Abstract: A laminate includes a first glass article having a first thickness, a first annealing point (TA1), and a first softening point (TS1), a second glass article having a second thickness, a second annealing point (TA2), and a second softening point (TS2), and an interlayer disposed between the first glass article and the second glass article. The first thickness is greater than the second thickness, the second annealing point (TA2) is less than or equal to the first annealing point (TA1), and the second softening point (TS2) is greater than the first softening point (TS1).

Abstract: A multimode system for receiving data in a retail environment includes: a secure input module for receiving high security input and low security input from a customer, the high security input to be communicated by the secure input module in cipher text, and the low security input to be communicated by the secure input module in plaintext. The multimode system is adapted to operate in a high security mode and a low security mode. The multimode system is adapted to enter the low security mode upon detection by the multimode system of a security breach condition. In the high security mode, the secure input module accepts low security input and high security input. In the low security mode, the secure input module accepts the low security input and does not accept the high security input.

Abstract: This disclosure provides various embodiments of systems and methods for secure communications. In one aspect, the system includes a secure payment module (SPM) in a fuel dispenser and a point-of-sate (POS) system. The POS system stores a public key certificate uniquely identifying the SPM and is configured to dynamically generate a first session key. The POS system encrypts the first session key with a public key associated with the public key certificate, and transmits the encrypted first session key to the SPM. The SPM, which stores a private key associated with the public key certificate, is configured to receive and decrypt the first session key. The SPM is further configured to receive a set of magnetic card data from a card reader, encrypt the set of magnetic card data with the first session key, and transmit the encrypted set of magnetic card data to the POS system.

Abstract: The present application relates to oligonucleotides (e.g., antisense oligonucleotides such as gapmers) designed to target DMPK RNAs and targeting complexes for delivering the oligonucleotides to cells (e.g., muscle cells) and uses thereof, particularly uses relating to treatment of disease. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of DMPK.

Abstract: A fluid management system includes a pump configured to pump fluid through the system at a fluid flow rate. The system includes a processor including a user interface, the user interface allowing a user to input a set of system operating parameters, the processor being configured to control the pump to maintain a target fluid flow rate based on the set of system operating parameters. The system further includes a scope device coupled to the pump to deliver fluid to a target surgical site, the scope device including an elongated shaft extending from a distal end thereof, the elongated shaft including at least one sensor, the sensor transmitting sensor data relating to target surgical site to the processor. The processor automatically signals to the pump to adjust the fluid flow rate based on the sensor data.

Abstract: Aspects of the disclosure relate to complexes and other aspects relate to formulations (e.g., aqueous, lyophilized forms) comprising such complexes comprising an oligonucleotide (e.g., useful for targeting DMPK) covalently linked to an antibody (e.g., anti-TfR1 antibody).

Abstract: An approach for providing intelligent caching is disclosed. A communications system includes a first caching logic that is configured to analyze a traffic stream for content and to output a first profile of the content. The system also includes a second caching logic that is configured to generate a second profile based upon the first profile, wherein the second profile is used to retrieve content. The content associated with the second profile may be pre-loaded into remote cache using multicasting over a wide area network (WAN), such as, a satellite network.