Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A saliva-based testing method that bypasses the need for RNA isolation/purification is described herein. In experiments with inactivated SARS-CoV-2 virus spiked into saliva, this method has a limit of detection of 500-1000 viral particles per mL, rivalling the standard NP swab method. Initial studies showed excellent performance with 100 clinical samples. This saliva-based process is operationally simple, utilizes readily available materials, and can be easily implemented by existing testing sites thus allowing for high-throughput, rapid, and repeat testing of large populations.

Abstract: A method for selecting an alternate wireless communication system for a wireless communication device is disclosed. The method comprises using a first radio access technology (RAT) by a wireless communication device when scanning (202) for an initial wireless communication network (201). The wireless communication device further registers (215) to the initial wireless communication network (201). Then, the initial wireless communication network (201) determines (206) alternate RAT wireless communication network information for the wireless communication device and sends (235) the alternate RAT wireless communication network information to the wireless communication device.

Abstract: Method and apparatus for encoding video is described. In one example, average of motion vectors for each of a plurality of blocks is maintained over a threshold number of inter-coded frames in the video. The running average of motion vectors for each of the plurality of blocks is compared to a threshold value. Each of the plurality of blocks the running average of which does not satisfy the threshold value is encoded using a first quantization parameter. Each of the plurality of blocks the running average of which satisfies the threshold value is encoded using a second quantization parameter. The second quantization parameter results in a coarser quantization of transformed coefficients than the first quantization parameter.

Abstract: A method for selecting an alternate wireless communication system for a wireless communication device is disclosed. The method comprises using a first radio access technology (RAT) by a wireless communication device when scanning (202) for an initial wireless communication network (201). The wireless communication device further registers (215) to the initial wireless communication network (201). Then, the initial wireless communication network (201) determines (206) alternate RAT wireless communication network information for the wireless communication device and sends (235) the alternate RAT wireless communication network information to the wireless communication device.

Abstract: Method and apparatus for encoding video is described. In one example, average of motion vectors for each of a plurality of blocks is maintained over a threshold number of inter-coded frames in the video. The running average of motion vectors for each of the plurality of blocks is compared to a threshold value. Each of the plurality of blocks the running average of which does not satisfy the threshold value is encoded using a first quantization parameter. Each of the plurality of blocks the running average of which satisfies the threshold value is encoded using a second quantization parameter. The second quantization parameter results in a coarser quantization of transformed coefficients than the first quantization parameter.

Abstract: A telephony system 10 having automatic timing adjustment for diverse routing of HFC systems has a signal stream routing through a signal line loop between a head-end 120 and at least one communication unit 16, i.e., a cable modem cable access unit (CAU). If a fault occurs within the signal line loop, recognized by the head-end 120 when a short uplink burst from the communication unit 16 does not align within a predetermined timing window based on a value in the database, the head-end will adjust the cycle through predetermined delay parameters, corresponding to various alternate signal line loops made up of redundant signal lines. An information processor is provided at the head-end 120 of the HFC system 10 for automatically adjusting the timing of the signal stream in order to maintain the database determined at the information processor at the head-end 120. The timing adjustment of the signal stream is communicated between the head-end 120 and the communication units, CAUs 16.

Abstract: An access node that is deployable at a distance from a cable company head-end or a telephone company central office serves residential and business subscribers within a small geographical area. The access node provides interoperability between and across communications links and protocols, thereby providing a modular, configurable access point for both business and residential users that enables the service provider to tailor its services for each user in a cost-effective manner. The access node includes modular interfaces to multiple communications links and protocols on its network side and modular interfaces to multiple communications links and protocols on its user or access side. A switch/router connects the outputs of the two interfaces together and aggregates traffic to the network while simultaneously partitioning traffic to the users to the appropriate connections.

Abstract: An adapter (42) for connecting a telephone (52) to a telephone wire (40) has a subscriber line interface circuit (SLIC 113) with a jack for connecting a telephone to the SLIC, a line interface (110) for coupling to a telephone line, a signaling circuit (111) coupled to the line interface for receiving and providing subscriber line signaling on the telephone line, a codec (112) coupled to the SLIC, performing a voice coding/decoding function; and a timing circuit (202) for time multiplexing and demultiplexing of digitized voice signals between the SLIC and the line interface.

Abstract: A telephony system having automatic timing adjustment for diverse routing of HFC systems has a signal stream routing through a signal line loop between a head-end and at least one communication unit. If a fault occurs within the signal line loop, recognized by the head-end when a short uplink burst from the communication unit does not align within a predetermined timing window, the head-end will cycle through predetermined delay parameters corresponding to various alternate signal line loops made up of redundant signal lines. Once the predetermined delay parameter corresponding to the current alternate signal line loop is determined, normal operation of the system resumes.

