Abstract: A stent defines a plurality of holes with a therapeutic agent deposited therein and has a plurality of members where at least some of the members overlap when the stent is in the unexpanded state

Abstract: A stent can include a tubular body, a plurality of circumferential serpentine bands, a plurality of connectors extending between immediately adjacent serpentine bands, and a plurality of tabs. The plurality of tabs include peak tabs and trough tabs. Each peak tab and each trough tab have a first end and a second end wherein only the first end is engaged to a serpentine band, each peak tab extends substantially parallel to the longitudinal axis from a peak on a serpentine band toward a peak on an immediately distal serpentine band. Each trough tab extends substantially parallel to the longitudinal axis from a trough on a serpentine band toward a trough on an immediately proximal serpentine band. Each serpentine band defines a plurality of holes and each tab defines a plurality of holes.

Abstract: The present invention is directed to a green fluoropolymer tube which has a wall thickness of about 250 microns or less, preferably about 200 microns or less, and more preferably about 125 microns or less. With such thinness, the green tube may be formed into a tube of expanded fluoropolymer having a wall thickness of about 250 microns or less, preferably about 200 ?m or less and more preferably about 125 microns or less. Such an expanded fluoropolymer tube is particularly well-suited for use as an endovascular prosthesis, such as a graft, or in a stent-graft, because of its flexibility and strength.

Abstract: The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.

Abstract: The present invention provides an apparatus and method for manufacturing polymeric thin-walled tubular members, which are well-suited for use as vascular grafts. The apparatus of the present invention enables extrusion of a tubular member having an extremely thin wall thickness so as to facilitate passage through tortuous vascular passageways. The apparatus achieves uniform wall thickness in a tubular member by establishing and maintaining axial alignment of a ram having a concentrically disposed guide rod therein with a die supported in concentric relation to the guide rod.

Abstract: A stent is provided having attachment members for allowing attachment of a sheath or sheaths. Accordingly, a practitioner is able to selectively choose a desirable sheath, such as a polymeric sleeve, a biomaterial, or a natural blood vessel, at a point-of-use and attach it to the sheath. The attachment members may be bendable tabs and/or secondary support stents.

Abstract: A stent comprises a plurality of axially spaced serpentine bands. Each serpentine band has a proximal and distal end and consists of a plurality of interconnected struts. The struts are of substantially the same length. Serpentine bands which are adjacent one another are connected one to the other. The stent further comprises a plurality of wishbone connectors. Each wishbone connector connects two serpentine bands which are adjacent one another. The wishbone connectors have an elongate portion which is disposed between the two serpentine bands and does not overlap longitudinally with either of the two serpentine bands. The elongate portion has a proximal end and a distal end. The proximal end has two legs extending therefrom to one of the two serpentine bands and the distal end has two legs extending therefrom to the other of the two serpentine bands. At least one wishbone connector connects serpentine bands which are adjacent one another.

Abstract: An endoprothesis comprising a bioerodible body having local erosion rates of the body that vary as a continuous function of radial distance from the longitudinal axis.

Abstract: The present invention provides an apparatus and method for manufacturing polymeric thin-walled tubular members, which are well-suited for use as vascular grafts. The apparatus of the present invention enables extrusion of a tubular member having an extremely thin wall thickness so as to facilitate passage through tortuous vascular passageways. The apparatus achieves uniform wall thickness in a tubular member by establishing and maintaining axial alignment of a ram having a concentrically disposed guide rod therein with a die supported in concentric relation to the guide rod.

Abstract: The invention provides a molded valve leaflet containing a molded biopolymer having fibrils and cells within the molded biopolymer, wherein the fibrils of the molded biopolymer have commisure-to-commisure alignment. The invention also provides a valve equivalent containing a plurality of molded valve leaflets that are connected to a base, wherein the molded valve leaflets include a molded biopolymer having fibrils and cells within the molded biopolymer, wherein the fibrils of the molded biopolymer have commisure-to-commisure alignment.

Abstract: A stent is provided having attachment members for allowing attachment of a sheath or sheaths. Accordingly, a practitioner is able to selectively choose a desirable sheath, such as a polymeric sleeve, a biomaterial, or a natural blood vessel, at a point-of-use and attach it to the sheath. The attachment members may be bendable tabs and/or secondary support stents.

Abstract: A stent comprises a plurality of axially spaced serpentine bands. Each serpentine band has a proximal and distal end and consists of a plurality of interconnected struts. The struts are of substantially the same length. Serpentine bands which are adjacent one another are connected one to the other. The stent further comprises a plurality of wishbone connectors. Each wishbone connector connects two serpentine bands which are adjacent one another. The wishbone connectors have an elongate portion which is disposed between the two serpentine bands and does not overlap longitudinally with either of the two serpentine bands. The elongate portion has a proximal end and a distal end. The proximal end has two legs extending therefrom to one of the two serpentine bands and the distal end has two legs extending therefrom to the other of the two serpentine bands. At least one wishbone connector connects serpentine bands which are adjacent one another.

Abstract: The present invention provides an apparatus and method for manufacturing polymeric thin-walled tubular members, which are well-suited for use as vascular grafts. The apparatus of the present invention enables extrusion of a tubular member having an extremely thin wall thickness so as to facilitate passage through tortuous vascular passageways. The apparatus achieves uniform wall thickness in a tubular member by establishing and maintaining axial alignment of a ram having a concentrically disposed guide rod therein with a die supported in concentric relation to the guide rod.

Abstract: The present invention is directed to a green fluoropolymer tube which has a wall thickness of about 250 microns or less, preferably about 200 microns or less, and more preferably about 125 microns or less. With such thinness, the green tube may be formed into a tube of expanded fluoropolymer having a wall thickness of about 250 microns or less, preferably about 200 &mgr;m or less and more preferably about 125 microns or less. Such an expanded fluoropolymer tube is particularly well-suited for use as an endovascular prosthesis, such as a graft, or in a stent-graft, because of its flexibility and strength.

Abstract: A platinum enhanced radiopaque alloy particularly suitable for manufacture of implantable and/or intravascular medical devices. A stent is one preferred medical device which is a generally tubular structure that is expandable upon implantation in a vessel lumen to maintain flow therethrough. The stent is formed from the alloy which has improved radiopacity relative to present utilized stainless steel alloys. This alloy preferably contains from about 2 wt. % to about 50 wt. % platinum; from about 11 wt. % to about 18 wt. % chromium; about 5 wt. % to about 12 wt. % nickel and at least about 15 wt. % iron.

Abstract: A stent comprises a plurality of circumferential bands. Circumferential bands which are adjacent one another are connected one to the other. The circumferential bands include first circumferential bands characterized by a first number of alternating first peaks and first troughs joined by bent struts and second circumferential bands characterized by a second number of alternating second peaks and second troughs joined by bent struts, the second number different from the first number.

Abstract: A stent comprises a plurality of circumferential bands. Circumferential bands which are adjacent one another are connected one to the other. The circumferential bands include peaks and troughs interconnected by bent struts. The bands may overlap or may be connected by connectors.