stretchable fabric The electrodes are secured with the sleeve and positioned to contact skin of the human arm when the sleeve is worn on the human arm. An electronic circuit is configured to operate the electrodes. The electronic circuit includes relays connecting the electrodes with a stimulator for performing FES or NMES, and EMG readout circuitry connecting the electrodes with an EMG amplifier. The relays are closed during FES or NMES to connect the stimulator with the electrodes. The relays are open during EMG readout to isolate the stimulator from the EMG amplifier.Type: ApplicationFiled: July 30, 2021Publication date: September 7, 2023Inventors: Timothy M. Blum, Joshua R. Branch, Samuel Colachis, Amanda I. Noonan, John E. Bartholomew, Nicholas Annetta, Yelena Davis
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Publication number: 20230208045Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.Type: ApplicationFiled: February 20, 2023Publication date: June 29, 2023Inventors: Eric Scribben, Steven M. Heintz, Amy M. Heintz, Jeffrey L. Ellis, John D. Clay, Timothy M. Blum
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Publication number: 20230191115Abstract: A device for functional electrical stimulation (FES), neuromuscular electrical stimulation (NMES), and/or in receiving electromyography (EMG) signals includes a sleeve and electrodes. The sleeve is sized and shaped to be worn on a human arm, and comprises a stretchable fabric The sleeve has a distal end disposed on or adjacent a wrist of the human arm when the sleeve is worn on the human arm and a proximal end opposite from the distal end. The electrodes are secured with the sleeve and positioned to contact skin of the human arm when the sleeve is worn on the human arm. The sleeve may include an inner sleeve contact with the skin and an outer sleeve disposed over the inner sleeve. The inner sleeve has openings in which the electrodes are disposed.Type: ApplicationFiled: July 14, 2021Publication date: June 22, 2023Inventors: Timothy M. Blum, Joshua R. Branch, Samuel Colachis, Amanda I. Noonan, John E. Bartholomew, Nicholas Annetta, Yelena Davis
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Patent number: 11590285Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.Type: GrantFiled: October 22, 2019Date of Patent: February 28, 2023Assignee: Battelle Memorial InstituteInventors: Eric C. Scribben, Steven M. Risser, Amy M. Heintz, Jeffrey L. Ellis, John D. Clay, Timothy M. Blum
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Publication number: 20200353170Abstract: An autoinjector and method of injection are described. A power spring causes rotation of a drive nut about the central axis of the autoinjector that, in turn, causes a middle screw to rotate in the same direction as the drive nut and also to move in the distal direction while pushing a center screw in the distal direction that pushes the syringe and needle. The center screw also pushes a plunger that pushes the fluid out of the syringe. After injection, a locked retract screw is freed and rotates in the same direction as the middle screw causing the syringe to retract the syringe into the housing.Type: ApplicationFiled: April 9, 2020Publication date: November 12, 2020Inventors: William Atterbury, Timothy M. Blum, David A. Holley, John P. Tallarico, Steven M. Madland
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Publication number: 20200054831Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.Type: ApplicationFiled: October 22, 2019Publication date: February 20, 2020Inventors: Eric C. Scribben, Steven M. Risser, Amy M. Heintz, Jeffrey L. Ellis, John D. Clay, Timothy M. Blum
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Patent number: 10493205Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.Type: GrantFiled: July 17, 2017Date of Patent: December 3, 2019Assignee: Battelle Memorial InstituteInventors: Eric C. Scribben, Steven M. Risser, Amy M. Heintz, Jeffrey L. Ellis, John D. Clay, Timothy M. Blum
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Patent number: 10058657Abstract: Injection devices with ergonomic enhancements are disclosed. Generally, the injection devices include large oversized grips, including flanges at the base end of the device for enhanced stability. Push-type and squeeze-type devices are described, as well as manual injectors and auto-injectors. Such injection devices are useful for delivering a fluid (e.g. medication) to a patient.Type: GrantFiled: November 7, 2012Date of Patent: August 28, 2018Assignee: Eli Lilly and CompanyInventors: Michael Scott Ulrich, Andrew Vankirk Sweeney, Christopher H. Muenzer, Timothy M. Blum, Corrie Bennison, Christopher P. McKenzie
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Patent number: 10046116Abstract: Processes and devices for delivering a fluid by chemical reaction are disclosed. A chemical reaction is initiated in a reaction chamber to produce a gas, and the gas acts upon a piston to deliver the fluid. An exemplary device may include an upper chamber, a lower chamber, a fluid chamber, a piston between the lower chamber and the fluid chamber, and a one-way valve between the upper chamber and the lower chamber.Type: GrantFiled: April 6, 2016Date of Patent: August 14, 2018Assignee: Eli Lilly and CompanyInventors: Corrie Bennison, Christopher H. Muenzer, Timothy M. Blum, Christopher P. McKenzie, Steven M. Madland, Jeffrey L. Ellis, Amy M. Heintz, Brian J. Kaseman