Abstract: A system (10) and method for packet telephony power management of a cable distribution network (20), i.e., a hybrid fiber coax (HFC) communication system, for internet protocol (IP) packet telephony information between multiple cable modem subscriber units (16,18) communicated over a public switch telephone network (PSTN) (32) with at least one router (28), e.g., a cable modem termination system (CMTS) on a communication network backbone. Power management is provided to minimize power consumption on the IP telephony distribution system (10) supporting line-powered cable-modem subscriber units (16). The power saving techniques are supported using a virtual broadcast channel (VBC) (62) provided in the packet telephony system using an alert queue (60). The alert queue (60) is established and segmented into a plurality of phases for selective activation, each phase having memory buffers for buffering packet telephony information communicated via the CMTSs (28).

Abstract: A video access apparatus (110, 150, 750, 850) provides for audio and video teleconferencing and telephony via a first communication channel (103) coupled to a primary station (105) having communication with a network (140), such as the public switched telephone network or an ISDN network. The video access apparatus (110) includes a video network interface (210); a radio frequency modulator/demodulator (205); a user interface (215); and a processor arrangement (190). A videophone apparatus (700, 800) is coupleable to a video access apparatus via a second communication channel for video reception and transmission, and via a third communication channel for audio reception and transmission. The videophone apparatus includes a video monitor (715), a camera interface (235), a video camera (720), and a telephony module (710).

Abstract: An apparatus and method are provided for multimedia communications with multiple network functionality, such as conflict resolution for multiple simultaneous communication sessions involving separate and independent networks and call types, such as video and voice.

Abstract: A multimedia interface station (102) establishes a multimedia sensory data link between the Internet (108) and a subscriber premise (112) eliminating an Internet protocol. Visual and audio data received from the Internet (108) is converted to a multimedia sensory signal at the multimedia interface station (102) and transmitted to a sensory transmission device (150) such as a television (142) in the subscriber premise (112) without using the Internet protocol.

Abstract: A method and apparatus in a communications system (100) for providing communications units (134) access to the communications system (100). The communications. system (100) includes a cable distribution network (106) with an base communications unit (102) and a number of downstream communications units (134) all connected to the cable distribution network (106). A plurality of channels are used to transmit data between the base communications unit (102) and the downstream communications units (134). A first set of channels are used primarily for access the communications system (100) and a second set of channels are used for transmitting data within the communications system (100) after access to the communications system (100) has been gained. The base communications unit (102) sends a first type of data transmission including an identification of access channels used for requesting access to the communications system (100).

Abstract: A multimedia control apparatus (101, 201) provides for control over a plurality of media (145), including telephony, video conferencing, video display, home automation and control, and other communication systems such as voice mail. The multimedia control apparatus includes a network interface (110) coupleable to a network communication channel (103) for communication with a network (104); a user interface (120) responsive to receive a first control signal of a plurality of control signals; a plurality of media application modules (140), each media application module of the plurality of media application modules coupleable to a corresponding medium of a plurality of corresponding media (145); and a processor arrangement (130) having a plurality of operating modes.

Abstract: An apparatus (300, 400) and method are provided for multimedia communications, such as for video conferencing. One of the embodiments of the apparatus for multimedia input and control (300) includes a video input (310) to produce an input video signal; an audio input (320) to produce an input audio signal; a radio frequency modulator (350); a data/control input (330) to produce an input data signal; and a processor arrangement (360) responsive when operably coupled, through a set of program instructions, to produce a first processor signal to the radio frequency modulator to combine the input video signal with the input audio signal to form a composite audio/video signal, and the processor arrangement (360) further responsive to modulate the input data signal to form a modulated input data signal and produce a second processor signal to the radio frequency modulator to combine the input video signal with the modulated input data signal to form a combined video/data signal.

Abstract: A method and apparatus in a communication system (100) for allocating and controlling data transmissions to and from communications unit (134) in communications system (100). The communication systems (100) includes a cable distribution network (106) with a base communications unit (102) and a number of downstream communications units (134) all connected to the cable distribution network (106). A plurality of channels are used to transmit data transmissions between the base communications unit (100) and the downstream communications unit (134). Uplink and downlink channels are monitored to determine channel quality for each of the channels in communications system (100). The determined channel quality is used to both initiate transfers of communications links to other frequencies and for assigning channels to various communications units (134).

Abstract: A method and apparatus in a communications system (100) for providing communications units (134) access to the communications system (100). The communications system (100) includes a cable distribution network (106) with a base communications unit (102) and a number of downstream communications units (134) all connected to the cable distribution network (106). A plurality of channels are used to transmit data between the base communications unit (102) and the downstream communications units (134). A first set of channels are used primarily for access to the communications system (100) and a second set of channels are used for transmitting data within the communications system (100) after access to the communications system (100) has been gained. The base communications unit (102) sends a first type of data transmission including an identification of access channels used for requesting access to the communications system (100).

Abstract: A method for synchronizing timing of signal transmissions in a telecommunication system (100) determines a "fixed portion" (222) of the propagation delay between the central unit (102) and subscribers (206, 208) in a particular node (202). Additionally, the method determines a `variable portion` (226) of the propagation delay that accounts for the variation of spacing of different subscribers (e.g., homes (206, 208)) on a particular node (202). The preferred method offsets the control unit's (102) receiving window (410) in accordance with the fixed portion, and directs the various subscriber units (206, 208) to offset the timing of signals (314, 322) (i.e., bursts of data) that they transmit by the variable portion (226).