Abstract: A nozzle for a fluid delivery device includes a nozzle head. The nozzle head defines an inner head chamber for a fluid. The nozzle head has at least one nozzle opening through which fluid is configured to be selectively delivered from the head chamber to a target site during use of the device. The nozzle head is at least partially formed from a deformable material. The nozzle head is selectively deflectable between an opened condition in which the at least one nozzle opening is at least partially open to permit fluid flow therethrough and a closed condition in which the at least one nozzle opening is at least partially closed to restrict fluid flow therethrough.

Abstract: A nozzle for a fluid delivery device includes a nozzle wall having opposing interior and exterior nozzle surfaces, and at least one opening through which fluid is configured to be selectively delivered to a target site of a user during use of the fluid delivery device. The at least one opening is defined by an inner opening surface and extends through the nozzle wall from the interior nozzle surface to the exterior nozzle surface. The exterior nozzle surface is configured to be directed toward the eye of the user during use of the fluid delivery device. The exterior nozzle surface is configured to be at least hydrophobic. At least a portion of the inner opening surface is configured to be hydrophilic.

Abstract: A cartridge storing a therapeutic agent can be authenticated before the therapeutic agent is applied to a user using an inexpensive process involving cloud storage and color detection. An applicator for delivering the therapeutic agent can include a space for receiving a cartridge that can be selected from a group of cartridges, a color sensor configured to detect the color of a color-coded identifying mark on the selected cartridge, and a processor that can receive profile information from a cloud service, including color information of what the color-code identifying mark should be, and match the color of the color-coded identifying mark on the cartridge with the color information. The processor can control if the applicator allows delivery of the therapeutic agent based on the authentication. The profile information can be uploaded by scanning a QR code on the cartridge and uploading associated data to the cloud service.

Abstract: A non-gravitational fluid delivery device is provided for delivering fluid to an eye of a user. The device includes a nozzle having a nozzle wall. The nozzle wall has opposing interior and exterior nozzle surfaces, and a plurality of openings dispersed along a longitudinal nozzle width of the nozzle wall through which fluid is configured to be selectively delivered to the eye during use of the device. Each opening extends through the nozzle wall from a substantially rectangular entry port in the interior nozzle surface to a substantially rectangular port in the exterior nozzle surface. Each of the openings has a longitudinal opening width that is less than a lateral opening length.

Abstract: Systems and methods are provided for applying a drop of a therapeutic to an eye of a user. Reflected light from the eye of the user is measured at a sensor to provide a time series of intensity values. It is determined from the time series of intensity values if the eye has blinked. The drop of the therapeutic is released in response to a determination that the eye has blinked.

Abstract: A blister package for ophthalmic drugs that includes a base layer having a first side and a second side. At least one dome extends from the first side with each dome defining a cavity that receives a liquid drug dose. An intermediate layer extends over the second side of the base layer and covers each cavity. The intermediate layer includes an integrally formed nozzle aligned with each cavity. A removable layer extends over the intermediate layer and is releasable from the intermediate layer for uncovering each nozzle opening.

Abstract: An eye sprayer includes a spray nozzle having a nozzle axis. the spray nozzle is configured to produce eye spray. The eye sprayer also includes a concave mirror with an opening configured to allow for the delivery eye spray from the spray nozzle. The eye sprayer further includes a light emitter configured to produce a visible light beam directed from the mirror along the nozzle axis.

Abstract: An ophthalmic applicator for treating an eye of a user includes a housing and a reservoir, supported by the housing, for containing a liquid for treating the eye. The applicator also includes a nozzle supported by the housing and operatively connected to the reservoir. The nozzle is configured a non-gravitationally directed dose of the liquid. The applicator further includes a proximity sensor configured to identify the eye, left or right, to which the applicator is applying the liquid to the eye of the user.

Abstract: Aspects of the present disclosure include fluid dispensers configured to administer pharmaceutical agents to a user's eye. The fluid dispensers and systems described herein include mechanisms for protecting a fluid dispensing nozzle or opening from contamination, preventing dehydration of the fluids, and for sterilizing the dispensing components. A fluid dispenser may include a housing configured to receive a fluid cartridge, the fluid cartridge comprising a nozzle. The housing further comprises a shutter coupled to the housing and configured to articulate between a closed position and an open position. The shutter may be configured to obscure the nozzle in the closed position and to expose the nozzle in the open position. The shutter may further include protrusion configured to engage and actuate a nozzle cover of the fluid cartridge when the shutter articulates to the open position.

Abstract: An apparatus massages an eyelid to move meibum unidirectionally through a meibomian gland duct toward a gland duct orifice at the eyelid margin in order to clear meibum blockage in the gland duct. The apparatus is configured to cyclically apply pressure to an application area of the eyelid, to move the applied pressure in a flow direction toward the gland duct orifice, and release the pressure applied to the application area of the eyelid. The apparatus includes an elongated massage arm configured to support a massage tip, which is configured to apply the pressure to the application area of the eyelid. A cam is rotatable about an axis of rotation and includes a cam surface. A follower includes a follower surface in sliding engagement with the cam surface. The follower is configured to impart massaging motion to the massage arm in response to rotation of the cam. The cam surface has a constant width curve configuration.