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Patent number: 9861750Abstract: Processes and devices for delivering a fluid by chemical reaction are disclosed. A chemical reaction is initiated in a reaction chamber to produce a gas, and the gas acts upon a piston to deliver the fluid. Preferred devices typically include an upper chamber, a lower chamber, a fluid chamber, a piston between the lower chamber and the fluid chamber, and a barrier between the upper chamber and the lower chamber. When the barrier is broken, reagents in the upper chamber and the lower chamber are mixed together to generate the gas.Type: GrantFiled: April 6, 2016Date of Patent: January 9, 2018Assignee: Eli Lilly and CompanyInventors: Corrie Bennison, Christopher H. Muenzer, Timothy M. Blum, Christopher P. McKenzie, Steven M. Madland, Jeffrey L. Ellis, Amy M. Heintz, Brian J. Kaseman
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Publication number: 20170312434Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.Type: ApplicationFiled: July 17, 2017Publication date: November 2, 2017Inventors: Eric C. Scribben, Steven M. Risser, Amy M. Heintz, Jeffrey L. Ellis, John D. Clay, Timothy M. Blum
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Patent number: 9795740Abstract: Chemical engines and processes for their use and construction are described. The chemical engines can provide powerful and compact devices, especially autoinjectors for the rapid, powered injection of viscous medicines. Novel formulations and designs of chemical engines and delivery technologies employing the chemical engines are described.Type: GrantFiled: October 15, 2013Date of Patent: October 24, 2017Assignee: Eli Lilly and CompanyInventors: Amy M. Heintz, Corrie Bennison, Christopher H. Muenzer, Timothy M. Blum, Christopher P. McKenzie, Steven M. Madland, Jeffrey L. Ellis, Brian Kaseman
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Patent number: 9737662Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.Type: GrantFiled: November 7, 2012Date of Patent: August 22, 2017Assignee: Battelle Memorial InstituteInventors: Eric C. Scribben, John D. Clay, Jeffrey L. Ellis, Amy M. Heintz, Steven M. Risser, Timothy M. Blum
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Publication number: 20160213847Abstract: Processes and devices for delivering a fluid by chemical reaction are disclosed. A chemical reaction is initiated in a reaction chamber to produce a gas, and the gas acts upon a piston to deliver the fluid. Preferred devices typically include an upper chamber, a lower chamber, a fluid chamber, a piston between the lower chamber and the fluid chamber, and a barrier between the upper chamber and the lower chamber. When the barrier is broken, reagents in the upper chamber and the lower chamber are mixed together to generate the gas.Type: ApplicationFiled: April 6, 2016Publication date: July 28, 2016Inventors: Corrie Bennison, Christopher H. Muenzer, Timothy M. Blum, Christopher P. McKenzie, Steven M. Madland, Jeffrey L. Ellis, Amy M. Heintz, Brian J. Kaseman
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Publication number: 20160213846Abstract: Processes and devices for delivering a fluid by chemical reaction are disclosed. A chemical reaction is initiated in a reaction chamber to produce a gas, and the gas acts upon a piston to deliver the fluid. Preferred devices typically include an upper chamber, a lower chamber, a fluid chamber, a piston between the lower chamber and the fluid chamber, and a barrier between the upper chamber and the lower chamber. When the barrier is broken, reagents in the upper chamber and the lower chamber are mixed together to generate the gas.Type: ApplicationFiled: April 6, 2016Publication date: July 28, 2016Inventors: Corrie Bennison, Christopher H. Muenzer, Timothy M. Blum, Christopher P. McKenzie, Steven M. Madland, Jeffrey L. Ellis, Amy M. Heintz, Brian J. Kaseman
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Publication number: 20150313677Abstract: A system for operating a catheter having a distal end adapted to be navigated in the body, and a proximal end having a handle with a translatable control and a rotatable control for acting on the distal end of the device includes a support for receiving and engaging the handle of the catheter; a translation mechanism for advancing and retracting the support to advance and retract a catheter whose handle is received in the support; a rotation mechanism for rotating the support to rotate a catheter whose handle is received in the support; a translation operator for engaging the translatable control of a catheter whose handle is received in the support and operating the translatable control to act on the distal end of the device; and a rotation operator for engaging the rotatable control of a catheter whose handle is received in the support and operating the rotatable control to act on the distal end of the device.Type: ApplicationFiled: April 28, 2015Publication date: November 5, 2015Inventors: Brian L. Kidd, Nathan Kastelein, Gregory A. Trees, Kevin D. Predmore, Gregory S. Kramer, Michael S. Ulrich, James B. Gleeson, Jeffrey R. Held, Timothy M. Blum
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Publication number: 20150314070Abstract: Chemical engines and processes for their use and construction are described. The chemical engines can provide powerful and compact devices, especially autoinjectors for the rapid, powered injection of viscous medicines. Novel formulations and designs of chemical engines and delivery technologies employing the chemical engines are described.Type: ApplicationFiled: October 15, 2013Publication date: November 5, 2015Inventors: Amy M. Heintz, Corrie Bennison, Christopher H. Muenzer, Timothy M. Blum, Christopher P. McKenzie, Steven M. Madland, Jeffrey L. Ellis, Brian Kaseman, Krenar Shqau
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Publication number: 20140324022Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.Type: ApplicationFiled: November 7, 2012Publication date: October 30, 2014Inventors: Eric C. Scribben, Steven M. Risser, Amy M. Heintz, Jeffrey L. Ellis, John D. Clay, Timothy M. Blum