Abstract: Systems, devices and methods that facilitate safe heating of eyelids to treat dry eye are disclosed. According to one embodiment, an apparatus for optical heating of an eyelid of a patient includes: a housing configured to be grasped by a human hand; at least one light emitter coupled to the housing and configured to emit beams of infrared light; a waveguide component coupled to the at least one light emitter and configured to direct the beams of light toward the eyelid; and a scleral cover configured to couple to the housing, the scleral cover comprising: a curved protective portion configured to reflect infrared light emanating from the at least one light emitter.

Abstract: A sensor cable support device is described. The sensor cable support device can be used to implemented in wearable monitoring device to support a proximal portion of a sensor cable and electrically connect the proximal portion with a sensing circuitry. A distal portion of the sensor cable is insertable into a person's skin. The sensor cable support device may include a rigid body defining a pair of openings, a set legs attached to the rigid body, and a pair of electrical traces extending between the pair of openings and distal ends of a pair of legs of the set of legs. The pair of openings may be sized and configured to receive a pair of pucks that mechanically retain a sensor cable to the body and electrically connect the sensor cable with the electrical traces.

Abstract: A device is presented herein that is configured to be located underneath an eyelid and worn by a user for treating dry eye. The device includes a first surface configured to face a portion of a sclera of the eye, and a second surface configured to face an eyelid and to be completely covered by the eyelid. In some embodiments, the device further includes a plurality of stimulation electrodes proximal to the first surface, wherein the plurality of stimulation electrodes is configured to stimulate the sclera. The device further includes an energy storage element coupled to the plurality of stimulation electrodes. The energy storage element is configured to supply power to the plurality of stimulation electrodes. The device further includes a processor configured to control a supply of energy from the energy storage element to the plurality of stimulation electrodes to stimulate the sclera.

Abstract: A sensor cable support device is described. The sensor cable support device can be used to implemented in wearable monitoring device to support a proximal portion of a sensor cable and electrically connect the proximal portion with a sensing circuitry. A distal portion of the sensor cable is insertable into a person's skin. The sensor cable support device may include a rigid body defining a pair of openings, a set legs attached to the rigid body, and a pair of electrical traces extending between the pair of openings and distal ends of a pair of legs of the set of legs. The pair of openings may be sized and configured to receive a pair of pucks that mechanically retain a sensor cable to the body and electrically connect the sensor cable with the electrical traces.

Abstract: A fluid dispensing device includes a cartridge comprising a housing and a head coupled to the housing. The housing forms a first chamber configured to accommodate a fluid; and the head includes a nozzle; and an elastomeric wall that is spaced from the nozzle to form a holding chamber. The holding chamber is in fluid communication with the first chamber and configured to accommodate a portion of the fluid; and the nozzle forms one or more openings to eject the portion of the fluid from the holding chamber. The one or more openings form an oblong shape such that a length of the oblong shape is greater than a width of the oblong shape. The one or more openings can include two parallel slots that together form the oblong shape.

Abstract: In some aspects, an apparatus for a biosensor includes a sensor wire and a rigid member. The rigid member may be coupled to the sensor wire and include a contact surface. The contact surface may be sized to enable a suction head of a robotic placement device to create a vacuum seal on the contact surface for lifting the sensor wire and rigid member.

Abstract: A fluid dispensing device includes a light source, and a nozzle spaced from the light source. The device also includes a membrane positioned within a beam path of the light source, where the membrane is configured to allow a portion of light from the light source through to the nozzle. The device also includes a fluid chamber positioned between the membrane and the nozzle, where the nozzle is configured to allow a beam of the portion of light to pass through along the beam path, and where the nozzle is further configured to form a stream of fluid expelled from the fluid chamber along the beam path.

Abstract: In some aspects, an apparatus for a biosensor includes a sensor wire and a rigid member. The rigid member may be coupled to the sensor wire and include a contact surface. The contact surface may be sized to enable a suction head of a robotic placement device to create a vacuum seal on the contact surface for lifting the sensor wire and rigid member.

Abstract: A fluid dispensing device includes a cartridge comprising a housing and a head coupled to the housing. The housing forms a first chamber configured to accommodate a fluid; and the head includes a nozzle; and an elastomeric wall that is spaced from the nozzle to form a holding chamber. The holding chamber is in fluid communication with the first chamber and configured to accommodate a portion of the fluid; and the nozzle forms one or more openings to eject the portion of the fluid from the holding chamber. The one or more openings form an oblong shape such that a length of the oblong shape is greater than a width of the oblong shape. The one or more openings can include two parallel slots that together form the oblong shape.

Abstract: According to some aspects, a device is presented herein that is configured to be located underneath an eyelid and worn by a user for treating dry eye. The device includes a first surface configured to face a portion of a sclera of the eye, and a second surface configured to face an eyelid and to be completely covered by the eyelid. In some embodiments, the device further includes a plurality of stimulation electrodes proximal to the first surface, wherein the plurality of stimulation electrodes is configured to stimulate the sclera. The device further includes an energy storage element coupled to the plurality of stimulation electrodes. The energy storage element is configured to supply power to the plurality of stimulation electrodes. The device further includes a processor configured to control a supply of energy from the energy storage element to the plurality of stimulation electrodes to stimulate the sclera.